Life Sciences - XL 2018 GATE Paper with solution - Set - 4 GATE Notes | EduRev

GATE Past Year Papers for Practice (All Branches)

GATE : Life Sciences - XL 2018 GATE Paper with solution - Set - 4 GATE Notes | EduRev

 Page 1


GATE 2018    Microbiology (XL-S) 
XL-S 1/3 
XL (S): Q. 1 – Q. 10 carry one mark each & Q. 11 – Q. 20 carry two marks each. 
Q.1  David Baltimore’s classification of viruses is based on differences in  
 (A) host cell receptors used by viruses  
(B) the pathways required to synthesize virus mRNA 
(C) the modes of transmission of viruses 
(D) the envelope proteins on the surface of viruses 
 
 
Q.2  Which of the following immune system components can function as an opsonin? 
(A) Antibodies (B) T-cell receptors 
(C) Histamines (D) Interferons 
 
 
Q.3  The oral polio vaccine (OPV) consists of 
(A) live attenuated virus (B) killed virus 
(C) viral toxin (D) viral capsid subunit 
 
 
Q.4  Which of the following eukaryotic cellular components carries out intracellular degradation 
during autophagy? 
(A) Nucleus (B) Golgi bodies (C) Ribosomes (D) Lysosomes 
 
 
Q.5  Analysis of DNA sequences suggest that eukaryotic mitochondrial genomes primarily 
originated from   
(A) fungi  (B) protozoa  (C) algae  (D) bacteria 
 
 
Q.6  Binomial nomenclature has NOT yet been adopted for 
(A) bacteria (B) fungi (C) viruses (D) protozoa 
 
 
Q.7  Which of the following is NOT an accepted method for sterilization? 
(A) Autoclaving (B) X-rays 
(C) Gamma rays (D) UV rays 
 
 
Q.8  The primary product of nitrogen fixation is  
(A) N2 (B) NH4
+
 (C) NO2
?
 (D) NO3 
 
 
Q.9  In humans, the key stages in the life cycle of malarial parasites occur in 
(A) red blood cells and the liver 
(B) red blood cells and platelets 
(C) red blood cells and the pancreas 
(D) red blood cells and the gut 
Page 2


GATE 2018    Microbiology (XL-S) 
XL-S 1/3 
XL (S): Q. 1 – Q. 10 carry one mark each & Q. 11 – Q. 20 carry two marks each. 
Q.1  David Baltimore’s classification of viruses is based on differences in  
 (A) host cell receptors used by viruses  
(B) the pathways required to synthesize virus mRNA 
(C) the modes of transmission of viruses 
(D) the envelope proteins on the surface of viruses 
 
 
Q.2  Which of the following immune system components can function as an opsonin? 
(A) Antibodies (B) T-cell receptors 
(C) Histamines (D) Interferons 
 
 
Q.3  The oral polio vaccine (OPV) consists of 
(A) live attenuated virus (B) killed virus 
(C) viral toxin (D) viral capsid subunit 
 
 
Q.4  Which of the following eukaryotic cellular components carries out intracellular degradation 
during autophagy? 
(A) Nucleus (B) Golgi bodies (C) Ribosomes (D) Lysosomes 
 
 
Q.5  Analysis of DNA sequences suggest that eukaryotic mitochondrial genomes primarily 
originated from   
(A) fungi  (B) protozoa  (C) algae  (D) bacteria 
 
 
Q.6  Binomial nomenclature has NOT yet been adopted for 
(A) bacteria (B) fungi (C) viruses (D) protozoa 
 
 
Q.7  Which of the following is NOT an accepted method for sterilization? 
(A) Autoclaving (B) X-rays 
(C) Gamma rays (D) UV rays 
 
 
Q.8  The primary product of nitrogen fixation is  
(A) N2 (B) NH4
+
 (C) NO2
?
 (D) NO3 
 
 
Q.9  In humans, the key stages in the life cycle of malarial parasites occur in 
(A) red blood cells and the liver 
(B) red blood cells and platelets 
(C) red blood cells and the pancreas 
(D) red blood cells and the gut 
GATE 2018    Microbiology (XL-S) 
XL-S 2/3 
 
Q.10  You have a 50 mg/mL stock solution of arginine. To prepare 1 liter of growth medium for 
an arginine auxotroph that requires 70 µg/mL of arginine, the volume of this stock solution 
that should be added is _____________ mL (up to 1 decimal point) . 
 
Q.11  Accumulating evidence suggest that Domain Archaea is more closely related to Domain 
Eukarya than to Domain Bacteria. Which of the following properties are shared between 
eukaryotes and archaea ? 
(i) Protein biogenesis  
(ii) Presence of sterol containing membranes 
(iii) Ribosomal subunit structures 
(iv) Adaptation to extreme environmental conditions 
(v) Fatty acids with ester linkages in the cell membrane 
(A) (ii), (iii) and (v) (B) (i), (ii), (iv), and (v) 
(C) (i) and (iii) (D) (iii) and (iv) 
 
 
Q.12  Match the antimicrobial agents in group I with their category/mode of action in group II.  
Group I Group II 
(i) Fluoroquinolones (p) beta lactam antimicrobial  
(ii) Amphotericin B (q) inhibition of protein synthesis 
(iii) Tetracycline  (r) inhibition of nucleic acid synthesis 
(iv) Amoxicillin (s) antifungal agent 
 
(A) (i)-(q), (ii)-(s), (iii)-(r), (iv)-(p) (B) (i)-(s), (ii)-(r), (iii)-(p), (iv)-(q) 
(C) (i)-(r), (ii)-(s), (iii)-(q), (iv)-(p) (D) (i)-(s), (ii)-(r), (iii)-(q), (iv)-(p) 
 
 
Q.13  Match the microorganisms to their predominant modes of transmission. 
 
 
Microorganism Mode of Transmission 
(i)  Bordetella pertussis (p)  Vector-borne 
(ii)  Dengue virus (q)  Blood-borne 
(iii)  Entamoeba histolytica (r)  Droplet infection 
(iv)  Hepatitis B virus (s)  Contaminated food 
(A) (i)-(r), (ii)-(p), (iii)-(s), (iv)-(q) (B) (i)-(s), (ii)-(q), (iii)-(p), (iv)-(r) 
(C) (i)-(q), (ii)-(p), (iii)-(s), (iv)-(r) (D) (i)-(s), (ii)-(r), (iii)-(p), (iv)-(q) 
 
 
Q.14  Match the precursors/intermediates with the corresponding metabolic pathways. 
Precursor/Intermediates Metabolic pathway 
(i)  Inosine monophosphate (p)  L-methionine biosynthesis 
(ii)  Ornithine (q)  L-tryptophan biosynthesis 
(iii)  Chorismate (r)  Purine biosynthesis 
(iv)  Homocysteine (s)  L-arginine biosynthesis 
 
(A) (i)-(q), (ii)-(r), (iii)-(s), (iv)-(p) (B) (i)-(p), (ii)-(r), (iii)-(s), (iv)-(q) 
(C) (i)-(r), (ii)-(p), (iii)-(s), (iv)-(q) (D) (i)-(r), (ii)-(s), (iii)-(q), (iv)-(p) 
 
 
Page 3


GATE 2018    Microbiology (XL-S) 
XL-S 1/3 
XL (S): Q. 1 – Q. 10 carry one mark each & Q. 11 – Q. 20 carry two marks each. 
Q.1  David Baltimore’s classification of viruses is based on differences in  
 (A) host cell receptors used by viruses  
(B) the pathways required to synthesize virus mRNA 
(C) the modes of transmission of viruses 
(D) the envelope proteins on the surface of viruses 
 
 
Q.2  Which of the following immune system components can function as an opsonin? 
(A) Antibodies (B) T-cell receptors 
(C) Histamines (D) Interferons 
 
 
Q.3  The oral polio vaccine (OPV) consists of 
(A) live attenuated virus (B) killed virus 
(C) viral toxin (D) viral capsid subunit 
 
 
Q.4  Which of the following eukaryotic cellular components carries out intracellular degradation 
during autophagy? 
(A) Nucleus (B) Golgi bodies (C) Ribosomes (D) Lysosomes 
 
 
Q.5  Analysis of DNA sequences suggest that eukaryotic mitochondrial genomes primarily 
originated from   
(A) fungi  (B) protozoa  (C) algae  (D) bacteria 
 
 
Q.6  Binomial nomenclature has NOT yet been adopted for 
(A) bacteria (B) fungi (C) viruses (D) protozoa 
 
 
Q.7  Which of the following is NOT an accepted method for sterilization? 
(A) Autoclaving (B) X-rays 
(C) Gamma rays (D) UV rays 
 
 
Q.8  The primary product of nitrogen fixation is  
(A) N2 (B) NH4
+
 (C) NO2
?
 (D) NO3 
 
 
Q.9  In humans, the key stages in the life cycle of malarial parasites occur in 
(A) red blood cells and the liver 
(B) red blood cells and platelets 
(C) red blood cells and the pancreas 
(D) red blood cells and the gut 
GATE 2018    Microbiology (XL-S) 
XL-S 2/3 
 
Q.10  You have a 50 mg/mL stock solution of arginine. To prepare 1 liter of growth medium for 
an arginine auxotroph that requires 70 µg/mL of arginine, the volume of this stock solution 
that should be added is _____________ mL (up to 1 decimal point) . 
 
Q.11  Accumulating evidence suggest that Domain Archaea is more closely related to Domain 
Eukarya than to Domain Bacteria. Which of the following properties are shared between 
eukaryotes and archaea ? 
(i) Protein biogenesis  
(ii) Presence of sterol containing membranes 
(iii) Ribosomal subunit structures 
(iv) Adaptation to extreme environmental conditions 
(v) Fatty acids with ester linkages in the cell membrane 
(A) (ii), (iii) and (v) (B) (i), (ii), (iv), and (v) 
(C) (i) and (iii) (D) (iii) and (iv) 
 
 
Q.12  Match the antimicrobial agents in group I with their category/mode of action in group II.  
Group I Group II 
(i) Fluoroquinolones (p) beta lactam antimicrobial  
(ii) Amphotericin B (q) inhibition of protein synthesis 
(iii) Tetracycline  (r) inhibition of nucleic acid synthesis 
(iv) Amoxicillin (s) antifungal agent 
 
(A) (i)-(q), (ii)-(s), (iii)-(r), (iv)-(p) (B) (i)-(s), (ii)-(r), (iii)-(p), (iv)-(q) 
(C) (i)-(r), (ii)-(s), (iii)-(q), (iv)-(p) (D) (i)-(s), (ii)-(r), (iii)-(q), (iv)-(p) 
 
 
Q.13  Match the microorganisms to their predominant modes of transmission. 
 
 
Microorganism Mode of Transmission 
(i)  Bordetella pertussis (p)  Vector-borne 
(ii)  Dengue virus (q)  Blood-borne 
(iii)  Entamoeba histolytica (r)  Droplet infection 
(iv)  Hepatitis B virus (s)  Contaminated food 
(A) (i)-(r), (ii)-(p), (iii)-(s), (iv)-(q) (B) (i)-(s), (ii)-(q), (iii)-(p), (iv)-(r) 
(C) (i)-(q), (ii)-(p), (iii)-(s), (iv)-(r) (D) (i)-(s), (ii)-(r), (iii)-(p), (iv)-(q) 
 
 
Q.14  Match the precursors/intermediates with the corresponding metabolic pathways. 
Precursor/Intermediates Metabolic pathway 
(i)  Inosine monophosphate (p)  L-methionine biosynthesis 
(ii)  Ornithine (q)  L-tryptophan biosynthesis 
(iii)  Chorismate (r)  Purine biosynthesis 
(iv)  Homocysteine (s)  L-arginine biosynthesis 
 
(A) (i)-(q), (ii)-(r), (iii)-(s), (iv)-(p) (B) (i)-(p), (ii)-(r), (iii)-(s), (iv)-(q) 
(C) (i)-(r), (ii)-(p), (iii)-(s), (iv)-(q) (D) (i)-(r), (ii)-(s), (iii)-(q), (iv)-(p) 
 
 
GATE 2018    Microbiology (XL-S) 
XL-S 3/3 
Q.15  Match the scientists to their area of major contribution 
Scientists Area of major contribution  
(i) Antonie van Leeuwenhoek (p) Taxonomy  
(ii) Carl Linnaeus (q) Antimicrobial agents  
(iii) Sir Alexander Fleming (r) Vaccination 
(iv) Louis Pasteur (s) Microscopy 
 
(A) (i)-(s), (ii)-(q), (iii)-(p), (iv)-(r) (B) (i)-(s), (ii)-(p), (iii)-(q), (iv)-(r) 
(C) (i)-(p), (ii)-(s), (iii)-(r), (iv)-(q) (D) (i)-(q), (ii)-(p), (iii)-(r), (iv)-(s) 
 
Q.16  Which of the following combinations would improve the resolution of a microscope? 
(i) Increasing the half aperture angle of the objective lens 
(ii) Decreasing the wavelength of the illumination source 
(iii) Decreasing the numerical aperture of the objective lens 
(iv) Decreasing the refractive index of immersion medium 
(A) (i) and (ii) (B) (ii) and (iii) (C) (ii) and (iv) (D) (i) and (iii) 
 
 
Q.17  Active transport involves the movement of a biomolecule against a concentration gradient 
across the cell membrane using metabolic energy. If the extracellular concentration of a 
biomolecule is 0.005M and its intracellular concentration is 0.5M, the least amount of 
energy that the cell would need to spend to transport this biomolecule from the outside to 
the inside of the cell is ________ kcal/mol (up to 2 decimal points). 
(Temperature T = 298K and universal gas constant R= 1.98 cal/mol ?K) 
 
Q.18  A continuous cell culture being carried out in a stirred tank 
reactor is described in terms of its cell mass concentration X 
and substrate concentration S. The concentration of the 
substrate in the sterile feed stream is SF = 10 g/L and yield 
coefficient Yx/s = 0.5. The flow rates of the feed stream and 
the exit stream are equal (F=5 mL/min) and constant. If the 
specific growth rate (h
-1
) ?? =
0.3 ?? (1+?? )
, the steady state 
concentration of S is _____ g/L (up to 1 decimal point). 
 
Q.19  The initial concentration of cells (N0) growing unrestricted in a culture is 1.0×10
6
 
cells/mL. If the specific growth rate (µ) of the cells is 0.1 h
-1
, the time required for the cell 
concentration to become 1.0×10
8
 cells/mL is _________ hours (up to 2 decimal points). 
 
Q.20  The following stoichiometric equation represents the conversion of glucose to lactic acid in 
a cell: 
Glucose + 2Pi + 2ADP ? 2Lactate + 2ATP +2H2O 
 
If the free energy of conversion of glucose to lactic acid only is ?G
0
 = ?47000 cal/mol, the 
efficiency of energy transfer is _______ % (up to 1 decimal point). 
(?G
0
 for ATP hydrolysis is ?7.3 kcal/mol) 
 
 
 
END OF THE QUESTION PAPER 
S
F
= 10 g/L
X, S
V = 3 L
Page 4


GATE 2018    Microbiology (XL-S) 
XL-S 1/3 
XL (S): Q. 1 – Q. 10 carry one mark each & Q. 11 – Q. 20 carry two marks each. 
Q.1  David Baltimore’s classification of viruses is based on differences in  
 (A) host cell receptors used by viruses  
(B) the pathways required to synthesize virus mRNA 
(C) the modes of transmission of viruses 
(D) the envelope proteins on the surface of viruses 
 
 
Q.2  Which of the following immune system components can function as an opsonin? 
(A) Antibodies (B) T-cell receptors 
(C) Histamines (D) Interferons 
 
 
Q.3  The oral polio vaccine (OPV) consists of 
(A) live attenuated virus (B) killed virus 
(C) viral toxin (D) viral capsid subunit 
 
 
Q.4  Which of the following eukaryotic cellular components carries out intracellular degradation 
during autophagy? 
(A) Nucleus (B) Golgi bodies (C) Ribosomes (D) Lysosomes 
 
 
Q.5  Analysis of DNA sequences suggest that eukaryotic mitochondrial genomes primarily 
originated from   
(A) fungi  (B) protozoa  (C) algae  (D) bacteria 
 
 
Q.6  Binomial nomenclature has NOT yet been adopted for 
(A) bacteria (B) fungi (C) viruses (D) protozoa 
 
 
Q.7  Which of the following is NOT an accepted method for sterilization? 
(A) Autoclaving (B) X-rays 
(C) Gamma rays (D) UV rays 
 
 
Q.8  The primary product of nitrogen fixation is  
(A) N2 (B) NH4
+
 (C) NO2
?
 (D) NO3 
 
 
Q.9  In humans, the key stages in the life cycle of malarial parasites occur in 
(A) red blood cells and the liver 
(B) red blood cells and platelets 
(C) red blood cells and the pancreas 
(D) red blood cells and the gut 
GATE 2018    Microbiology (XL-S) 
XL-S 2/3 
 
Q.10  You have a 50 mg/mL stock solution of arginine. To prepare 1 liter of growth medium for 
an arginine auxotroph that requires 70 µg/mL of arginine, the volume of this stock solution 
that should be added is _____________ mL (up to 1 decimal point) . 
 
Q.11  Accumulating evidence suggest that Domain Archaea is more closely related to Domain 
Eukarya than to Domain Bacteria. Which of the following properties are shared between 
eukaryotes and archaea ? 
(i) Protein biogenesis  
(ii) Presence of sterol containing membranes 
(iii) Ribosomal subunit structures 
(iv) Adaptation to extreme environmental conditions 
(v) Fatty acids with ester linkages in the cell membrane 
(A) (ii), (iii) and (v) (B) (i), (ii), (iv), and (v) 
(C) (i) and (iii) (D) (iii) and (iv) 
 
 
Q.12  Match the antimicrobial agents in group I with their category/mode of action in group II.  
Group I Group II 
(i) Fluoroquinolones (p) beta lactam antimicrobial  
(ii) Amphotericin B (q) inhibition of protein synthesis 
(iii) Tetracycline  (r) inhibition of nucleic acid synthesis 
(iv) Amoxicillin (s) antifungal agent 
 
(A) (i)-(q), (ii)-(s), (iii)-(r), (iv)-(p) (B) (i)-(s), (ii)-(r), (iii)-(p), (iv)-(q) 
(C) (i)-(r), (ii)-(s), (iii)-(q), (iv)-(p) (D) (i)-(s), (ii)-(r), (iii)-(q), (iv)-(p) 
 
 
Q.13  Match the microorganisms to their predominant modes of transmission. 
 
 
Microorganism Mode of Transmission 
(i)  Bordetella pertussis (p)  Vector-borne 
(ii)  Dengue virus (q)  Blood-borne 
(iii)  Entamoeba histolytica (r)  Droplet infection 
(iv)  Hepatitis B virus (s)  Contaminated food 
(A) (i)-(r), (ii)-(p), (iii)-(s), (iv)-(q) (B) (i)-(s), (ii)-(q), (iii)-(p), (iv)-(r) 
(C) (i)-(q), (ii)-(p), (iii)-(s), (iv)-(r) (D) (i)-(s), (ii)-(r), (iii)-(p), (iv)-(q) 
 
 
Q.14  Match the precursors/intermediates with the corresponding metabolic pathways. 
Precursor/Intermediates Metabolic pathway 
(i)  Inosine monophosphate (p)  L-methionine biosynthesis 
(ii)  Ornithine (q)  L-tryptophan biosynthesis 
(iii)  Chorismate (r)  Purine biosynthesis 
(iv)  Homocysteine (s)  L-arginine biosynthesis 
 
(A) (i)-(q), (ii)-(r), (iii)-(s), (iv)-(p) (B) (i)-(p), (ii)-(r), (iii)-(s), (iv)-(q) 
(C) (i)-(r), (ii)-(p), (iii)-(s), (iv)-(q) (D) (i)-(r), (ii)-(s), (iii)-(q), (iv)-(p) 
 
 
GATE 2018    Microbiology (XL-S) 
XL-S 3/3 
Q.15  Match the scientists to their area of major contribution 
Scientists Area of major contribution  
(i) Antonie van Leeuwenhoek (p) Taxonomy  
(ii) Carl Linnaeus (q) Antimicrobial agents  
(iii) Sir Alexander Fleming (r) Vaccination 
(iv) Louis Pasteur (s) Microscopy 
 
(A) (i)-(s), (ii)-(q), (iii)-(p), (iv)-(r) (B) (i)-(s), (ii)-(p), (iii)-(q), (iv)-(r) 
(C) (i)-(p), (ii)-(s), (iii)-(r), (iv)-(q) (D) (i)-(q), (ii)-(p), (iii)-(r), (iv)-(s) 
 
Q.16  Which of the following combinations would improve the resolution of a microscope? 
(i) Increasing the half aperture angle of the objective lens 
(ii) Decreasing the wavelength of the illumination source 
(iii) Decreasing the numerical aperture of the objective lens 
(iv) Decreasing the refractive index of immersion medium 
(A) (i) and (ii) (B) (ii) and (iii) (C) (ii) and (iv) (D) (i) and (iii) 
 
 
Q.17  Active transport involves the movement of a biomolecule against a concentration gradient 
across the cell membrane using metabolic energy. If the extracellular concentration of a 
biomolecule is 0.005M and its intracellular concentration is 0.5M, the least amount of 
energy that the cell would need to spend to transport this biomolecule from the outside to 
the inside of the cell is ________ kcal/mol (up to 2 decimal points). 
(Temperature T = 298K and universal gas constant R= 1.98 cal/mol ?K) 
 
Q.18  A continuous cell culture being carried out in a stirred tank 
reactor is described in terms of its cell mass concentration X 
and substrate concentration S. The concentration of the 
substrate in the sterile feed stream is SF = 10 g/L and yield 
coefficient Yx/s = 0.5. The flow rates of the feed stream and 
the exit stream are equal (F=5 mL/min) and constant. If the 
specific growth rate (h
-1
) ?? =
0.3 ?? (1+?? )
, the steady state 
concentration of S is _____ g/L (up to 1 decimal point). 
 
Q.19  The initial concentration of cells (N0) growing unrestricted in a culture is 1.0×10
6
 
cells/mL. If the specific growth rate (µ) of the cells is 0.1 h
-1
, the time required for the cell 
concentration to become 1.0×10
8
 cells/mL is _________ hours (up to 2 decimal points). 
 
Q.20  The following stoichiometric equation represents the conversion of glucose to lactic acid in 
a cell: 
Glucose + 2Pi + 2ADP ? 2Lactate + 2ATP +2H2O 
 
If the free energy of conversion of glucose to lactic acid only is ?G
0
 = ?47000 cal/mol, the 
efficiency of energy transfer is _______ % (up to 1 decimal point). 
(?G
0
 for ATP hydrolysis is ?7.3 kcal/mol) 
 
 
 
END OF THE QUESTION PAPER 
S
F
= 10 g/L
X, S
V = 3 L
Q.No. Type Section Key/Range Marks
1 MCQ GA A 1
2 MCQ GA C 1
3 MCQ GA B 1
4 MCQ GA B 1
5 MCQ GA B 1
6 MCQ GA A 2
7 MCQ GA D 2
8 MCQ GA D 2
9 MCQ GA B 2
10 MCQ GA C 2
1 MCQ XL-PA 1
2 MCQ XL-PD 1
3 MCQ XL-PD 1
4 NAT XL-P11 to 11 1
5 NAT XL-P4 to 41
6 MCQ XL-PD 2
7 MCQ XL-PD 2
8 MCQ XL-PA 2
9 MCQ XL-PD 2
10 MCQ XL-PA 2
11 MCQ XL-PC 2
12 MCQ XL-PB 2
13 NAT XL-P 1.39 to 1.43 2
Page 5


GATE 2018    Microbiology (XL-S) 
XL-S 1/3 
XL (S): Q. 1 – Q. 10 carry one mark each & Q. 11 – Q. 20 carry two marks each. 
Q.1  David Baltimore’s classification of viruses is based on differences in  
 (A) host cell receptors used by viruses  
(B) the pathways required to synthesize virus mRNA 
(C) the modes of transmission of viruses 
(D) the envelope proteins on the surface of viruses 
 
 
Q.2  Which of the following immune system components can function as an opsonin? 
(A) Antibodies (B) T-cell receptors 
(C) Histamines (D) Interferons 
 
 
Q.3  The oral polio vaccine (OPV) consists of 
(A) live attenuated virus (B) killed virus 
(C) viral toxin (D) viral capsid subunit 
 
 
Q.4  Which of the following eukaryotic cellular components carries out intracellular degradation 
during autophagy? 
(A) Nucleus (B) Golgi bodies (C) Ribosomes (D) Lysosomes 
 
 
Q.5  Analysis of DNA sequences suggest that eukaryotic mitochondrial genomes primarily 
originated from   
(A) fungi  (B) protozoa  (C) algae  (D) bacteria 
 
 
Q.6  Binomial nomenclature has NOT yet been adopted for 
(A) bacteria (B) fungi (C) viruses (D) protozoa 
 
 
Q.7  Which of the following is NOT an accepted method for sterilization? 
(A) Autoclaving (B) X-rays 
(C) Gamma rays (D) UV rays 
 
 
Q.8  The primary product of nitrogen fixation is  
(A) N2 (B) NH4
+
 (C) NO2
?
 (D) NO3 
 
 
Q.9  In humans, the key stages in the life cycle of malarial parasites occur in 
(A) red blood cells and the liver 
(B) red blood cells and platelets 
(C) red blood cells and the pancreas 
(D) red blood cells and the gut 
GATE 2018    Microbiology (XL-S) 
XL-S 2/3 
 
Q.10  You have a 50 mg/mL stock solution of arginine. To prepare 1 liter of growth medium for 
an arginine auxotroph that requires 70 µg/mL of arginine, the volume of this stock solution 
that should be added is _____________ mL (up to 1 decimal point) . 
 
Q.11  Accumulating evidence suggest that Domain Archaea is more closely related to Domain 
Eukarya than to Domain Bacteria. Which of the following properties are shared between 
eukaryotes and archaea ? 
(i) Protein biogenesis  
(ii) Presence of sterol containing membranes 
(iii) Ribosomal subunit structures 
(iv) Adaptation to extreme environmental conditions 
(v) Fatty acids with ester linkages in the cell membrane 
(A) (ii), (iii) and (v) (B) (i), (ii), (iv), and (v) 
(C) (i) and (iii) (D) (iii) and (iv) 
 
 
Q.12  Match the antimicrobial agents in group I with their category/mode of action in group II.  
Group I Group II 
(i) Fluoroquinolones (p) beta lactam antimicrobial  
(ii) Amphotericin B (q) inhibition of protein synthesis 
(iii) Tetracycline  (r) inhibition of nucleic acid synthesis 
(iv) Amoxicillin (s) antifungal agent 
 
(A) (i)-(q), (ii)-(s), (iii)-(r), (iv)-(p) (B) (i)-(s), (ii)-(r), (iii)-(p), (iv)-(q) 
(C) (i)-(r), (ii)-(s), (iii)-(q), (iv)-(p) (D) (i)-(s), (ii)-(r), (iii)-(q), (iv)-(p) 
 
 
Q.13  Match the microorganisms to their predominant modes of transmission. 
 
 
Microorganism Mode of Transmission 
(i)  Bordetella pertussis (p)  Vector-borne 
(ii)  Dengue virus (q)  Blood-borne 
(iii)  Entamoeba histolytica (r)  Droplet infection 
(iv)  Hepatitis B virus (s)  Contaminated food 
(A) (i)-(r), (ii)-(p), (iii)-(s), (iv)-(q) (B) (i)-(s), (ii)-(q), (iii)-(p), (iv)-(r) 
(C) (i)-(q), (ii)-(p), (iii)-(s), (iv)-(r) (D) (i)-(s), (ii)-(r), (iii)-(p), (iv)-(q) 
 
 
Q.14  Match the precursors/intermediates with the corresponding metabolic pathways. 
Precursor/Intermediates Metabolic pathway 
(i)  Inosine monophosphate (p)  L-methionine biosynthesis 
(ii)  Ornithine (q)  L-tryptophan biosynthesis 
(iii)  Chorismate (r)  Purine biosynthesis 
(iv)  Homocysteine (s)  L-arginine biosynthesis 
 
(A) (i)-(q), (ii)-(r), (iii)-(s), (iv)-(p) (B) (i)-(p), (ii)-(r), (iii)-(s), (iv)-(q) 
(C) (i)-(r), (ii)-(p), (iii)-(s), (iv)-(q) (D) (i)-(r), (ii)-(s), (iii)-(q), (iv)-(p) 
 
 
GATE 2018    Microbiology (XL-S) 
XL-S 3/3 
Q.15  Match the scientists to their area of major contribution 
Scientists Area of major contribution  
(i) Antonie van Leeuwenhoek (p) Taxonomy  
(ii) Carl Linnaeus (q) Antimicrobial agents  
(iii) Sir Alexander Fleming (r) Vaccination 
(iv) Louis Pasteur (s) Microscopy 
 
(A) (i)-(s), (ii)-(q), (iii)-(p), (iv)-(r) (B) (i)-(s), (ii)-(p), (iii)-(q), (iv)-(r) 
(C) (i)-(p), (ii)-(s), (iii)-(r), (iv)-(q) (D) (i)-(q), (ii)-(p), (iii)-(r), (iv)-(s) 
 
Q.16  Which of the following combinations would improve the resolution of a microscope? 
(i) Increasing the half aperture angle of the objective lens 
(ii) Decreasing the wavelength of the illumination source 
(iii) Decreasing the numerical aperture of the objective lens 
(iv) Decreasing the refractive index of immersion medium 
(A) (i) and (ii) (B) (ii) and (iii) (C) (ii) and (iv) (D) (i) and (iii) 
 
 
Q.17  Active transport involves the movement of a biomolecule against a concentration gradient 
across the cell membrane using metabolic energy. If the extracellular concentration of a 
biomolecule is 0.005M and its intracellular concentration is 0.5M, the least amount of 
energy that the cell would need to spend to transport this biomolecule from the outside to 
the inside of the cell is ________ kcal/mol (up to 2 decimal points). 
(Temperature T = 298K and universal gas constant R= 1.98 cal/mol ?K) 
 
Q.18  A continuous cell culture being carried out in a stirred tank 
reactor is described in terms of its cell mass concentration X 
and substrate concentration S. The concentration of the 
substrate in the sterile feed stream is SF = 10 g/L and yield 
coefficient Yx/s = 0.5. The flow rates of the feed stream and 
the exit stream are equal (F=5 mL/min) and constant. If the 
specific growth rate (h
-1
) ?? =
0.3 ?? (1+?? )
, the steady state 
concentration of S is _____ g/L (up to 1 decimal point). 
 
Q.19  The initial concentration of cells (N0) growing unrestricted in a culture is 1.0×10
6
 
cells/mL. If the specific growth rate (µ) of the cells is 0.1 h
-1
, the time required for the cell 
concentration to become 1.0×10
8
 cells/mL is _________ hours (up to 2 decimal points). 
 
Q.20  The following stoichiometric equation represents the conversion of glucose to lactic acid in 
a cell: 
Glucose + 2Pi + 2ADP ? 2Lactate + 2ATP +2H2O 
 
If the free energy of conversion of glucose to lactic acid only is ?G
0
 = ?47000 cal/mol, the 
efficiency of energy transfer is _______ % (up to 1 decimal point). 
(?G
0
 for ATP hydrolysis is ?7.3 kcal/mol) 
 
 
 
END OF THE QUESTION PAPER 
S
F
= 10 g/L
X, S
V = 3 L
Q.No. Type Section Key/Range Marks
1 MCQ GA A 1
2 MCQ GA C 1
3 MCQ GA B 1
4 MCQ GA B 1
5 MCQ GA B 1
6 MCQ GA A 2
7 MCQ GA D 2
8 MCQ GA D 2
9 MCQ GA B 2
10 MCQ GA C 2
1 MCQ XL-PA 1
2 MCQ XL-PD 1
3 MCQ XL-PD 1
4 NAT XL-P11 to 11 1
5 NAT XL-P4 to 41
6 MCQ XL-PD 2
7 MCQ XL-PD 2
8 MCQ XL-PA 2
9 MCQ XL-PD 2
10 MCQ XL-PA 2
11 MCQ XL-PC 2
12 MCQ XL-PB 2
13 NAT XL-P 1.39 to 1.43 2
Q.No. Type Section Key/Range Marks
14 NAT XL-P 7.39 to 7.54 2
15 NAT XL-P -13.40 to -13.36 2
1 MCQ XL-QB 1
2 MCQ XL-QA 1
3 MCQ XL-QC 1
4 MCQ XL-QC 1
5 MCQ XL-QD 1
6 MCQ XL-QC 1
7 MCQ XL-QD 1
8 MCQ XL-QB 1
9 NAT XL-Q12 to 12 1
10 NAT XL-Q50 to 50 1
11 MCQ XL-QA 2
12 MCQ XL-QA 2
13 MCQ XL-QD 2
14 MCQ XL-QB 2
15 MCQ XL-QB 2
16 NAT XL-Q 512 to 512 2
17 NAT XL-Q20 to 20 2
18 NAT XL-Q 0.8 to 0.8 2
19 NAT XL-Q77 to 77 2
20 NAT XL-Q -8862 to -8862 2
1 MCQ XL-RA 1
Read More
Offer running on EduRev: Apply code STAYHOME200 to get INR 200 off on our premium plan EduRev Infinity!

Related Searches

Exam

,

Previous Year Questions with Solutions

,

shortcuts and tricks

,

Viva Questions

,

practice quizzes

,

pdf

,

ppt

,

Extra Questions

,

past year papers

,

MCQs

,

Objective type Questions

,

Summary

,

Life Sciences - XL 2018 GATE Paper with solution - Set - 4 GATE Notes | EduRev

,

mock tests for examination

,

Life Sciences - XL 2018 GATE Paper with solution - Set - 4 GATE Notes | EduRev

,

video lectures

,

Sample Paper

,

Free

,

study material

,

Important questions

,

Semester Notes

,

Life Sciences - XL 2018 GATE Paper with solution - Set - 4 GATE Notes | EduRev

;