Neural Plasticity: Long-term Potentiation Lesson 15 Neural Plasticity: Notes | EduRev

: Neural Plasticity: Long-term Potentiation Lesson 15 Neural Plasticity: Notes | EduRev

 Page 1


Neural Plasticity: 
Long-term 
Potentiation 
Lesson 15 
Page 2


Neural Plasticity: 
Long-term 
Potentiation 
Lesson 15 
Neural Plasticity 
? Nervous System is malleable 
? learning occurs 
? Structural changes at synapses 
? Changes in synaptic efficiency 
? Long-term potentiation 
? Long-term depression  
? LTP & LTD throughout brain  
? Many different mechanisms ~ 
Page 3


Neural Plasticity: 
Long-term 
Potentiation 
Lesson 15 
Neural Plasticity 
? Nervous System is malleable 
? learning occurs 
? Structural changes at synapses 
? Changes in synaptic efficiency 
? Long-term potentiation 
? Long-term depression  
? LTP & LTD throughout brain  
? Many different mechanisms ~ 
Neural Mechanism of Memory 
? Donald Hebb  
? Short-term Memory  
? Change in neural activity 
? not structural  
? temporary 
? Reverberatory Circuits -  
? cortical loops of activity ~ 
Page 4


Neural Plasticity: 
Long-term 
Potentiation 
Lesson 15 
Neural Plasticity 
? Nervous System is malleable 
? learning occurs 
? Structural changes at synapses 
? Changes in synaptic efficiency 
? Long-term potentiation 
? Long-term depression  
? LTP & LTD throughout brain  
? Many different mechanisms ~ 
Neural Mechanism of Memory 
? Donald Hebb  
? Short-term Memory  
? Change in neural activity 
? not structural  
? temporary 
? Reverberatory Circuits -  
? cortical loops of activity ~ 
Reverberating Loops 
? Maintains neural activity for a period 
? Activity decays ~ 
Page 5


Neural Plasticity: 
Long-term 
Potentiation 
Lesson 15 
Neural Plasticity 
? Nervous System is malleable 
? learning occurs 
? Structural changes at synapses 
? Changes in synaptic efficiency 
? Long-term potentiation 
? Long-term depression  
? LTP & LTD throughout brain  
? Many different mechanisms ~ 
Neural Mechanism of Memory 
? Donald Hebb  
? Short-term Memory  
? Change in neural activity 
? not structural  
? temporary 
? Reverberatory Circuits -  
? cortical loops of activity ~ 
Reverberating Loops 
? Maintains neural activity for a period 
? Activity decays ~ 
Hebb’s Postulate 
? Long-Term Memory 
? required structural change in brain 
? relatively permanent 
? Hebb Synapse 
? use strengthens synaptic efficiency 
? concurrent activity required 
• pre- & postsynaptic neurons ~ 
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