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Nitrene - Organic Chemistry, Class 11 Video Lecture

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1. What is nitrene in organic chemistry?
Ans. Nitrene is a highly reactive intermediate in organic chemistry that contains a nitrogen atom with a lone pair of electrons. It has a neutral charge and is often involved in various chemical reactions, including aziridination, amination, and C-H insertion reactions.
2. How is nitrene formed?
Ans. Nitrenes can be formed through different methods, such as thermal or photochemical decomposition of azides, elimination reactions of diazonium salts, or by oxidation of amines. These processes result in the generation of a nitrogen atom with an unpaired electron, which forms the nitrene intermediate.
3. What are the properties of nitrenes?
Ans. Nitrenes are highly reactive species due to the presence of the unpaired electron. They are generally short-lived and exhibit strong tendencies to undergo reactions with suitable substrates. Nitrenes can either insert into carbon-hydrogen bonds or react with nucleophiles to form new carbon-nitrogen bonds.
4. What are the applications of nitrenes in organic synthesis?
Ans. Nitrenes play a crucial role in various synthetic transformations. They are used for the selective functionalization of carbon-hydrogen bonds, which enables the introduction of nitrogen-containing groups into organic molecules. Nitrenes are also involved in the synthesis of heterocycles, pharmaceuticals, and natural products.
5. Are nitrenes stable?
Ans. Nitrenes are generally not stable and have short lifetimes due to their high reactivity. Their reactivity can be modulated by controlling the reaction conditions and the nature of the substrates. However, the transient nature of nitrenes makes them valuable intermediates in organic chemistry as they facilitate the formation of new chemical bonds.
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