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Gene regulation through RNA interference can be described by which of the following statement?
- a)Small RNA molecules cleave dsDNA of specific genes
- b)RISC - bound siRNAs bind to complementary mRNAs
- c)RISC enzyme cleaves double stranded mRNAs
- d)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate it
Correct answer is option 'B'. Can you explain this answer?
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Gene regulation through RNA interference can be described by which of ...
Small interfering RNAs are a class of double stranded RNA molecules, which play important roles in gene silencing through RNA interference pathway. Structurally, they are formed after long dsRNA is cleaved by enzyme Dicer. Once siRNA enters inside the cell through transfection, it is incorporated into other proteins to form RISC (RNA induced silencing complex). Inside the RISC, siRNA is unwound to form ssRNA. The ssRNA, which is a part of RISC scans and finds a complementary mRNA and induces its cleavage and thus silences the corresponding gene.
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Gene regulation through RNA interference can be described by which of ...
RNA Interference Process
RNA interference (RNAi) is a process in which small RNA molecules inhibit gene expression by targeting specific mRNA molecules. This regulation process is carried out by the RNA-induced silencing complex (RISC).
RISC Binding to siRNAs
- In RNA interference, RISC is bound to small interfering RNAs (siRNAs) which are typically 20-25 nucleotides long.
- These siRNAs are double-stranded RNA molecules that are processed and loaded onto RISC.
Complementary Binding to mRNA
- The RISC-bound siRNAs then guide the complex to complementary sequences on target mRNA molecules.
- This binding of siRNAs to the mRNA leads to the cleavage of the mRNA by the RISC enzyme.
RISC Cleavage of mRNA
- The RISC enzyme cleaves the target mRNA at specific sites, leading to the degradation of the mRNA molecule.
- As a result, the targeted gene's expression is silenced, as the mRNA molecule cannot be translated into protein.
Gene Silencing
- Silencing by RNA interference involves the specific binding of small RNAs to target genes, leading to the inactivation of these genes.
- This process allows for precise regulation of gene expression and can be utilized for various research and therapeutic applications.
RNA interference (RNAi) is a process in which small RNA molecules inhibit gene expression by targeting specific mRNA molecules. This regulation process is carried out by the RNA-induced silencing complex (RISC).
RISC Binding to siRNAs
- In RNA interference, RISC is bound to small interfering RNAs (siRNAs) which are typically 20-25 nucleotides long.
- These siRNAs are double-stranded RNA molecules that are processed and loaded onto RISC.
Complementary Binding to mRNA
- The RISC-bound siRNAs then guide the complex to complementary sequences on target mRNA molecules.
- This binding of siRNAs to the mRNA leads to the cleavage of the mRNA by the RISC enzyme.
RISC Cleavage of mRNA
- The RISC enzyme cleaves the target mRNA at specific sites, leading to the degradation of the mRNA molecule.
- As a result, the targeted gene's expression is silenced, as the mRNA molecule cannot be translated into protein.
Gene Silencing
- Silencing by RNA interference involves the specific binding of small RNAs to target genes, leading to the inactivation of these genes.
- This process allows for precise regulation of gene expression and can be utilized for various research and therapeutic applications.
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Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer?
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Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer?.
Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer?.
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Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer?, a detailed solution for Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer? has been provided alongside types of Gene regulation through RNA interference can be described by which of the following statement?a)Small RNA molecules cleave dsDNA of specific genesb)RISC - bound siRNAs bind to complementary mRNAsc)RISC enzyme cleaves double stranded mRNAsd)Silencing by RNA interference involves binding of a small RNA to target gene to inactivate itCorrect answer is option 'B'. Can you explain this answer? theory, EduRev gives you an
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