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Lead Compounds & Modification Video Lecture | CSIR NET Crash Course for Chemical Science - CSIR NET Chemical Science
FAQs on Lead Compounds & Modification Video Lecture - CSIR NET Crash Course for Chemical Science - CSIR NET Chemical Science
| 1. What are lead compounds in the context of drug development? |  |
Ans. Lead compounds are chemical compounds that show potential pharmacological activity and serve as the starting point for drug development. They are further optimized through chemical modifications to enhance their efficacy, selectivity, and safety.
| 2. How are lead compounds identified in drug discovery? | |
Ans. Lead compounds are typically identified through high-throughput screening of large compound libraries against a specific biological target. Compounds showing promising activity are selected as lead compounds for further development.
| 3. What is the significance of modifying lead compounds in drug development? | |
Ans. Modifying lead compounds through structural optimization helps in improving their pharmacokinetic properties, reducing toxicity, increasing potency, and enhancing selectivity towards the target, ultimately leading to the development of effective drugs.
| 4. What are some common strategies used for modifying lead compounds? | |
Ans. Common strategies for modifying lead compounds include structure-activity relationship studies, molecular modeling, combinatorial chemistry, fragment-based drug design, and bioisosteric replacements to optimize the compound for desired pharmacological properties.
| 5. How can lead compounds be further optimized for clinical development? | |
Ans. Lead compounds can be further optimized for clinical development by conducting preclinical studies to assess their safety and efficacy, conducting structure-activity relationship studies to refine their structure, and optimizing their pharmacokinetic properties to ensure suitable bioavailability and metabolic stability.
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Dec 23, 2024 Last updated |
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