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Cystic fibrosis is a genetic disorder caused by a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. CFTR is responsible for regulating chloride transport in various organs, including the lungs, liver, intestine, and pancreas. This regulation is essential for the production of mucus, sweat, and digestive fluids. When CFTR is dysfunctional, it disrupts the transport of salt and water in and out of cells, resulting in the accumulation of thick mucus in the lungs and digestive tract. This condition leads to difficulties in breathing, frequent lung and sinus infections, and other complications. At the cellular level, excess water is likely to be trapped in individuals with cystic fibrosis.

Question for Practice Passage Test - 3
Try yourself:Cystic fibrosis is caused by a mutation in the gene called:
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Question for Practice Passage Test - 3
Try yourself:What is the role of CFTR in the body?
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Question for Practice Passage Test - 3
Try yourself:What is the main consequence of CFTR dysfunction in cystic fibrosis?
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Question for Practice Passage Test - 3
Try yourself:How does cystic fibrosis affect breathing?
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Question for Practice Passage Test - 3
Try yourself:Which of the following is NOT a location where CFTR regulates chloride transport?
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