Neural Plasticity: Long-term Depression Lesson 16 Neural Plasticity: Notes | EduRev

: Neural Plasticity: Long-term Depression Lesson 16 Neural Plasticity: Notes | EduRev

 Page 1


Neural Plasticity: 
Long-term 
Depression 
Lesson 16 
Page 2


Neural Plasticity: 
Long-term 
Depression 
Lesson 16 
Long-term Depression 
? Hippocampus 
? Low frequency stimulation  
? 1 Hz over 10-15 min  
? NMDA & Ca
2+
 -dependent 
? Low Ca
2+
  ? ? phosphatase activity 
? Cerebellum 
? mGlu1-R  
? Different mechanism ~ 
 
Page 3


Neural Plasticity: 
Long-term 
Depression 
Lesson 16 
Long-term Depression 
? Hippocampus 
? Low frequency stimulation  
? 1 Hz over 10-15 min  
? NMDA & Ca
2+
 -dependent 
? Low Ca
2+
  ? ? phosphatase activity 
? Cerebellum 
? mGlu1-R  
? Different mechanism ~ 
 
Cerebellum 
? Motor functions 
? Coordination of movements 
? Regulation of posture  
? Indirect control  
? Adjust outputs of descending tracts  
? Also nonmotor functions   
? memory/language ~ 
Page 4


Neural Plasticity: 
Long-term 
Depression 
Lesson 16 
Long-term Depression 
? Hippocampus 
? Low frequency stimulation  
? 1 Hz over 10-15 min  
? NMDA & Ca
2+
 -dependent 
? Low Ca
2+
  ? ? phosphatase activity 
? Cerebellum 
? mGlu1-R  
? Different mechanism ~ 
 
Cerebellum 
? Motor functions 
? Coordination of movements 
? Regulation of posture  
? Indirect control  
? Adjust outputs of descending tracts  
? Also nonmotor functions   
? memory/language ~ 
Cerebellum: Anatomy 
? Folia & lobules 
? analogous gyri & lobes 
? Vermis - along midline 
? output ? ventromedial pathway  
? Hemispheres 
? output ? lateral pathway 
? Deep cerebellar nuclei  
? fastigial, interposed, & dentate 
? Major output structures ~ 
Page 5


Neural Plasticity: 
Long-term 
Depression 
Lesson 16 
Long-term Depression 
? Hippocampus 
? Low frequency stimulation  
? 1 Hz over 10-15 min  
? NMDA & Ca
2+
 -dependent 
? Low Ca
2+
  ? ? phosphatase activity 
? Cerebellum 
? mGlu1-R  
? Different mechanism ~ 
 
Cerebellum 
? Motor functions 
? Coordination of movements 
? Regulation of posture  
? Indirect control  
? Adjust outputs of descending tracts  
? Also nonmotor functions   
? memory/language ~ 
Cerebellum: Anatomy 
? Folia & lobules 
? analogous gyri & lobes 
? Vermis - along midline 
? output ? ventromedial pathway  
? Hemispheres 
? output ? lateral pathway 
? Deep cerebellar nuclei  
? fastigial, interposed, & dentate 
? Major output structures ~ 
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