Gluconeogenesis + Evaluations Notes | EduRev

: Gluconeogenesis + Evaluations Notes | EduRev

 Page 1


Gluconeogenesis 
+ 
Evaluations 
 
4/23/2003 
Page 2


Gluconeogenesis 
+ 
Evaluations 
 
4/23/2003 
Overview of Glucose Metabolism 
Page 3


Gluconeogenesis 
+ 
Evaluations 
 
4/23/2003 
Overview of Glucose Metabolism 
Gluconeogenesis 
Gluconeogenesis is the process whereby precursors 
such as lactate, pyruvate, glycerol, and amino acids 
are converted to glucose. 
Fasting requires all the glucose to be synthesized 
from these non-carbohydrate precursors. 
Most precursors must enter the Krebs cycle at some 
point to be converted to oxaloacetate.   
Oxaloacetate is the starting material for 
gluconeogenesis 
Page 4


Gluconeogenesis 
+ 
Evaluations 
 
4/23/2003 
Overview of Glucose Metabolism 
Gluconeogenesis 
Gluconeogenesis is the process whereby precursors 
such as lactate, pyruvate, glycerol, and amino acids 
are converted to glucose. 
Fasting requires all the glucose to be synthesized 
from these non-carbohydrate precursors. 
Most precursors must enter the Krebs cycle at some 
point to be converted to oxaloacetate.   
Oxaloacetate is the starting material for 
gluconeogenesis 
Page 5


Gluconeogenesis 
+ 
Evaluations 
 
4/23/2003 
Overview of Glucose Metabolism 
Gluconeogenesis 
Gluconeogenesis is the process whereby precursors 
such as lactate, pyruvate, glycerol, and amino acids 
are converted to glucose. 
Fasting requires all the glucose to be synthesized 
from these non-carbohydrate precursors. 
Most precursors must enter the Krebs cycle at some 
point to be converted to oxaloacetate.   
Oxaloacetate is the starting material for 
gluconeogenesis 
Pyruvate is converted to oxaloacetate before 
being changed to Phosphoenolpyruvate 
1. Pyruvate carboxylase catalyses the ATP-driven 
formation of oxaloacetate from pyruvate and CO
2
 
2. PEP carboxykinase (PEPCK) concerts oxaloacetate 
to PEP that uses GTP as a phosphorylating agent. 
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