Computer Science Engineering (CSE)  >  Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Document Description: Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering for Computer Science Engineering (CSE) 2022 is part of Computer Science Engineering (CSE) preparation. The notes and questions for Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering have been prepared according to the Computer Science Engineering (CSE) exam syllabus. Information about Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering covers topics like and Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Example, for Computer Science Engineering (CSE) 2022 Exam. Find important definitions, questions, notes, meanings, examples, exercises and tests below for Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering.

Introduction of Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering in English is available as part of our Computer Science Engineering (CSE) preparation & Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering in Hindi for Computer Science Engineering (CSE) courses. Download more important topics, notes, lectures and mock test series for Computer Science Engineering (CSE) Exam by signing up for free. Computer Science Engineering (CSE): Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)
1 Crore+ students have signed up on EduRev. Have you?

Biosystems Control Design

 

Chapter 23 addresses a variety of synthesis  problems in the field of biosystems:

  • Pharmaceutical Operations

    • Bioreactors

    • Crystallizers

    • Granulation

  • Drug Delivery

    • Type 1 Diabetes

    • Blood Pressure Control

    • Cancer Treatment

    • Controlled Treatment for HIV/AIDS

    • Cardiac Assist Devices

Advanced Process Control ------------------------------------------Next Slide

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.1 Schematic of a typical industrial fermentor.

 

Advanced Process Control ------------------------------------------Next Slide

 

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.2 Step response of fermentor model to symmetric changes in dilution of magnitude 10% from the nominal value of D=0.202 h-1.

 

Advanced Process Control ------------------------------------------Next Slide

 

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.3 Step response of fermentor model to symmetric changes in dilution of magnitude 10% from the  nominal value of D=0.0389 h-1.

 

Advanced Process Control ------------------------------------------Next Slide

 

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.4 Flowsheet of a typical industrial crystallizer showing concentration and temperature controllers, including cascade control for temperature.

 

Advanced Process Control ------------------------------------------Next Slide

 

Hierarchy of Process Information

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Need relationships between levels to deliver product which consistently meets the customers needs

Advanced Process Control ------------------------------------------Next Slide

 

Specific Challenges in Agglomeration Control

Various process operations

 

  • granulation
  • polymerization

  • spray drying

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Common characteristics

  • real-time analysis required for distribution
  • complex heat/mass/momentum transfer problems

  • multiple attributes of interest (size, shape, concentration, etc.)

  • high dimension, stiff models

  • underactuated

 

Advanced Process Control ------------------------------------------Next Slide

 

Granulation Control – Challenges

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Multivariable interactions (5th and 90th percentiles)

No target (setpoint) for 5th and 90th percentiles

  • One-sided limits

Data acquisition is difficult.Suggested Operating Objectives:

  • Track bulk density to reference
  • Minimize control effort if PSD within limits

  • Strong action if PSD out of limits

 

Advanced Process Control ------------------------------------------Next Slide

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.5 Process flowsheet for granulation circuit with recycle.

 

Advanced Process Control ------------------------------------------Next Slide

 

Case Study
[Pottman, Ogunnaike, Adetayo, and Ennis, Powder Tech., 1999]

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE) Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

 

Correlated Process Variables

  • particle size distribution (5th, 90th percentiles)
  • bulk density

Manipulated Variables

  • 3 spray nozzles (flow rate) [bounded]

Advanced Process Control ------------------------------------------Next Slide

 

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.6 Simplified process flowsheet for granulator example. Here u1, u2, u3 are, respectively, nozzles 1,2, and 3, and y1, y2, y3 are, respectively, bulk density, d5 and d90.

 

Advanced Process Control ------------------------------------------Next Slide

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.7 Closed-loop response of granulator to +10 step change in set point for y1 – left plot is outputs, right plot is inputs (dashed line, y1 and u1; dotted line, y2 and u2; dash-dot line, y3 and u3).

Advanced Process Control ------------------------------------------Next Slide

 

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.8 Closed-loop response of granulator to +50 step change in set point for y1 with constraints enforced on the inputs. The left plot is outputs, right plot is inputs (dashed line, y1 and u1; dotted line, y2 and u2; dash-dot line, y3 and u3).

 

Advanced Process Control ------------------------------------------Next Slide

 

Diabetes Mellitus

World’s most common and costly disease

About one in every 400 to 600 children and adolescents has type 1 diabetes mellitus (T1DM)

National Diabetes Fact Sheet, 2005, Centers for Disease Control and Prevention

Complications of T1DM reduce life expectancy by ~15 years through micro- and macro-vascular disease

 

  • Heart disease and stroke
  • Blindness

  • Kidney disease

  • Nervous system disease

Evidence that intensive insulin therapy (IIT) reduces complications

  • Diabetes Control and Complications Trial Research Group, 1993

Increased hypoglycemic events with IIT

Diabetes Control and Complications Trial Research Group, 1993

 

Advanced Process Control ------------------------------------------Next Slide

 

Model-Based Control Approach for Diabetes
[Parker, Peppas, Doyle III, IEEE Trans Biomed. Eng. 1999]

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

 

Advanced Process Control ------------------------------------------Next Slide

 

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.9 Block diagram for artificial β-cell, illustrating the meal as the most common disturbance. G denotes the blood sugar of the patient, Gm is the output of the glucose sensor, and Gsp is the glucose setpoint.

Advanced Process Control ------------------------------------------Next Slide

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.10 Open-loop response of patient’s blood glucose when the insulin pump is turned off.

 

Advanced Process Control ------------------------------------------Next Slide

 

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.11 Open-loop response of the patient’s blood glucose to a constant infusion rate of 15 mU/min  from her insulin pump.

 

Advanced Process Control ------------------------------------------Next Slide

 

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)

Figure 23.12 Open-loop response of patient’s blood glucose to a constant infusion rate of 25 mU/min  from her insulin pump.

Advanced Process Control ------------------------------------------Next Slide

 

Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE)
Figure 23.13 Closed-loop response of patient’s mean arterial blood pressure and cardiac output to a -10 mmHg change in the MAP set point.

The document Chapter23 - Biosystems Control Design, PPT, Chemical Engineering, Semester, Engineering Notes - Computer Science Engineering (CSE) is a part of Computer Science Engineering (CSE) category.
All you need of Computer Science Engineering (CSE) at this link: Computer Science Engineering (CSE)
Download as PDF

Download free EduRev App

Track your progress, build streaks, highlight & save important lessons and more!

Related Searches

Semester Notes

,

Semester

,

Chemical Engineering

,

pdf

,

MCQs

,

Semester

,

mock tests for examination

,

Viva Questions

,

PPT

,

video lectures

,

Semester

,

Engineering Notes - Computer Science Engineering (CSE)

,

Engineering Notes - Computer Science Engineering (CSE)

,

Chemical Engineering

,

Important questions

,

Free

,

Summary

,

shortcuts and tricks

,

Chapter23 - Biosystems Control Design

,

Chapter23 - Biosystems Control Design

,

Chemical Engineering

,

Previous Year Questions with Solutions

,

Chapter23 - Biosystems Control Design

,

PPT

,

Objective type Questions

,

study material

,

Exam

,

Sample Paper

,

past year papers

,

PPT

,

Engineering Notes - Computer Science Engineering (CSE)

,

ppt

,

Extra Questions

,

practice quizzes

;