Protein Structures MBBS Notes | EduRev

MBBS : Protein Structures MBBS Notes | EduRev

 Page 1


Protein structures
Page 2


Protein structures
Protein Structure Protein Structure
• Why protein structure?
• The basics of protein p
• Basic measurements for protein structure
• Levels of protein structure • Levels of protein structure
• Prediction of protein structure from sequence
• Finding similarities between protein structures
• Classification of protein structures
Page 3


Protein structures
Protein Structure Protein Structure
• Why protein structure?
• The basics of protein p
• Basic measurements for protein structure
• Levels of protein structure • Levels of protein structure
• Prediction of protein structure from sequence
• Finding similarities between protein structures
• Classification of protein structures
Wh t i t t ? Why protein structure?
Ith f t flii ll ti th k • In the factory of living cells, proteins are the workers, 
performing a variety of biological tasks.
• Each protein has a particular 3 D structure that • Each protein has a particular 3-D structure that 
determines its function.
• Protein structure is more conserved than protein • Protein structure is more conserved than protein 
sequence, and more closely related to function.
Page 4


Protein structures
Protein Structure Protein Structure
• Why protein structure?
• The basics of protein p
• Basic measurements for protein structure
• Levels of protein structure • Levels of protein structure
• Prediction of protein structure from sequence
• Finding similarities between protein structures
• Classification of protein structures
Wh t i t t ? Why protein structure?
Ith f t flii ll ti th k • In the factory of living cells, proteins are the workers, 
performing a variety of biological tasks.
• Each protein has a particular 3 D structure that • Each protein has a particular 3-D structure that 
determines its function.
• Protein structure is more conserved than protein • Protein structure is more conserved than protein 
sequence, and more closely related to function.
Structural information Structural information
PiD B k i i db hR hCllb f • Protein Data Bank: maintained by the Research Collaboratory of 
Structural Bioinformatics(RCSB)
• http://www rcsb org/pdb/ http://www.rcsb.org/pdb/
• > 42752 protein structures as of April 10
• including structures of Protein/Nucleic Acid Complexes, including structures of Protein/Nucleic Acid Complexes, 
Nucleic Acids, Carbohydrates
• Most structures are determined by X-ray crystallography. Other 
th d NMR d l t i (EM) Th ti ll methods are NMR and electron microscopy(EM). Theoretically 
predicted structures were removed from PDB a few years ago.
Page 5


Protein structures
Protein Structure Protein Structure
• Why protein structure?
• The basics of protein p
• Basic measurements for protein structure
• Levels of protein structure • Levels of protein structure
• Prediction of protein structure from sequence
• Finding similarities between protein structures
• Classification of protein structures
Wh t i t t ? Why protein structure?
Ith f t flii ll ti th k • In the factory of living cells, proteins are the workers, 
performing a variety of biological tasks.
• Each protein has a particular 3 D structure that • Each protein has a particular 3-D structure that 
determines its function.
• Protein structure is more conserved than protein • Protein structure is more conserved than protein 
sequence, and more closely related to function.
Structural information Structural information
PiD B k i i db hR hCllb f • Protein Data Bank: maintained by the Research Collaboratory of 
Structural Bioinformatics(RCSB)
• http://www rcsb org/pdb/ http://www.rcsb.org/pdb/
• > 42752 protein structures as of April 10
• including structures of Protein/Nucleic Acid Complexes, including structures of Protein/Nucleic Acid Complexes, 
Nucleic Acids, Carbohydrates
• Most structures are determined by X-ray crystallography. Other 
th d NMR d l t i (EM) Th ti ll methods are NMR and electron microscopy(EM). Theoretically 
predicted structures were removed from PDB a few years ago.
PDB Growth PDB Growth
Red: Total
Blue: Yearly Blue: Yearly
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