Medical Science Paper Optional Paper 1- 2015 | UPSC Previous Year Question Papers and Video Analysis PDF Download

 Page 1


...
v •* C -A V Z -O -N F E A
•R tfe rm -'N rR (T H R -W -l)
W i
3 T 3 S : 250
31^-Tre 3*3^1
(3rrc ^ ^ flMfcifaci ft M j t f^ n mw-fVjfo ^S)
3 7 T 3 T IT R f ^ <s««sl 3 f^TlfsTc! f f^<0 37lfaft ^ f I 
^tf^W 3PR t% 3TK ^||
TO M T 1 sfft 5 3Ttof f c fflfl ^T# 3 ^ 7 s R 3 3 ^ 7 -3 -^ ^ TO t o ! OTt % 3t K 
yr^«h ^ F R / * 7 F 1 % 3 7 3 > < f t 7 % Wf^ f^ ^ f I
T T T W T 3 icfli ^ ^Tf^ f^ J l zfa§ 3TR% TT^T-^ 3 t o ^ F H t, ^fR W ^ FT? 3^3
( ^ O ^ 0 TIo ) ^ f S R ] % - p r ^ B ^ s i t e M g ^ t o ^THT ^ T f^ T | 3 % f& c T *7T«TO % 37fcTftrfi
3 7 ^ 3 ^ 3 x R m 3 7 ^ f ^ i
^ # n , ^f?t foftRg % , w \ zppm t o ^Rf
*T?T ^ f 'f t 3 7 T 3 3 ^ ¥ R $ , 3f%cT f ^ f "3 \<3if^i^ 'g R l 3 7 ^ 3 t k 1 <^H sqi c Q f ^ l ^ ^ 1 M ^Vl f'frTT
* T 1 Wftf] |l
% 3 tT^ 7F R 1 s h H I ^ K ^ i ^ f ) I ^ ^Hdl ^ ^ t , eft "T O % ‘S tR ^>1 7F R T 3 x K 3 7 W :
T R H I ^(tactii ^ < a itrfl T 5 te T ^ 3 7 T "^ S ^ "3^% 3 7 7 1 ^t ^7 ^ 4 )1 d f ^ 1 H ( i
MEDICAL SCIENCE (PAPER-I)
Time Allowed : Three Hours Maximum Marks : 250
QUESTION PAPER SPECIFIC INSTRUCTIONS
(Please read each of the following instructions carefully before attempting questions)
There are EIGHT questions divided in two Sections and printed both in HINDI and 
in ENGLISH.
Candidate has to attempt FIVE questions in all.
Question Nos. 1 and 5 are compulsory and out of the remaining, THREE are to be attempted 
choosing at least ONE question from each Section.
The number of marks carried by a question/part is indicated against it.
Answers must be written in the medium authorized in the Admission Certificate which must 
be stated clearly on the cover of this Question-cum-Answer (QCA) Booklet in the space 
provided. No marks will be given for answers written in medium other than the authorized 
one.
Word limit in questions, wherever specified, should be adhered to.
Illustrate your answers with suitable sketches and diagrams, wherever considered necessary. 
Coloured pencils may be used for the purpose.
Attempts of questions shall be counted in sequential order. Unless struck off, attempt of a 
question shall be counted even if attempted partly. Any page or portion of the page left blank 
in the Question-cum-Answer Booklet must be clearly struck off.
36 1 { P.T.O.
Page 2


...
v •* C -A V Z -O -N F E A
•R tfe rm -'N rR (T H R -W -l)
W i
3 T 3 S : 250
31^-Tre 3*3^1
(3rrc ^ ^ flMfcifaci ft M j t f^ n mw-fVjfo ^S)
3 7 T 3 T IT R f ^ <s««sl 3 f^TlfsTc! f f^<0 37lfaft ^ f I 
^tf^W 3PR t% 3TK ^||
TO M T 1 sfft 5 3Ttof f c fflfl ^T# 3 ^ 7 s R 3 3 ^ 7 -3 -^ ^ TO t o ! OTt % 3t K 
yr^«h ^ F R / * 7 F 1 % 3 7 3 > < f t 7 % Wf^ f^ ^ f I
T T T W T 3 icfli ^ ^Tf^ f^ J l zfa§ 3TR% TT^T-^ 3 t o ^ F H t, ^fR W ^ FT? 3^3
( ^ O ^ 0 TIo ) ^ f S R ] % - p r ^ B ^ s i t e M g ^ t o ^THT ^ T f^ T | 3 % f& c T *7T«TO % 37fcTftrfi
3 7 ^ 3 ^ 3 x R m 3 7 ^ f ^ i
^ # n , ^f?t foftRg % , w \ zppm t o ^Rf
*T?T ^ f 'f t 3 7 T 3 3 ^ ¥ R $ , 3f%cT f ^ f "3 \<3if^i^ 'g R l 3 7 ^ 3 t k 1 <^H sqi c Q f ^ l ^ ^ 1 M ^Vl f'frTT
* T 1 Wftf] |l
% 3 tT^ 7F R 1 s h H I ^ K ^ i ^ f ) I ^ ^Hdl ^ ^ t , eft "T O % ‘S tR ^>1 7F R T 3 x K 3 7 W :
T R H I ^(tactii ^ < a itrfl T 5 te T ^ 3 7 T "^ S ^ "3^% 3 7 7 1 ^t ^7 ^ 4 )1 d f ^ 1 H ( i
MEDICAL SCIENCE (PAPER-I)
Time Allowed : Three Hours Maximum Marks : 250
QUESTION PAPER SPECIFIC INSTRUCTIONS
(Please read each of the following instructions carefully before attempting questions)
There are EIGHT questions divided in two Sections and printed both in HINDI and 
in ENGLISH.
Candidate has to attempt FIVE questions in all.
Question Nos. 1 and 5 are compulsory and out of the remaining, THREE are to be attempted 
choosing at least ONE question from each Section.
The number of marks carried by a question/part is indicated against it.
Answers must be written in the medium authorized in the Admission Certificate which must 
be stated clearly on the cover of this Question-cum-Answer (QCA) Booklet in the space 
provided. No marks will be given for answers written in medium other than the authorized 
one.
Word limit in questions, wherever specified, should be adhered to.
Illustrate your answers with suitable sketches and diagrams, wherever considered necessary. 
Coloured pencils may be used for the purpose.
Attempts of questions shall be counted in sequential order. Unless struck off, attempt of a 
question shall be counted even if attempted partly. Any page or portion of the page left blank 
in the Question-cum-Answer Booklet must be clearly struck off.
36 1 { P.T.O.
TgVZ—A / SECTION—A
1. ftHfcifed Wft % 3 tT C (3Tc^ # F 1 J50 ^ 3) :
Answer all of the following (in about 150 words each) : 10>«5=50
(a) ftHfafeid 3 T R T C T C :
Describe stomach under the following headings : 1+4+3+2=10
(i)
Location
(a) ?\m
External features
(Hi) BVRq
Arterial supply
(iv) T«RT
Clinical anatomy
(b) c ite -M -W T % ctto 3 T T tn % ^TT3tf 3 T ^ ^TT^I
Give the sequence of events that occurs during transmission of nerve impulse 
through neuromuscular junction. 10
Differentiate between isometric and isotonic contraction in skeletal muscle.
Give one example of each type. 8+2=10
(d) % fR H F 1 ^ tf^ l
Describe the cervical part of the sympathetic chain. 10
(e) ^ % irci
(^fto TT ^o 3TRo) ^ f ? "F T E 1 % ^fto T K f? o 3 T R O % STT^cH %
1 1 i-^\o TTt^o 3TRO w ^
Define ‘clearance’ of a substance by kidneys. Which clearance tests provide an 
estimate of glomerular filtration rate (GFR)? Explain which of these is the test 
of choice for assessment of GFR. What is eGFR? 2+3+3+2=10
2. (a) ttaf*R B6) % w l ^JT ?? TO
What are the main important functions of pyridoxine (vitamin B6)? Explain. 20
(b) 3?K "TTrf^rf T rfrR ^ n % I? ^1 |?
What are the features of innate and acquired immunity? What is the 
mechanism of action of immunoglobulins? 10+5=15
(c) S W ftc l< *b % ^ c T ^ ^ ft < f7 i ^ | f^ T 7 |
Describe the projection fibres of cerebrum. 15
€~nV Z-® -& $m /36 2
Page 3


...
v •* C -A V Z -O -N F E A
•R tfe rm -'N rR (T H R -W -l)
W i
3 T 3 S : 250
31^-Tre 3*3^1
(3rrc ^ ^ flMfcifaci ft M j t f^ n mw-fVjfo ^S)
3 7 T 3 T IT R f ^ <s««sl 3 f^TlfsTc! f f^<0 37lfaft ^ f I 
^tf^W 3PR t% 3TK ^||
TO M T 1 sfft 5 3Ttof f c fflfl ^T# 3 ^ 7 s R 3 3 ^ 7 -3 -^ ^ TO t o ! OTt % 3t K 
yr^«h ^ F R / * 7 F 1 % 3 7 3 > < f t 7 % Wf^ f^ ^ f I
T T T W T 3 icfli ^ ^Tf^ f^ J l zfa§ 3TR% TT^T-^ 3 t o ^ F H t, ^fR W ^ FT? 3^3
( ^ O ^ 0 TIo ) ^ f S R ] % - p r ^ B ^ s i t e M g ^ t o ^THT ^ T f^ T | 3 % f& c T *7T«TO % 37fcTftrfi
3 7 ^ 3 ^ 3 x R m 3 7 ^ f ^ i
^ # n , ^f?t foftRg % , w \ zppm t o ^Rf
*T?T ^ f 'f t 3 7 T 3 3 ^ ¥ R $ , 3f%cT f ^ f "3 \<3if^i^ 'g R l 3 7 ^ 3 t k 1 <^H sqi c Q f ^ l ^ ^ 1 M ^Vl f'frTT
* T 1 Wftf] |l
% 3 tT^ 7F R 1 s h H I ^ K ^ i ^ f ) I ^ ^Hdl ^ ^ t , eft "T O % ‘S tR ^>1 7F R T 3 x K 3 7 W :
T R H I ^(tactii ^ < a itrfl T 5 te T ^ 3 7 T "^ S ^ "3^% 3 7 7 1 ^t ^7 ^ 4 )1 d f ^ 1 H ( i
MEDICAL SCIENCE (PAPER-I)
Time Allowed : Three Hours Maximum Marks : 250
QUESTION PAPER SPECIFIC INSTRUCTIONS
(Please read each of the following instructions carefully before attempting questions)
There are EIGHT questions divided in two Sections and printed both in HINDI and 
in ENGLISH.
Candidate has to attempt FIVE questions in all.
Question Nos. 1 and 5 are compulsory and out of the remaining, THREE are to be attempted 
choosing at least ONE question from each Section.
The number of marks carried by a question/part is indicated against it.
Answers must be written in the medium authorized in the Admission Certificate which must 
be stated clearly on the cover of this Question-cum-Answer (QCA) Booklet in the space 
provided. No marks will be given for answers written in medium other than the authorized 
one.
Word limit in questions, wherever specified, should be adhered to.
Illustrate your answers with suitable sketches and diagrams, wherever considered necessary. 
Coloured pencils may be used for the purpose.
Attempts of questions shall be counted in sequential order. Unless struck off, attempt of a 
question shall be counted even if attempted partly. Any page or portion of the page left blank 
in the Question-cum-Answer Booklet must be clearly struck off.
36 1 { P.T.O.
TgVZ—A / SECTION—A
1. ftHfcifed Wft % 3 tT C (3Tc^ # F 1 J50 ^ 3) :
Answer all of the following (in about 150 words each) : 10>«5=50
(a) ftHfafeid 3 T R T C T C :
Describe stomach under the following headings : 1+4+3+2=10
(i)
Location
(a) ?\m
External features
(Hi) BVRq
Arterial supply
(iv) T«RT
Clinical anatomy
(b) c ite -M -W T % ctto 3 T T tn % ^TT3tf 3 T ^ ^TT^I
Give the sequence of events that occurs during transmission of nerve impulse 
through neuromuscular junction. 10
Differentiate between isometric and isotonic contraction in skeletal muscle.
Give one example of each type. 8+2=10
(d) % fR H F 1 ^ tf^ l
Describe the cervical part of the sympathetic chain. 10
(e) ^ % irci
(^fto TT ^o 3TRo) ^ f ? "F T E 1 % ^fto T K f? o 3 T R O % STT^cH %
1 1 i-^\o TTt^o 3TRO w ^
Define ‘clearance’ of a substance by kidneys. Which clearance tests provide an 
estimate of glomerular filtration rate (GFR)? Explain which of these is the test 
of choice for assessment of GFR. What is eGFR? 2+3+3+2=10
2. (a) ttaf*R B6) % w l ^JT ?? TO
What are the main important functions of pyridoxine (vitamin B6)? Explain. 20
(b) 3?K "TTrf^rf T rfrR ^ n % I? ^1 |?
What are the features of innate and acquired immunity? What is the 
mechanism of action of immunoglobulins? 10+5=15
(c) S W ftc l< *b % ^ c T ^ ^ ft < f7 i ^ | f^ T 7 |
Describe the projection fibres of cerebrum. 15
€~nV Z-® -& $m /36 2
3. (a) 3fR
Define ‘cardiac output’ and ‘cardiac index'. Describe the regulation of cardiac 
output in the body. 5+15=20
(b) fW t <rta % 3?K -ton % ^
Describe in detail about the origin and distribution of the sciatic nerve. Add a 
note on its clinical importance. 12+3=15
(c) ^ :
Discuss briefly : 5X3=15
(i) fadiftn D 3 rfrrd ^ fr
Vitamin D resistant rickets
(ii) (|h) TO %
Chromium as a trace element
(Hi) - Z T fK T
Role of plasma enzymes in evaluation of liver function
4. (a) ftnfaRsM ^ :
Describe tongue under the following subheadings : 20
(i) 3 ^ citol 3TT^
Mucous membrane and its nerve supply
(ii) sin ^ i "g n n ^ ^ icrfi T T fc n s r f ciR = h i
Muscles, movements produced by them and their nerve supply
(iii) vftftoR 
Lymphatic drainage
(iv)
Clinical anatomy
(b) *cR % W W R 3 # j l % ^cTT^I ZQ
Name the hormones involved in the regulation of blood glucose level. Discuss 
the pathophysiology of diabetes mellitus. 5+10=15
(c) q F t ftrim sfa ^ ^rf^i
Enumerate the hormones of posterior pituitary gland and describe their 
actions in the body. 15
£-^2-©-3$Jf<££l/36 3 [ P.T.O.
Page 4


...
v •* C -A V Z -O -N F E A
•R tfe rm -'N rR (T H R -W -l)
W i
3 T 3 S : 250
31^-Tre 3*3^1
(3rrc ^ ^ flMfcifaci ft M j t f^ n mw-fVjfo ^S)
3 7 T 3 T IT R f ^ <s««sl 3 f^TlfsTc! f f^<0 37lfaft ^ f I 
^tf^W 3PR t% 3TK ^||
TO M T 1 sfft 5 3Ttof f c fflfl ^T# 3 ^ 7 s R 3 3 ^ 7 -3 -^ ^ TO t o ! OTt % 3t K 
yr^«h ^ F R / * 7 F 1 % 3 7 3 > < f t 7 % Wf^ f^ ^ f I
T T T W T 3 icfli ^ ^Tf^ f^ J l zfa§ 3TR% TT^T-^ 3 t o ^ F H t, ^fR W ^ FT? 3^3
( ^ O ^ 0 TIo ) ^ f S R ] % - p r ^ B ^ s i t e M g ^ t o ^THT ^ T f^ T | 3 % f& c T *7T«TO % 37fcTftrfi
3 7 ^ 3 ^ 3 x R m 3 7 ^ f ^ i
^ # n , ^f?t foftRg % , w \ zppm t o ^Rf
*T?T ^ f 'f t 3 7 T 3 3 ^ ¥ R $ , 3f%cT f ^ f "3 \<3if^i^ 'g R l 3 7 ^ 3 t k 1 <^H sqi c Q f ^ l ^ ^ 1 M ^Vl f'frTT
* T 1 Wftf] |l
% 3 tT^ 7F R 1 s h H I ^ K ^ i ^ f ) I ^ ^Hdl ^ ^ t , eft "T O % ‘S tR ^>1 7F R T 3 x K 3 7 W :
T R H I ^(tactii ^ < a itrfl T 5 te T ^ 3 7 T "^ S ^ "3^% 3 7 7 1 ^t ^7 ^ 4 )1 d f ^ 1 H ( i
MEDICAL SCIENCE (PAPER-I)
Time Allowed : Three Hours Maximum Marks : 250
QUESTION PAPER SPECIFIC INSTRUCTIONS
(Please read each of the following instructions carefully before attempting questions)
There are EIGHT questions divided in two Sections and printed both in HINDI and 
in ENGLISH.
Candidate has to attempt FIVE questions in all.
Question Nos. 1 and 5 are compulsory and out of the remaining, THREE are to be attempted 
choosing at least ONE question from each Section.
The number of marks carried by a question/part is indicated against it.
Answers must be written in the medium authorized in the Admission Certificate which must 
be stated clearly on the cover of this Question-cum-Answer (QCA) Booklet in the space 
provided. No marks will be given for answers written in medium other than the authorized 
one.
Word limit in questions, wherever specified, should be adhered to.
Illustrate your answers with suitable sketches and diagrams, wherever considered necessary. 
Coloured pencils may be used for the purpose.
Attempts of questions shall be counted in sequential order. Unless struck off, attempt of a 
question shall be counted even if attempted partly. Any page or portion of the page left blank 
in the Question-cum-Answer Booklet must be clearly struck off.
36 1 { P.T.O.
TgVZ—A / SECTION—A
1. ftHfcifed Wft % 3 tT C (3Tc^ # F 1 J50 ^ 3) :
Answer all of the following (in about 150 words each) : 10>«5=50
(a) ftHfafeid 3 T R T C T C :
Describe stomach under the following headings : 1+4+3+2=10
(i)
Location
(a) ?\m
External features
(Hi) BVRq
Arterial supply
(iv) T«RT
Clinical anatomy
(b) c ite -M -W T % ctto 3 T T tn % ^TT3tf 3 T ^ ^TT^I
Give the sequence of events that occurs during transmission of nerve impulse 
through neuromuscular junction. 10
Differentiate between isometric and isotonic contraction in skeletal muscle.
Give one example of each type. 8+2=10
(d) % fR H F 1 ^ tf^ l
Describe the cervical part of the sympathetic chain. 10
(e) ^ % irci
(^fto TT ^o 3TRo) ^ f ? "F T E 1 % ^fto T K f? o 3 T R O % STT^cH %
1 1 i-^\o TTt^o 3TRO w ^
Define ‘clearance’ of a substance by kidneys. Which clearance tests provide an 
estimate of glomerular filtration rate (GFR)? Explain which of these is the test 
of choice for assessment of GFR. What is eGFR? 2+3+3+2=10
2. (a) ttaf*R B6) % w l ^JT ?? TO
What are the main important functions of pyridoxine (vitamin B6)? Explain. 20
(b) 3?K "TTrf^rf T rfrR ^ n % I? ^1 |?
What are the features of innate and acquired immunity? What is the 
mechanism of action of immunoglobulins? 10+5=15
(c) S W ftc l< *b % ^ c T ^ ^ ft < f7 i ^ | f^ T 7 |
Describe the projection fibres of cerebrum. 15
€~nV Z-® -& $m /36 2
3. (a) 3fR
Define ‘cardiac output’ and ‘cardiac index'. Describe the regulation of cardiac 
output in the body. 5+15=20
(b) fW t <rta % 3?K -ton % ^
Describe in detail about the origin and distribution of the sciatic nerve. Add a 
note on its clinical importance. 12+3=15
(c) ^ :
Discuss briefly : 5X3=15
(i) fadiftn D 3 rfrrd ^ fr
Vitamin D resistant rickets
(ii) (|h) TO %
Chromium as a trace element
(Hi) - Z T fK T
Role of plasma enzymes in evaluation of liver function
4. (a) ftnfaRsM ^ :
Describe tongue under the following subheadings : 20
(i) 3 ^ citol 3TT^
Mucous membrane and its nerve supply
(ii) sin ^ i "g n n ^ ^ icrfi T T fc n s r f ciR = h i
Muscles, movements produced by them and their nerve supply
(iii) vftftoR 
Lymphatic drainage
(iv)
Clinical anatomy
(b) *cR % W W R 3 # j l % ^cTT^I ZQ
Name the hormones involved in the regulation of blood glucose level. Discuss 
the pathophysiology of diabetes mellitus. 5+10=15
(c) q F t ftrim sfa ^ ^rf^i
Enumerate the hormones of posterior pituitary gland and describe their 
actions in the body. 15
£-^2-©-3$Jf<££l/36 3 [ P.T.O.
/ SECTION—B
5. PlHfdfed wft TO! % 3rR ( 3 ^ BWT J50 ?T^t 3) :
Answer all of the following (in about 150 words each) : 10x5=50
(a) ^ % TTCMte VVWft ^ f^FTT^I % ^ rf^ fr ^ ^cTT^I
Enumerate the chemical mediators of acute inflammation. Give their 
mechanisms of action. 3+7=10
(b) 3#infen epfff*r wm i srfcBnfen
Define and classify hypersensitivity. Describe type I hypersensitivity. 10
(c) W s 1 W S Z % cte S T T ^ c p J I % cfRR %
Discuss the pharmacotherapy of gout. Describe the rationale of the use of 
colchicine during acute attack of gout. 10
(d) V f| % % t o ?rt^ i %
3^ ^ ^TT^I
Enumerate the major etiological factors associated with carcinoma of lung.
Give the gross, microscopic features and spread of squamous cell carcinoma 
lung. 3+7=10
( e) 2 5 - ^ f f a ^ s J lc fi % ^ i f ^ f *T F T ^ f W l - ^ \ « j ^ j ^ w f t f I m
3TN t M\ xftft M)R Wftcf
A young person of 25 years has sustained smooth barrel shotgun firearm 
injury on right side of chest. How will you establish on clinical examination the 
entry wound and distance of fire? 10
6. (a) ~^m\ % f^H %
¦ s n ^ r I? Twfawjfrn ^ ^ ^ Wm,\
Give etiopathogenesis of carcinoma cervix. What are the tests employed for 
diagnosis of carcinoma cervix? Give the stages of carcinoma cervix., 9+6+5=20
(b) % f^m ^rf^T tR ^ f i % t o *fteT ftercS ^ %
TO1 ! 1*RT^|
Discuss the pharmacology of calcium channel blockers. Enumerate the 
reasons for combining beta blockers with amlodipine. 15
(c) ^ ( A M ) 4K m ^ S R f
3TferfxMt 3fR M t a l f^ R ^ P T ^ R |
Discuss morphology and antigenic types of dengue virus. Describe the clinical 
manifestations and laboratory diagnosis of dengue fever. 15
7. (a) ^ ^ sjfrP tS T c ft ^ c T C ^ 3 3R* cl^ ^
Write hypothetical medicolegal report of an injured person having sustained 
stab wound penetrating lung deep on right side of chest. 20
/ 36 4
Page 5


...
v •* C -A V Z -O -N F E A
•R tfe rm -'N rR (T H R -W -l)
W i
3 T 3 S : 250
31^-Tre 3*3^1
(3rrc ^ ^ flMfcifaci ft M j t f^ n mw-fVjfo ^S)
3 7 T 3 T IT R f ^ <s««sl 3 f^TlfsTc! f f^<0 37lfaft ^ f I 
^tf^W 3PR t% 3TK ^||
TO M T 1 sfft 5 3Ttof f c fflfl ^T# 3 ^ 7 s R 3 3 ^ 7 -3 -^ ^ TO t o ! OTt % 3t K 
yr^«h ^ F R / * 7 F 1 % 3 7 3 > < f t 7 % Wf^ f^ ^ f I
T T T W T 3 icfli ^ ^Tf^ f^ J l zfa§ 3TR% TT^T-^ 3 t o ^ F H t, ^fR W ^ FT? 3^3
( ^ O ^ 0 TIo ) ^ f S R ] % - p r ^ B ^ s i t e M g ^ t o ^THT ^ T f^ T | 3 % f& c T *7T«TO % 37fcTftrfi
3 7 ^ 3 ^ 3 x R m 3 7 ^ f ^ i
^ # n , ^f?t foftRg % , w \ zppm t o ^Rf
*T?T ^ f 'f t 3 7 T 3 3 ^ ¥ R $ , 3f%cT f ^ f "3 \<3if^i^ 'g R l 3 7 ^ 3 t k 1 <^H sqi c Q f ^ l ^ ^ 1 M ^Vl f'frTT
* T 1 Wftf] |l
% 3 tT^ 7F R 1 s h H I ^ K ^ i ^ f ) I ^ ^Hdl ^ ^ t , eft "T O % ‘S tR ^>1 7F R T 3 x K 3 7 W :
T R H I ^(tactii ^ < a itrfl T 5 te T ^ 3 7 T "^ S ^ "3^% 3 7 7 1 ^t ^7 ^ 4 )1 d f ^ 1 H ( i
MEDICAL SCIENCE (PAPER-I)
Time Allowed : Three Hours Maximum Marks : 250
QUESTION PAPER SPECIFIC INSTRUCTIONS
(Please read each of the following instructions carefully before attempting questions)
There are EIGHT questions divided in two Sections and printed both in HINDI and 
in ENGLISH.
Candidate has to attempt FIVE questions in all.
Question Nos. 1 and 5 are compulsory and out of the remaining, THREE are to be attempted 
choosing at least ONE question from each Section.
The number of marks carried by a question/part is indicated against it.
Answers must be written in the medium authorized in the Admission Certificate which must 
be stated clearly on the cover of this Question-cum-Answer (QCA) Booklet in the space 
provided. No marks will be given for answers written in medium other than the authorized 
one.
Word limit in questions, wherever specified, should be adhered to.
Illustrate your answers with suitable sketches and diagrams, wherever considered necessary. 
Coloured pencils may be used for the purpose.
Attempts of questions shall be counted in sequential order. Unless struck off, attempt of a 
question shall be counted even if attempted partly. Any page or portion of the page left blank 
in the Question-cum-Answer Booklet must be clearly struck off.
36 1 { P.T.O.
TgVZ—A / SECTION—A
1. ftHfcifed Wft % 3 tT C (3Tc^ # F 1 J50 ^ 3) :
Answer all of the following (in about 150 words each) : 10>«5=50
(a) ftHfafeid 3 T R T C T C :
Describe stomach under the following headings : 1+4+3+2=10
(i)
Location
(a) ?\m
External features
(Hi) BVRq
Arterial supply
(iv) T«RT
Clinical anatomy
(b) c ite -M -W T % ctto 3 T T tn % ^TT3tf 3 T ^ ^TT^I
Give the sequence of events that occurs during transmission of nerve impulse 
through neuromuscular junction. 10
Differentiate between isometric and isotonic contraction in skeletal muscle.
Give one example of each type. 8+2=10
(d) % fR H F 1 ^ tf^ l
Describe the cervical part of the sympathetic chain. 10
(e) ^ % irci
(^fto TT ^o 3TRo) ^ f ? "F T E 1 % ^fto T K f? o 3 T R O % STT^cH %
1 1 i-^\o TTt^o 3TRO w ^
Define ‘clearance’ of a substance by kidneys. Which clearance tests provide an 
estimate of glomerular filtration rate (GFR)? Explain which of these is the test 
of choice for assessment of GFR. What is eGFR? 2+3+3+2=10
2. (a) ttaf*R B6) % w l ^JT ?? TO
What are the main important functions of pyridoxine (vitamin B6)? Explain. 20
(b) 3?K "TTrf^rf T rfrR ^ n % I? ^1 |?
What are the features of innate and acquired immunity? What is the 
mechanism of action of immunoglobulins? 10+5=15
(c) S W ftc l< *b % ^ c T ^ ^ ft < f7 i ^ | f^ T 7 |
Describe the projection fibres of cerebrum. 15
€~nV Z-® -& $m /36 2
3. (a) 3fR
Define ‘cardiac output’ and ‘cardiac index'. Describe the regulation of cardiac 
output in the body. 5+15=20
(b) fW t <rta % 3?K -ton % ^
Describe in detail about the origin and distribution of the sciatic nerve. Add a 
note on its clinical importance. 12+3=15
(c) ^ :
Discuss briefly : 5X3=15
(i) fadiftn D 3 rfrrd ^ fr
Vitamin D resistant rickets
(ii) (|h) TO %
Chromium as a trace element
(Hi) - Z T fK T
Role of plasma enzymes in evaluation of liver function
4. (a) ftnfaRsM ^ :
Describe tongue under the following subheadings : 20
(i) 3 ^ citol 3TT^
Mucous membrane and its nerve supply
(ii) sin ^ i "g n n ^ ^ icrfi T T fc n s r f ciR = h i
Muscles, movements produced by them and their nerve supply
(iii) vftftoR 
Lymphatic drainage
(iv)
Clinical anatomy
(b) *cR % W W R 3 # j l % ^cTT^I ZQ
Name the hormones involved in the regulation of blood glucose level. Discuss 
the pathophysiology of diabetes mellitus. 5+10=15
(c) q F t ftrim sfa ^ ^rf^i
Enumerate the hormones of posterior pituitary gland and describe their 
actions in the body. 15
£-^2-©-3$Jf<££l/36 3 [ P.T.O.
/ SECTION—B
5. PlHfdfed wft TO! % 3rR ( 3 ^ BWT J50 ?T^t 3) :
Answer all of the following (in about 150 words each) : 10x5=50
(a) ^ % TTCMte VVWft ^ f^FTT^I % ^ rf^ fr ^ ^cTT^I
Enumerate the chemical mediators of acute inflammation. Give their 
mechanisms of action. 3+7=10
(b) 3#infen epfff*r wm i srfcBnfen
Define and classify hypersensitivity. Describe type I hypersensitivity. 10
(c) W s 1 W S Z % cte S T T ^ c p J I % cfRR %
Discuss the pharmacotherapy of gout. Describe the rationale of the use of 
colchicine during acute attack of gout. 10
(d) V f| % % t o ?rt^ i %
3^ ^ ^TT^I
Enumerate the major etiological factors associated with carcinoma of lung.
Give the gross, microscopic features and spread of squamous cell carcinoma 
lung. 3+7=10
( e) 2 5 - ^ f f a ^ s J lc fi % ^ i f ^ f *T F T ^ f W l - ^ \ « j ^ j ^ w f t f I m
3TN t M\ xftft M)R Wftcf
A young person of 25 years has sustained smooth barrel shotgun firearm 
injury on right side of chest. How will you establish on clinical examination the 
entry wound and distance of fire? 10
6. (a) ~^m\ % f^H %
¦ s n ^ r I? Twfawjfrn ^ ^ ^ Wm,\
Give etiopathogenesis of carcinoma cervix. What are the tests employed for 
diagnosis of carcinoma cervix? Give the stages of carcinoma cervix., 9+6+5=20
(b) % f^m ^rf^T tR ^ f i % t o *fteT ftercS ^ %
TO1 ! 1*RT^|
Discuss the pharmacology of calcium channel blockers. Enumerate the 
reasons for combining beta blockers with amlodipine. 15
(c) ^ ( A M ) 4K m ^ S R f
3TferfxMt 3fR M t a l f^ R ^ P T ^ R |
Discuss morphology and antigenic types of dengue virus. Describe the clinical 
manifestations and laboratory diagnosis of dengue fever. 15
7. (a) ^ ^ sjfrP tS T c ft ^ c T C ^ 3 3R* cl^ ^
Write hypothetical medicolegal report of an injured person having sustained 
stab wound penetrating lung deep on right side of chest. 20
/ 36 4
(b) ^ ^ f?W I f I TOT f^ iq iT tiC ll % 3?R MtR ^ iT 3u 1 h
^ R t
A young female has consumed aluminium phosphide. Describe the symptoms, 
signs and management of such poisoning. 15
(c) W ^ :
Explain why : 5><3=15
(i) J^HI^ ^ fcn ^ T R T
Frusemide should not be co-administered with aminoglycoside antibiotics
(ii) % ^TR 3 W?m X&HW t o ^ T c T I f
Sulfadoxine and pyrimethamine combination is used in the treatment of 
malaria
(Hi) w m I
Propranolol is contraindicated in chronic obstructive pulmonary disease
8. (a) RnfefRsId M M :
Write short notes on the following : 10><2=20
(i) fitmf&n rterfmi ^ ^sf, ttwrrm 3*k t e r
Morphology, life cycle, pathogenicity and laboratory diagnosis of Giardia 
lamblia 10
(ii) ##37 XtWR 3 ?K
Pathogenesis and laboratory diagnosis of Candida albicans 10
(b) ^ ^ “ STfd ^ fifM wn f?
^ c T T ^ t
What are the major and minor criteria of rheumatic fever? Give the pathology 
and sequelae of rheumatic carditis. 15
(c) ftHRifed ^ t o % tr ^ ^ ifrfor :
Discuss briefly the mechanism of action, uses and side effects of the following :
5x3=15
(i)
dVdlfirlf^H
Sitagliptin
(n)
Clonidine
(H i)
&
o
&
0
1 INH
? ? ?
C-&VZ-©-&$<£®/36 5 SB6—570