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Inheritance & Variation - Free MCQ Practice Test with solutions, NEET Biology


MCQ Practice Test & Solutions: Multiple Choice Questions (MCQs): Inheritance & Variation (22 Questions)

You can prepare effectively for NEET Biology Class 12 with this dedicated MCQ Practice Test (available with solutions) on the important topic of "Multiple Choice Questions (MCQs): Inheritance & Variation". These 22 questions have been designed by the experts with the latest curriculum of NEET 2026, to help you master the concept.

Test Highlights:

  • - Format: Multiple Choice Questions (MCQ)
  • - Duration: 22 minutes
  • - Number of Questions: 22

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Multiple Choice Questions (MCQs): Inheritance & Variation - Question 1

In a plant, red fruit (R) is dominant over yellow fruit (r) and tallness (T) is dominant over shortness (t). If a plant with RRTt genotype is crossed with a plant that is rrtt:

Detailed Solution: Question 1

If a plant with RRTt genotype is crossed with a plant that is rrtt 50% of the offspring will be tall with red fruit.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 2

What will be expected blood groups in the off spring when there is a cross between AB blood group mother and heterozygous B blood group father?

Detailed Solution: Question 2

AB blood group of mother have two alleles IA and IB. The heterozygous B blood group of father has alleles IB and i. The possible outcome are IA IB,IAi,IBIB and IBi. That form AB, A, B and B blood group respectively.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 3

Which of the following amino acid substitutions in the beta chain of the haemoglobin molecule leads to the development of sickle cell anaemia?

Detailed Solution: Question 3

In sickle cell anemia, glutamic acid is substituted by valine in the beta chain of hemoglobin.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 4

Two genes p and q showing 1.3% of recombination while other two genes x and y show 37.2 percent of recombination. Which pair of genes is close to each other?

Detailed Solution: Question 4

Two genes p and q showing 1.3% of recombination while other two genes x and y show 37.2 percent of recombination. p and q genes are present close to each other as they show less recombination percentage.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 5

Assertion: An organism with lethal mutation may not even develop beyond the zygote stage.

Reason: All types of gene mutations are lethal.

Detailed Solution: Question 5

An organism with lethal mutation may not even develop beyond zygote stage due to change in gene but all kinds of mutations are not lethal. Mutation is main source of variation essential for evolution.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 6

Match the following:

Column I: i. Down's syndrome; ii. Klinefelter's syndrome; iii. Turner's syndrome

Column II: a. Broad palm with characteristic palm crease; b. Gynaecomastia; c. Rudimentary ovaries; d. XO; e. XXY; f. Physical development is retarded.

1 i-c,d; ii-b,e,f; iii-a

2 i-e,c; ii-b,f; iii-a,d

3 i-a,f; ii-b,e; iii-c,d

4 i-a,c; ii-d,e; iii-b,d

Detailed Solution: Question 6

Correct answer: C.

Down's syndrome: Characteristic features include a single transverse palmar crease (broad palm) and physical development is retarded. These correspond to a and f.

Klinefelter's syndrome: The karyotype is XXY and a typical feature is gynaecomastia. These correspond to e and b.

Turner's syndrome: The karyotype is XO and individuals have rudimentary ovaries. These correspond to d and c.

Hence the correct matching is i-a,f; ii-b,e; iii-c,d, which is option C.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 7

The genes which are involved in alpha Thalassemia are---- and ----- while in beta thalassemia are----.

Detailed Solution: Question 7

Alpha Thalassemia involves genes HBA1 and HBA2 (located on chromosome 16).
Beta Thalassemia involves the HBB gene (located on chromosome 11).

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 8

A cell at the telophase stage is observed by a student in a plant brought from the field. He tells his teacher that this cell is not like other cells at the telophase stage. There is no formation of a cell plate and thus the cell is containing more chromosomes as compared to other dividing cells. This would result in:

Detailed Solution: Question 8

The absence of a cell plate indicates that cytokinesis did not occur after telophase. As a result, the nucleus retains multiple sets of chromosomes, leading to polyploidy. This condition is common in plants and results from failure of cytokinesis, not from improper segregation of chromatids.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 9

F2 generation in a Mendelian cross showed that both genotypic and phenotypic ratios are same as 1 : 2 : 1. It represents in case of

Detailed Solution: Question 9

Monohybrid cross with incomplete dominance shows both genotypic and phenotypic ratio as same (1 : 2 : 1).

Genotypic ratio - 1(AA):2(Aa):1(aa)
Phenotypic ratio - 1(Red):2(Pink):1(White)

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 10

In Mendel's experiments with garden pea, round seed shape (RR) was dominant over Wrinkled Seeds (rr), Yellow cotyledon (YY) was dominant over green cotyledon (yy). What are the expected Phenotypes in the F2 generation of the cross RRYY x rryy?

Detailed Solution: Question 10

Correct option: B

All F1 offspring from the cross are heterozygous for both traits: RrYy.

A heterozygous plant RrYy produces four kinds of gametes: RY, Ry, rY, and ry, each with probability 1/4.

When these gametes combine by selfing the F1, the two traits assort independently. Each trait alone gives a 3 : 1 phenotypic ratio (dominant : recessive) in the F2.

Combining the two independent 3 : 1 ratios gives the combined phenotypic ratio 3×3 : 3×1 : 1×3 : 1×1 = 9 : 3 : 3 : 1, which correspond to the phenotype classes:

round yellow : round green : wrinkled yellow : wrinkled green = 9 : 3 : 3 : 1.

Therefore, the F2 generation shows all four phenotypes listed in option B, in the 9 : 3 : 3 : 1 ratio.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 11

Which organism’s male contain a pair of Z chromosome as sex chromosome besides autosomes?

Detailed Solution: Question 11

In birds male contain a pair of Z chromosome as sex chromosome besides autosomes while female contain one Z and one W chromosome.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 12

Crossing over occurs at:

Detailed Solution: Question 12

Crossing over occurs at four strand stage of panchytene of meiosis-I. Each homologous chromosome has two stands. Exchange of gene occurs during this period.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 13

Deviation from Medelism’s occurs due to
a. Multiple alleles
b. Co dominance
c. Linkage and crossing over
d. Independent assortment

Detailed Solution: Question 13

Deviation from Medelism’s occurs due to co-dominance, multiple alleles, incomplete dominance in which single gene is not completely dominant over the other to produce dominant trait.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 14

Find the correct match:

Detailed Solution: Question 14

Thalassemia can be classified according to which chain of the haemoglobin molecule is affected. In α Thalassemia, production of α globin chain is affected while in β Thalassemia, production of β globin chain is affected. α Thalassemia is controlled by two closely linked genes HBA1 and HBA2 on chromosome 16 of each parent and it is observed due to mutation or deletion of one or more of the four genes. The more genes affected, the less alpha globin molecules produced. While β Thalassemia is controlled by a single gene HBB on chromosome 11 of each parent and occurs due to mutation of one or both the genes.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 15

Chromosome theory of XY sex determination was proposed by:

Detailed Solution: Question 15

Chromosome theory of XY sex determination was proposed by Wilson and Stevens.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 16

Which of the following statements are correct?

(i) Polyploidy is caused due to failure of cytokinesis after telophase.
(ii) Polyploidy results in an increase in the number of autosomes.
(iii) Turner’s syndrome is an example of polyploidy.
(iv) Polyploidy results in an increase in a whole set of chromosomes.

Detailed Solution: Question 16

Polyploidy involves an increase in a whole set of chromosomes, not just autosomes (iv).
It is indeed caused by the failure of cytokinesis, resulting in cells with multiple sets of chromosomes (i).
Turner’s syndrome is not an example of polyploidy; it is a monosomy (iii).

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 17

Which of the following would not be a feature seen in a patient with the following karyotype?

Detailed Solution: Question 17

A patient with Down’s syndrome (karyotype 47,XX,+21) might exhibit features such as many loops on fingertips, congenital heart disease, and a big and wrinkled tongue. Mucus clogging of airways is not typically associated with Down’s syndrome.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 18

Assertion: In human beings, 23 pairs of chromosomes are present in diploid cells.

Reason: 22 pairs of chromosomes are equal in male and female but a pair sex chromosome is different in them.

Detailed Solution: Question 18

In human beings, 23 pairs of chromosomes are present in diploid cells.
Twenty two pairs of chromosomes are equal in male and female but a pair sex chromosome is different in them. Male contain XY and female contain XX sex chromosome.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 19

Linkage is the_________.

Detailed Solution: Question 19

Linkage is the physical association of two genes present on same chromosome. Genes located close to each other have high linkage percentage.

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 20

Match the following:

Column I
a. Phenylketonuria
b. Down's syndrome
c. Klinefelter's syndrome
d. Turner's syndrome

Column II
i. Autosomal trisomy associated with mongolism
ii. Gynaecomastia
iii. Autosomal recessive trait associated with mental retardation
iv. Sterile females with rudimentary ovaries

Detailed Solution: Question 20

Phenylketonuria is an autosomal recessive trait associated with mental retardation (a-iii).
Down's syndrome is an autosomal trisomy associated with mongolism (b-i).
Klinefelter's syndrome is characterized by gynaecomastia (c-ii) and involves sterile males with rudimentary testes.
Turner's syndrome involves sterile females with rudimentary ovaries (d-iv).

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 21

If two pea plants having red (dominant) coloured flowers with unknown genotypes are crossed, 75% of the flowers are red and 25% are white. The genotypic constitution of the parents having red coloured flowers will be

Detailed Solution: Question 21

When two pea plants having red (dominant)c coloured flowers with unknown genotype are crossed, the 75% red and 25% white flowered plants will be produced by following the law of Mendel. This is possible only if the parents are heterozygotes. 

Multiple Choice Questions (MCQs): Inheritance & Variation - Question 22

In a given plant, red colour (R) of fruits is dominant over white fruit (r): and tallness (T) is dominant over dwarfness (t). If a plant with genotype RRTt is crossed with a plant of genotype rrtt, what will be the percentage of tall plants with red fruits in the next generation?

Detailed Solution: Question 22

According to question, tallness (T) is dominant over dwarfism (t) and red colour (R) is dominant over white (r) fruit colour.

Parent Generation; P1 : RRTt  x  rrtt

F1 generation :

Phenotypic ratio = 1  (tall plant, red fruit)         
: 1 (dwarf plant, red fruit)
; thus, percent of tall plant with red fruit is 50%.

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