Test: Autacoids - 2 - NEET PG MCQ

Lanreotide is a synthetic analogue of somatostatin employed in the treatment of acromegaly.

Diphenhydramine and promethazine exhibit the highest levels of anti-cholinergic activity and possess a significant capacity to traverse the blood-brain barrier, making them particularly effective for motion sickness.

This is a typical indication of vasoconstriction caused by ergot. Dihydroergotamine may be utilised for the acute treatment of migraines and can produce these effects. Given their vasoconstrictive properties, ergot alkaloids are not recommended for patients with peripheral vascular disease.

• They may also contribute to the onset of gangrene.

• Propanolol, which is the most widely prescribed medication for preventing migraine attacks.
• Timolol, atenolol, metoprolol, and nadolol may also be effective, but drugs with intrinsic sympathomimetic activity (ISA), such as pindolol, do not work.
• Calcium channel blockers, including flunarizine (which also inhibits Na⁺ channels), have proven effective.
• Methysergide, cyproheptadine, and tricyclic antidepressants (TCAs) like amitriptyline can be utilised.
• Clonidine can be administered orally for migraine prevention.
• Topiramate, an anticonvulsant, has recently been approved for migraine prophylaxis.
• Valproate and gabapentin also exhibit some prophylactic properties.

Sumatriptan is the preferred medication for treating acute severe migraines; however, it is not recommended for preventative use.

This agent acts as a mixed dilator and is an extremely effective remedy for vasospasm caused by ergot.

Additionally, it is the preferred medication for the majority of hypertensive emergencies.

The hydrogenation of ergot alkaloids reduces their vasoconstrictive effect while enhancing their α-blocking properties.

Methylergometrine (Methergin) is given during the delivery of the anterior shoulder to avert postpartum haemorrhage.

Sumatriptan reduces, while ergotamine worsens, the vomiting associated with migraines. These two medications should not be given together due to the potential risk of severe coronary spasm.

Triptans function as agonists at the 5HT_1B/1D receptors.