Page 1
76
7. SCIENCE AND TECHNOLOGY
7.1. SPACE TOURISM
Why in news?
Several private companies are developing plans to take paying customers to space on a regular basis leading to a
rapid growth in space tourism industry.
About Space Tourism
• Space tourism is space travel for recreational, leisure or business purposes. There are several different
types of space tourism, including orbital, suborbital and lunar space tourism.
o To date, orbital space tourism has been performed only by the Russian Aviation and Space Agency
known as the Roscosmos State Corporation for Space Activities or Roscosmos.
o Several private spaceflight companies are now working towards developing suborbital space tourism
vehicles to take paying customers to space (Refer infographic).
What do we call space and space travel?
• According to the Fédération Aéronautique
Internationale (world governing body for
aeronautic and astronautic records), space
starts at an altitude of 100 km (62 miles) above
the surface of the earth.
o This is the Karman line where atmospheric
lift no longer supports a flying object and
the object would need to reach orbital
velocity or risk falling back to Earth.
• Space travel is referred to as any flight
operation that takes one or more passengers
beyond the altitude of 100 km and thus into
space.
• The main difference between orbital and
suborbital flight is the speed at which a vehicle
is traveling.
o An orbital spacecraft must achieve orbital
velocity i.e. the speed that an object must
maintain to remain in orbit around a planet.
To orbit 125 miles (200 kilometers) above
Earth for instance, a spacecraft must travel
at a screaming 17,400 mph (28,000 km/h).
o Suborbital flight, in contrast, requires
much lower speeds and doesn't have the
power to achieve orbit. Instead, it will fly up
to a certain height that depends on its
speed, and then come back down once its
engines are shut off.
o At the top of their flight arc in a suborbital flight, when the object is falling back toward Earth, passengers
achieve a few minutes of weightlessness under zero gravity.
Page 2
76
7. SCIENCE AND TECHNOLOGY
7.1. SPACE TOURISM
Why in news?
Several private companies are developing plans to take paying customers to space on a regular basis leading to a
rapid growth in space tourism industry.
About Space Tourism
• Space tourism is space travel for recreational, leisure or business purposes. There are several different
types of space tourism, including orbital, suborbital and lunar space tourism.
o To date, orbital space tourism has been performed only by the Russian Aviation and Space Agency
known as the Roscosmos State Corporation for Space Activities or Roscosmos.
o Several private spaceflight companies are now working towards developing suborbital space tourism
vehicles to take paying customers to space (Refer infographic).
What do we call space and space travel?
• According to the Fédération Aéronautique
Internationale (world governing body for
aeronautic and astronautic records), space
starts at an altitude of 100 km (62 miles) above
the surface of the earth.
o This is the Karman line where atmospheric
lift no longer supports a flying object and
the object would need to reach orbital
velocity or risk falling back to Earth.
• Space travel is referred to as any flight
operation that takes one or more passengers
beyond the altitude of 100 km and thus into
space.
• The main difference between orbital and
suborbital flight is the speed at which a vehicle
is traveling.
o An orbital spacecraft must achieve orbital
velocity i.e. the speed that an object must
maintain to remain in orbit around a planet.
To orbit 125 miles (200 kilometers) above
Earth for instance, a spacecraft must travel
at a screaming 17,400 mph (28,000 km/h).
o Suborbital flight, in contrast, requires
much lower speeds and doesn't have the
power to achieve orbit. Instead, it will fly up
to a certain height that depends on its
speed, and then come back down once its
engines are shut off.
o At the top of their flight arc in a suborbital flight, when the object is falling back toward Earth, passengers
achieve a few minutes of weightlessness under zero gravity.
77
Key market drivers for space tourism
• The space tourism market is forecast to reach $1.3bn by 2025,
growing at a CAGR 12.4% during forecast period, 2020-2025.
Major factors accounting for the same are:
o Decline in the cost of space tourism: The total cost of a trip
into space has reduced significantly from the initial price
level of about $600 000 to $250,000 estimated to decline
further to $2000 per kilogram over coming years.
o Technological advancements: such as development of
suborbital reusable launch vehicles that is also the key to
Lowering Spaceflight Costs. Companies such as Virgin
Galactic and Blue Origin are testing suborbital flights that
can carry space tourists and researchers at altitudes
between 50 and 68 miles.
o International Interest in Space Tourism: While the bulk of
space tourism industry activities is centered in the United
States, several countries are looking to tap into the market.
o Development of space accommodations: In June 2019,
NASA announced plans to allow private citizens to fly to the
ISS with stay for short visits. Many private entities are also
developing hotels in space for tourists’ stay.
? For instance, Orion Span has announced a plan to build world’s first luxury hotel in space Aurora
Station to be built by 2021.
Issues with respect to emerging space tourism industry
Space tourism is a unique venture, and thus, the legality of activities around the proliferation of individuals in
space for recreation is yet to be formulated. The current treaties relating to space are extremely outdated and
fail to copiously deal with the legal challenges imposed by the space tourism industry. Various issues that arise
are:
Page 3
76
7. SCIENCE AND TECHNOLOGY
7.1. SPACE TOURISM
Why in news?
Several private companies are developing plans to take paying customers to space on a regular basis leading to a
rapid growth in space tourism industry.
About Space Tourism
• Space tourism is space travel for recreational, leisure or business purposes. There are several different
types of space tourism, including orbital, suborbital and lunar space tourism.
o To date, orbital space tourism has been performed only by the Russian Aviation and Space Agency
known as the Roscosmos State Corporation for Space Activities or Roscosmos.
o Several private spaceflight companies are now working towards developing suborbital space tourism
vehicles to take paying customers to space (Refer infographic).
What do we call space and space travel?
• According to the Fédération Aéronautique
Internationale (world governing body for
aeronautic and astronautic records), space
starts at an altitude of 100 km (62 miles) above
the surface of the earth.
o This is the Karman line where atmospheric
lift no longer supports a flying object and
the object would need to reach orbital
velocity or risk falling back to Earth.
• Space travel is referred to as any flight
operation that takes one or more passengers
beyond the altitude of 100 km and thus into
space.
• The main difference between orbital and
suborbital flight is the speed at which a vehicle
is traveling.
o An orbital spacecraft must achieve orbital
velocity i.e. the speed that an object must
maintain to remain in orbit around a planet.
To orbit 125 miles (200 kilometers) above
Earth for instance, a spacecraft must travel
at a screaming 17,400 mph (28,000 km/h).
o Suborbital flight, in contrast, requires
much lower speeds and doesn't have the
power to achieve orbit. Instead, it will fly up
to a certain height that depends on its
speed, and then come back down once its
engines are shut off.
o At the top of their flight arc in a suborbital flight, when the object is falling back toward Earth, passengers
achieve a few minutes of weightlessness under zero gravity.
77
Key market drivers for space tourism
• The space tourism market is forecast to reach $1.3bn by 2025,
growing at a CAGR 12.4% during forecast period, 2020-2025.
Major factors accounting for the same are:
o Decline in the cost of space tourism: The total cost of a trip
into space has reduced significantly from the initial price
level of about $600 000 to $250,000 estimated to decline
further to $2000 per kilogram over coming years.
o Technological advancements: such as development of
suborbital reusable launch vehicles that is also the key to
Lowering Spaceflight Costs. Companies such as Virgin
Galactic and Blue Origin are testing suborbital flights that
can carry space tourists and researchers at altitudes
between 50 and 68 miles.
o International Interest in Space Tourism: While the bulk of
space tourism industry activities is centered in the United
States, several countries are looking to tap into the market.
o Development of space accommodations: In June 2019,
NASA announced plans to allow private citizens to fly to the
ISS with stay for short visits. Many private entities are also
developing hotels in space for tourists’ stay.
? For instance, Orion Span has announced a plan to build world’s first luxury hotel in space Aurora
Station to be built by 2021.
Issues with respect to emerging space tourism industry
Space tourism is a unique venture, and thus, the legality of activities around the proliferation of individuals in
space for recreation is yet to be formulated. The current treaties relating to space are extremely outdated and
fail to copiously deal with the legal challenges imposed by the space tourism industry. Various issues that arise
are:
78
India’s venture into space tourism
• The Indian Space Research Organization’s Gaganyan
mission (primary manned mission to space) has the
potential to grease the wheels for India to enter the
space tourism market and open the avenues for
mammoth commercial opportunities.
• India’s endeavour with space tourism would have
numerous positive effects, including the creation of
employment and sizeable revenues and investments.
• However, where India is excelling at technology and
low costs, it lags behind with respect to the express
laws and legislations to govern outer space activities
including space tourism.
• Unclear status of Space tourist: No international space law has defined space tourists. Existing space treaties
such as Outer Space Treaty,
Rescue Agreement etc. are
only applicable to astronauts,
envoys of mankind, or
personnel of a spacecraft.
Since recreational space
tourists do not fall in the
realm of the treaties, they
are not rendered with these
rights and states have no
obligation to assist them.
• Authorization issues: To send
a vehicle to space, it is
compulsory for the national
and international space law
to authorize it according to
Article VI of the Outer Space
Treaty. However, the national
and international legislations
and regulations are reticent
on the subject of
authorization of space travel with tourists aboard.
• Passenger Liability: International treaties and conventions are aimed at regulating the signatory states and
are bereft of the provisions to handle the liability of private entities in space. For instance, according to
Article VII of the Montreal convention, the international liability for any damage incurred by a space object is
imposed on the launching State, regardless of the space object being a public or a private entity.
• Space insurance: It is an excruciatingly technical issue and requires expert knowledge of the launch vehicles,
satellites, and other issues. However, the current regime for space insurance provides the insurance covers
merely for the astronauts and personnel of a spacecraft and does not include any provisions of passenger
liability for space tourists.
• Environment impact: Although the carbon
dioxide emissions from space-flights are
negligible compared to other human activities
or commercial aviation, there is a potential for
longer term harm of the carbon emissions from
the spacecrafts particularly to the ozone layer.
• Ethical issues: Many health risks associated with
space flight are still not well understood, and
very little research has been done on medical
consequences of such flights on the health of
participants. National Aeronautics and Space
Administration (NASA) recommended medical
screening standards for tourist space flight participants in 2012, but these guidelines are not binding on
companies that provide launch or accommodation for space travelers.
Way ahead
• With the space tourism industry inching closer to launch every day, there emerges a dire need to formulate
laws and legislations that shall regulate issues of space tourism including the regulation of private players.
• The role of the government includes a legal responsibility to authorize and supervise private activities in
space, while ensuring that it gives the private sector enough levy to develop technologically and
commercially and enhance their growth.
For more details on Space Explorations, Space treaties for regulation of space activities and other related
issues, kindly refer to our Weekly Focus document “Space Exploration: Changing Dynamics and Pathway to the
Future”.
Page 4
76
7. SCIENCE AND TECHNOLOGY
7.1. SPACE TOURISM
Why in news?
Several private companies are developing plans to take paying customers to space on a regular basis leading to a
rapid growth in space tourism industry.
About Space Tourism
• Space tourism is space travel for recreational, leisure or business purposes. There are several different
types of space tourism, including orbital, suborbital and lunar space tourism.
o To date, orbital space tourism has been performed only by the Russian Aviation and Space Agency
known as the Roscosmos State Corporation for Space Activities or Roscosmos.
o Several private spaceflight companies are now working towards developing suborbital space tourism
vehicles to take paying customers to space (Refer infographic).
What do we call space and space travel?
• According to the Fédération Aéronautique
Internationale (world governing body for
aeronautic and astronautic records), space
starts at an altitude of 100 km (62 miles) above
the surface of the earth.
o This is the Karman line where atmospheric
lift no longer supports a flying object and
the object would need to reach orbital
velocity or risk falling back to Earth.
• Space travel is referred to as any flight
operation that takes one or more passengers
beyond the altitude of 100 km and thus into
space.
• The main difference between orbital and
suborbital flight is the speed at which a vehicle
is traveling.
o An orbital spacecraft must achieve orbital
velocity i.e. the speed that an object must
maintain to remain in orbit around a planet.
To orbit 125 miles (200 kilometers) above
Earth for instance, a spacecraft must travel
at a screaming 17,400 mph (28,000 km/h).
o Suborbital flight, in contrast, requires
much lower speeds and doesn't have the
power to achieve orbit. Instead, it will fly up
to a certain height that depends on its
speed, and then come back down once its
engines are shut off.
o At the top of their flight arc in a suborbital flight, when the object is falling back toward Earth, passengers
achieve a few minutes of weightlessness under zero gravity.
77
Key market drivers for space tourism
• The space tourism market is forecast to reach $1.3bn by 2025,
growing at a CAGR 12.4% during forecast period, 2020-2025.
Major factors accounting for the same are:
o Decline in the cost of space tourism: The total cost of a trip
into space has reduced significantly from the initial price
level of about $600 000 to $250,000 estimated to decline
further to $2000 per kilogram over coming years.
o Technological advancements: such as development of
suborbital reusable launch vehicles that is also the key to
Lowering Spaceflight Costs. Companies such as Virgin
Galactic and Blue Origin are testing suborbital flights that
can carry space tourists and researchers at altitudes
between 50 and 68 miles.
o International Interest in Space Tourism: While the bulk of
space tourism industry activities is centered in the United
States, several countries are looking to tap into the market.
o Development of space accommodations: In June 2019,
NASA announced plans to allow private citizens to fly to the
ISS with stay for short visits. Many private entities are also
developing hotels in space for tourists’ stay.
? For instance, Orion Span has announced a plan to build world’s first luxury hotel in space Aurora
Station to be built by 2021.
Issues with respect to emerging space tourism industry
Space tourism is a unique venture, and thus, the legality of activities around the proliferation of individuals in
space for recreation is yet to be formulated. The current treaties relating to space are extremely outdated and
fail to copiously deal with the legal challenges imposed by the space tourism industry. Various issues that arise
are:
78
India’s venture into space tourism
• The Indian Space Research Organization’s Gaganyan
mission (primary manned mission to space) has the
potential to grease the wheels for India to enter the
space tourism market and open the avenues for
mammoth commercial opportunities.
• India’s endeavour with space tourism would have
numerous positive effects, including the creation of
employment and sizeable revenues and investments.
• However, where India is excelling at technology and
low costs, it lags behind with respect to the express
laws and legislations to govern outer space activities
including space tourism.
• Unclear status of Space tourist: No international space law has defined space tourists. Existing space treaties
such as Outer Space Treaty,
Rescue Agreement etc. are
only applicable to astronauts,
envoys of mankind, or
personnel of a spacecraft.
Since recreational space
tourists do not fall in the
realm of the treaties, they
are not rendered with these
rights and states have no
obligation to assist them.
• Authorization issues: To send
a vehicle to space, it is
compulsory for the national
and international space law
to authorize it according to
Article VI of the Outer Space
Treaty. However, the national
and international legislations
and regulations are reticent
on the subject of
authorization of space travel with tourists aboard.
• Passenger Liability: International treaties and conventions are aimed at regulating the signatory states and
are bereft of the provisions to handle the liability of private entities in space. For instance, according to
Article VII of the Montreal convention, the international liability for any damage incurred by a space object is
imposed on the launching State, regardless of the space object being a public or a private entity.
• Space insurance: It is an excruciatingly technical issue and requires expert knowledge of the launch vehicles,
satellites, and other issues. However, the current regime for space insurance provides the insurance covers
merely for the astronauts and personnel of a spacecraft and does not include any provisions of passenger
liability for space tourists.
• Environment impact: Although the carbon
dioxide emissions from space-flights are
negligible compared to other human activities
or commercial aviation, there is a potential for
longer term harm of the carbon emissions from
the spacecrafts particularly to the ozone layer.
• Ethical issues: Many health risks associated with
space flight are still not well understood, and
very little research has been done on medical
consequences of such flights on the health of
participants. National Aeronautics and Space
Administration (NASA) recommended medical
screening standards for tourist space flight participants in 2012, but these guidelines are not binding on
companies that provide launch or accommodation for space travelers.
Way ahead
• With the space tourism industry inching closer to launch every day, there emerges a dire need to formulate
laws and legislations that shall regulate issues of space tourism including the regulation of private players.
• The role of the government includes a legal responsibility to authorize and supervise private activities in
space, while ensuring that it gives the private sector enough levy to develop technologically and
commercially and enhance their growth.
For more details on Space Explorations, Space treaties for regulation of space activities and other related
issues, kindly refer to our Weekly Focus document “Space Exploration: Changing Dynamics and Pathway to the
Future”.
79
7.2. BIOTECH-PRIDE GUIDELINES
Why in news?
“Biotech-PRIDE (Promotion
of Research and
Innovation through Data
Exchange) Guidelines”
developed by Department
of Biotechnology (DBT),
Ministry of Science and
Technology were released
recently.
About Guidelines
• Biotech-PRIDE
guidelines have been
formulated in
conformity with the
principles of NDSAP
(National Data Sharing
and Accessibility
Policy) 2012, for enabling the sharing, access and storage of
biological data.
o At present, in India the biological data is deposited in
International Repositories and there are no guidelines for
sharing it.
• Under the guidelines, it is the responsibility of the data-
generator/ producer/submitter to deposit data in an
appropriate database in the notified Data Repository.
• Data withdrawal may be granted if the individual or the
organization, whose data have been placed on a publicly
accessible database, make a justified request either directly
or through the submitter, with valid claims to the data.
• These Guidelines will be implemented through Indian
Biological Data Centre (IBDC) at Regional Center for
Biotechnology supported by Department of Biotechnology. Other datasets/ data centres will be bridged to
the IBDC which will be called Bio-Grid.
o The Bio-Grid will be a National Repository for all biological knowledge, information and data generated
through research within the country and will be responsible for:
? Enabling its exchange to facilitate the Research and Innovation,
? Developing measures for safety, standards and quality for datasets and
? Establishing detailed modalities for accessing data.
Biological data
Term biological data includes, inter alia, DNA sequence data, RNA sequence
transcriptomic data, Genotype data, Epigenomic data and protein structure data.
Characteristics of Biological Data
• It is highly complex when compared with most other applications.
• The amount and range of variability in data is high.
Benefits of sharing data
• Optimal usage of resources: Generation of data entails large amount of public
funds apart from significant time and other resources. Thus, sharing will help in
obtaining maximal benefits from investment made in generating data. It will also
prevent duplicate efforts.
• Opens new avenues for research
• Reduces unintentional errors: When preparing the data for sharing, providing
detailed documentation will eliminate guesswork, lost details, and maintain tacit
knowledge that might otherwise remain unrecorded.
• Ease in Finding: Posting data on public repositories with links to the publication
and links to data deposited ensures findability of data.
• Social Benefits: It will enable understanding of molecular and biological processes
that will contribute to areas like agriculture, animal husbandry etc.
• Data sharing is imperative to ensure transparency and reproducibility of data.
Page 5
76
7. SCIENCE AND TECHNOLOGY
7.1. SPACE TOURISM
Why in news?
Several private companies are developing plans to take paying customers to space on a regular basis leading to a
rapid growth in space tourism industry.
About Space Tourism
• Space tourism is space travel for recreational, leisure or business purposes. There are several different
types of space tourism, including orbital, suborbital and lunar space tourism.
o To date, orbital space tourism has been performed only by the Russian Aviation and Space Agency
known as the Roscosmos State Corporation for Space Activities or Roscosmos.
o Several private spaceflight companies are now working towards developing suborbital space tourism
vehicles to take paying customers to space (Refer infographic).
What do we call space and space travel?
• According to the Fédération Aéronautique
Internationale (world governing body for
aeronautic and astronautic records), space
starts at an altitude of 100 km (62 miles) above
the surface of the earth.
o This is the Karman line where atmospheric
lift no longer supports a flying object and
the object would need to reach orbital
velocity or risk falling back to Earth.
• Space travel is referred to as any flight
operation that takes one or more passengers
beyond the altitude of 100 km and thus into
space.
• The main difference between orbital and
suborbital flight is the speed at which a vehicle
is traveling.
o An orbital spacecraft must achieve orbital
velocity i.e. the speed that an object must
maintain to remain in orbit around a planet.
To orbit 125 miles (200 kilometers) above
Earth for instance, a spacecraft must travel
at a screaming 17,400 mph (28,000 km/h).
o Suborbital flight, in contrast, requires
much lower speeds and doesn't have the
power to achieve orbit. Instead, it will fly up
to a certain height that depends on its
speed, and then come back down once its
engines are shut off.
o At the top of their flight arc in a suborbital flight, when the object is falling back toward Earth, passengers
achieve a few minutes of weightlessness under zero gravity.
77
Key market drivers for space tourism
• The space tourism market is forecast to reach $1.3bn by 2025,
growing at a CAGR 12.4% during forecast period, 2020-2025.
Major factors accounting for the same are:
o Decline in the cost of space tourism: The total cost of a trip
into space has reduced significantly from the initial price
level of about $600 000 to $250,000 estimated to decline
further to $2000 per kilogram over coming years.
o Technological advancements: such as development of
suborbital reusable launch vehicles that is also the key to
Lowering Spaceflight Costs. Companies such as Virgin
Galactic and Blue Origin are testing suborbital flights that
can carry space tourists and researchers at altitudes
between 50 and 68 miles.
o International Interest in Space Tourism: While the bulk of
space tourism industry activities is centered in the United
States, several countries are looking to tap into the market.
o Development of space accommodations: In June 2019,
NASA announced plans to allow private citizens to fly to the
ISS with stay for short visits. Many private entities are also
developing hotels in space for tourists’ stay.
? For instance, Orion Span has announced a plan to build world’s first luxury hotel in space Aurora
Station to be built by 2021.
Issues with respect to emerging space tourism industry
Space tourism is a unique venture, and thus, the legality of activities around the proliferation of individuals in
space for recreation is yet to be formulated. The current treaties relating to space are extremely outdated and
fail to copiously deal with the legal challenges imposed by the space tourism industry. Various issues that arise
are:
78
India’s venture into space tourism
• The Indian Space Research Organization’s Gaganyan
mission (primary manned mission to space) has the
potential to grease the wheels for India to enter the
space tourism market and open the avenues for
mammoth commercial opportunities.
• India’s endeavour with space tourism would have
numerous positive effects, including the creation of
employment and sizeable revenues and investments.
• However, where India is excelling at technology and
low costs, it lags behind with respect to the express
laws and legislations to govern outer space activities
including space tourism.
• Unclear status of Space tourist: No international space law has defined space tourists. Existing space treaties
such as Outer Space Treaty,
Rescue Agreement etc. are
only applicable to astronauts,
envoys of mankind, or
personnel of a spacecraft.
Since recreational space
tourists do not fall in the
realm of the treaties, they
are not rendered with these
rights and states have no
obligation to assist them.
• Authorization issues: To send
a vehicle to space, it is
compulsory for the national
and international space law
to authorize it according to
Article VI of the Outer Space
Treaty. However, the national
and international legislations
and regulations are reticent
on the subject of
authorization of space travel with tourists aboard.
• Passenger Liability: International treaties and conventions are aimed at regulating the signatory states and
are bereft of the provisions to handle the liability of private entities in space. For instance, according to
Article VII of the Montreal convention, the international liability for any damage incurred by a space object is
imposed on the launching State, regardless of the space object being a public or a private entity.
• Space insurance: It is an excruciatingly technical issue and requires expert knowledge of the launch vehicles,
satellites, and other issues. However, the current regime for space insurance provides the insurance covers
merely for the astronauts and personnel of a spacecraft and does not include any provisions of passenger
liability for space tourists.
• Environment impact: Although the carbon
dioxide emissions from space-flights are
negligible compared to other human activities
or commercial aviation, there is a potential for
longer term harm of the carbon emissions from
the spacecrafts particularly to the ozone layer.
• Ethical issues: Many health risks associated with
space flight are still not well understood, and
very little research has been done on medical
consequences of such flights on the health of
participants. National Aeronautics and Space
Administration (NASA) recommended medical
screening standards for tourist space flight participants in 2012, but these guidelines are not binding on
companies that provide launch or accommodation for space travelers.
Way ahead
• With the space tourism industry inching closer to launch every day, there emerges a dire need to formulate
laws and legislations that shall regulate issues of space tourism including the regulation of private players.
• The role of the government includes a legal responsibility to authorize and supervise private activities in
space, while ensuring that it gives the private sector enough levy to develop technologically and
commercially and enhance their growth.
For more details on Space Explorations, Space treaties for regulation of space activities and other related
issues, kindly refer to our Weekly Focus document “Space Exploration: Changing Dynamics and Pathway to the
Future”.
79
7.2. BIOTECH-PRIDE GUIDELINES
Why in news?
“Biotech-PRIDE (Promotion
of Research and
Innovation through Data
Exchange) Guidelines”
developed by Department
of Biotechnology (DBT),
Ministry of Science and
Technology were released
recently.
About Guidelines
• Biotech-PRIDE
guidelines have been
formulated in
conformity with the
principles of NDSAP
(National Data Sharing
and Accessibility
Policy) 2012, for enabling the sharing, access and storage of
biological data.
o At present, in India the biological data is deposited in
International Repositories and there are no guidelines for
sharing it.
• Under the guidelines, it is the responsibility of the data-
generator/ producer/submitter to deposit data in an
appropriate database in the notified Data Repository.
• Data withdrawal may be granted if the individual or the
organization, whose data have been placed on a publicly
accessible database, make a justified request either directly
or through the submitter, with valid claims to the data.
• These Guidelines will be implemented through Indian
Biological Data Centre (IBDC) at Regional Center for
Biotechnology supported by Department of Biotechnology. Other datasets/ data centres will be bridged to
the IBDC which will be called Bio-Grid.
o The Bio-Grid will be a National Repository for all biological knowledge, information and data generated
through research within the country and will be responsible for:
? Enabling its exchange to facilitate the Research and Innovation,
? Developing measures for safety, standards and quality for datasets and
? Establishing detailed modalities for accessing data.
Biological data
Term biological data includes, inter alia, DNA sequence data, RNA sequence
transcriptomic data, Genotype data, Epigenomic data and protein structure data.
Characteristics of Biological Data
• It is highly complex when compared with most other applications.
• The amount and range of variability in data is high.
Benefits of sharing data
• Optimal usage of resources: Generation of data entails large amount of public
funds apart from significant time and other resources. Thus, sharing will help in
obtaining maximal benefits from investment made in generating data. It will also
prevent duplicate efforts.
• Opens new avenues for research
• Reduces unintentional errors: When preparing the data for sharing, providing
detailed documentation will eliminate guesswork, lost details, and maintain tacit
knowledge that might otherwise remain unrecorded.
• Ease in Finding: Posting data on public repositories with links to the publication
and links to data deposited ensures findability of data.
• Social Benefits: It will enable understanding of molecular and biological processes
that will contribute to areas like agriculture, animal husbandry etc.
• Data sharing is imperative to ensure transparency and reproducibility of data.
80
Working of Nucleic Acid Vaccines
• The modalities for data sharing shall be managed by IBDC under three categories as follows:
o Open access: Open access data are those which are intended to be shared openly by the data provider.
All data, under ‘open access’ category, generated from public-funded research will be available to
everyone (larger scientific community and public) under FAIR (findable, accessible, interoperable and
reusable) principles.
o Managed access: Managed access data are those which are shared with specific restrictions imposed by
the data producer/generator/submitter. In case of data generated using public funds, restrictions to
access and use of such data are to be established by the funding agency before its deposition.
o No access: Access to ‘sensitive data’ shall not be permitted, even if generated using public funds.
7.3. NUCLEIC ACID VACCINES
Why in News?
Recently, Zydus Cadilla, a pharmaceutical company, has approached
Drug Controller General of India for restricted emergency approval for
ZyCov-D, its plasmid DNA vaccine against COVID-19.
More on News
• If approved for use, this would be the world’s first DNA vaccine
against COVID-19.
• Both DNA and RNA are types of Nucleic acid vaccines (also known
as gene-based vaccines).
About Nucleic Acid vaccines
• Instead of injecting a weakened form of a virus or bacteria into the
body, Nucleic acid vaccines use genetic
material from a disease-causing virus or
bacterium (a pathogen) to stimulate an
immune response against it.
o That immune response, which produces
antibodies, is what protects us from
getting infected if the real virus enters
our bodies.
• Depending on the vaccine, the genetic
material could be DNA or RNA.
o DNA and RNA are the instructions our
cells use to make proteins. In our cells,
DNA is first turned into messenger RNA
(m RNA), which is then used as the
blueprint to make specific proteins.
o mRNA teaches cells how to make a
protein that triggers an immune response
inside human bodies.
• In the case of DNA vaccines, a piece of DNA
encoding the antigen is first inserted into a
bacterial plasmid.
o A plasmid is a small, often circular DNA
molecule found in bacteria and other
cells. They generally carry only a small
number of genes, notably some
associated with antibiotic resistance.
• DNA plasmids carrying the antigen are usually injected into the muscle and then driven into cells with the
help of technologies like electroporation (short pulses of electric current are used to create temporary pores
in patients’ cell membranes).
• RNA vaccines encode the antigen of interest in mRNA.
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