Asymmetric Catalysis Notes | EduRev

Created by: Mohit Garg

: Asymmetric Catalysis Notes | EduRev

 Page 1


        Asymmetric Catalysis 
(R)-2-butanol (S)-2-butanol 
Page 2


        Asymmetric Catalysis 
(R)-2-butanol (S)-2-butanol 
Outline 
•? Need for making chiral molecules 
•? Possible routes to chiral molecules 
•? Asymmetric Catalysis & Organometallic 
chemistry (chirality at metal and ligand) 
•? Chiral Ligand Design 
•? Main group AC  
 
Page 3


        Asymmetric Catalysis 
(R)-2-butanol (S)-2-butanol 
Outline 
•? Need for making chiral molecules 
•? Possible routes to chiral molecules 
•? Asymmetric Catalysis & Organometallic 
chemistry (chirality at metal and ligand) 
•? Chiral Ligand Design 
•? Main group AC  
 
•? Need for making chiral molecules 
•? Possible routes to chiral molecules 
•? Asymmetric Catalysis & Organometallic 
chemistry (chirality at metal and ligand) 
•? Chiral Ligand Design  
•? Main group AC 
Page 4


        Asymmetric Catalysis 
(R)-2-butanol (S)-2-butanol 
Outline 
•? Need for making chiral molecules 
•? Possible routes to chiral molecules 
•? Asymmetric Catalysis & Organometallic 
chemistry (chirality at metal and ligand) 
•? Chiral Ligand Design 
•? Main group AC  
 
•? Need for making chiral molecules 
•? Possible routes to chiral molecules 
•? Asymmetric Catalysis & Organometallic 
chemistry (chirality at metal and ligand) 
•? Chiral Ligand Design  
•? Main group AC 
(+)$(S)$2$(6$methoxynaphthalen$2$yl)2
propanoic2acid2
($)$(R)$2$(6$methoxynaphthalen$2$yl)2
propanoic2acid2
Drug2for2arthri;s2 Liver2poisoning2
Biological activity of molecules containing asymmetric centres 
depend on the chirality of the molecule! 
Naproxen)
h?p://en.wikipedia.org/wiki/Naproxen2
4 
Page 5


        Asymmetric Catalysis 
(R)-2-butanol (S)-2-butanol 
Outline 
•? Need for making chiral molecules 
•? Possible routes to chiral molecules 
•? Asymmetric Catalysis & Organometallic 
chemistry (chirality at metal and ligand) 
•? Chiral Ligand Design 
•? Main group AC  
 
•? Need for making chiral molecules 
•? Possible routes to chiral molecules 
•? Asymmetric Catalysis & Organometallic 
chemistry (chirality at metal and ligand) 
•? Chiral Ligand Design  
•? Main group AC 
(+)$(S)$2$(6$methoxynaphthalen$2$yl)2
propanoic2acid2
($)$(R)$2$(6$methoxynaphthalen$2$yl)2
propanoic2acid2
Drug2for2arthri;s2 Liver2poisoning2
Biological activity of molecules containing asymmetric centres 
depend on the chirality of the molecule! 
Naproxen)
h?p://en.wikipedia.org/wiki/Naproxen2
4 
Need for enantiopure drugs 
The anti-arthritic activity of penicillamine resides with the (S)-enantiomer 
while the (R)-form is extremely toxic  
 
(R)-Thalidomide is a sedative and hypnotic whereas the (s)-Thalidomide is 
a teratogenic! 
 
The (S,S)-form of ethambutol is a tuberculostatic agent but the (R,R)-form 
causes optical neuritis and can lead to blindness  
 
Levo-dopa (L-dopa) used for Parkinson's disease  is marketed in an 
enantiomerically pure form because the D-form causes loss of white blood 
cells . 
 
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