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A. NAtural Selection 
? Charles Darwin 
? British naturalist who sailed the world 
? Developed theory of evolution based on natural selection after studying animals on 
Galapagos Islands 
? Observed that there were similar animals on isolated animals, but they each had slight 
variations (ex. Beak shape, neck length, etc.) 
¦ There must have originally been a variety of beak lengths, but only the longest 
ones could survive. Since those with the longest beaks could reproduce better, 
they were more likely to contribute offspring with the same traits to the next 
generation 
? The Origin of Species 
¦ Variation exists in the population and some of this variation is heritable 
¦ Populations tend to make lots of offspring 
¦ Resources are limited, thus a struggle ensues 
¦ Those with better traits (phenotypes) will do a better job getting those resources 
and reproduce more 
¦ The genes that code for “better” traits in the current environment start increasing 
in the population 
? The earth is always changing what what may be good now may not be in 
the future; evolution will always be occurring 
? “Survival of the fittest” 
? Jean-Baptiste Lamarck 
? Widely accepted theory of evolution in Darwin’s 
? Acquired traits inherited and passed onto offspring 
¦ “Law of use and disuse” 
¦ According to Lamarck, giraffes have long necks because they constantly use 
them 
? WRONG 
¦ Changes in somatic cells do not change gametes and thus cannot be passed onto 
offspring 
? Evidence for Evolution 
? Paleontology 
¦ Study of fossils 
¦ Revealed great variety of organisms and the major lines of evolution 
¦ Tend to form in sedimentary rock 
? Biogeography 
¦ Study of the distribution of flora and fauna in the environment 
¦ Related species found in widely separated regions of the world 
¦ Suggests a common ancestor between species 
¦ Ex: pangea 
? Embryology 
 
Page 2


    
A. NAtural Selection 
? Charles Darwin 
? British naturalist who sailed the world 
? Developed theory of evolution based on natural selection after studying animals on 
Galapagos Islands 
? Observed that there were similar animals on isolated animals, but they each had slight 
variations (ex. Beak shape, neck length, etc.) 
¦ There must have originally been a variety of beak lengths, but only the longest 
ones could survive. Since those with the longest beaks could reproduce better, 
they were more likely to contribute offspring with the same traits to the next 
generation 
? The Origin of Species 
¦ Variation exists in the population and some of this variation is heritable 
¦ Populations tend to make lots of offspring 
¦ Resources are limited, thus a struggle ensues 
¦ Those with better traits (phenotypes) will do a better job getting those resources 
and reproduce more 
¦ The genes that code for “better” traits in the current environment start increasing 
in the population 
? The earth is always changing what what may be good now may not be in 
the future; evolution will always be occurring 
? “Survival of the fittest” 
? Jean-Baptiste Lamarck 
? Widely accepted theory of evolution in Darwin’s 
? Acquired traits inherited and passed onto offspring 
¦ “Law of use and disuse” 
¦ According to Lamarck, giraffes have long necks because they constantly use 
them 
? WRONG 
¦ Changes in somatic cells do not change gametes and thus cannot be passed onto 
offspring 
? Evidence for Evolution 
? Paleontology 
¦ Study of fossils 
¦ Revealed great variety of organisms and the major lines of evolution 
¦ Tend to form in sedimentary rock 
? Biogeography 
¦ Study of the distribution of flora and fauna in the environment 
¦ Related species found in widely separated regions of the world 
¦ Suggests a common ancestor between species 
¦ Ex: pangea 
? Embryology 
 
¦ Study of the development of an organism 
¦ Early stages of vertebrate development all look alike 
? All vertebrates show fishlike “gill slits” 
? Comparative anatomy 
¦ Study of anatomy of various animals 
¦ Vestigial Strucutres 
? Structures with little-no function 
? Remannts of structures that served important functions in the organism’s 
ancestors 
¦ Homologous structures 
? Similar structures that serve different functions 
¦ Analogous structures 
? Same function different structure 
 
? Molecular biology 
¦ Most compelling proof of evolution 
¦ Examining nucleotide/amino acid sequences of different organisms 
¦ Common genes and proteins 
¦ Ex: Hox Genes (body paint controller genes) 
¦ Shared structures help us to understand not only how structures develop but also 
supports shared shared ancestry 
? Artificial Selection 
¦ Humans selecting which organisms reproduce and survive so the future 
generations have traits that humans have selected 
¦ Ex. dog breeds 
B. Common Ancestry 
? Phylogenetic trees 
? Aka cladogram 
? Study the relationships between organisms 
? Begin with common ancestor and then branch out 
? Anytime there is a fork in the road, it is called a common ancestor node 
 
Page 3


    
A. NAtural Selection 
? Charles Darwin 
? British naturalist who sailed the world 
? Developed theory of evolution based on natural selection after studying animals on 
Galapagos Islands 
? Observed that there were similar animals on isolated animals, but they each had slight 
variations (ex. Beak shape, neck length, etc.) 
¦ There must have originally been a variety of beak lengths, but only the longest 
ones could survive. Since those with the longest beaks could reproduce better, 
they were more likely to contribute offspring with the same traits to the next 
generation 
? The Origin of Species 
¦ Variation exists in the population and some of this variation is heritable 
¦ Populations tend to make lots of offspring 
¦ Resources are limited, thus a struggle ensues 
¦ Those with better traits (phenotypes) will do a better job getting those resources 
and reproduce more 
¦ The genes that code for “better” traits in the current environment start increasing 
in the population 
? The earth is always changing what what may be good now may not be in 
the future; evolution will always be occurring 
? “Survival of the fittest” 
? Jean-Baptiste Lamarck 
? Widely accepted theory of evolution in Darwin’s 
? Acquired traits inherited and passed onto offspring 
¦ “Law of use and disuse” 
¦ According to Lamarck, giraffes have long necks because they constantly use 
them 
? WRONG 
¦ Changes in somatic cells do not change gametes and thus cannot be passed onto 
offspring 
? Evidence for Evolution 
? Paleontology 
¦ Study of fossils 
¦ Revealed great variety of organisms and the major lines of evolution 
¦ Tend to form in sedimentary rock 
? Biogeography 
¦ Study of the distribution of flora and fauna in the environment 
¦ Related species found in widely separated regions of the world 
¦ Suggests a common ancestor between species 
¦ Ex: pangea 
? Embryology 
 
¦ Study of the development of an organism 
¦ Early stages of vertebrate development all look alike 
? All vertebrates show fishlike “gill slits” 
? Comparative anatomy 
¦ Study of anatomy of various animals 
¦ Vestigial Strucutres 
? Structures with little-no function 
? Remannts of structures that served important functions in the organism’s 
ancestors 
¦ Homologous structures 
? Similar structures that serve different functions 
¦ Analogous structures 
? Same function different structure 
 
? Molecular biology 
¦ Most compelling proof of evolution 
¦ Examining nucleotide/amino acid sequences of different organisms 
¦ Common genes and proteins 
¦ Ex: Hox Genes (body paint controller genes) 
¦ Shared structures help us to understand not only how structures develop but also 
supports shared shared ancestry 
? Artificial Selection 
¦ Humans selecting which organisms reproduce and survive so the future 
generations have traits that humans have selected 
¦ Ex. dog breeds 
B. Common Ancestry 
? Phylogenetic trees 
? Aka cladogram 
? Study the relationships between organisms 
? Begin with common ancestor and then branch out 
? Anytime there is a fork in the road, it is called a common ancestor node 
 
¦ Common ancestors likely do not exist anymore, but they are the point at which 
evolution went in two directions 
? Outgroup 
¦ Related to ingroup but diverged before others 
¦ Serves as reference group 
¦ Always stems from foot of tree 
? Monophyletic=ancestral species+all descendants 
? PAraphyletic=ancestral species+some descendants 
? Polyphyletic=ancestral species+descendants+distantly related organism 
? Taxonomic categories 
¦ DOMAIN 
¦ KINGDOM 
¦ CHORDATA 
¦ PHYLUM 
¦ CLASS 
¦ ORDER 
¦ FAMILY 
¦ GENUS 
¦ SPECIES  
 
C. Genetic Variability 
? Genetic variability: differences in each person/individual 
? Only identical twins have exactly identical sets of alleles 
 
Page 4


    
A. NAtural Selection 
? Charles Darwin 
? British naturalist who sailed the world 
? Developed theory of evolution based on natural selection after studying animals on 
Galapagos Islands 
? Observed that there were similar animals on isolated animals, but they each had slight 
variations (ex. Beak shape, neck length, etc.) 
¦ There must have originally been a variety of beak lengths, but only the longest 
ones could survive. Since those with the longest beaks could reproduce better, 
they were more likely to contribute offspring with the same traits to the next 
generation 
? The Origin of Species 
¦ Variation exists in the population and some of this variation is heritable 
¦ Populations tend to make lots of offspring 
¦ Resources are limited, thus a struggle ensues 
¦ Those with better traits (phenotypes) will do a better job getting those resources 
and reproduce more 
¦ The genes that code for “better” traits in the current environment start increasing 
in the population 
? The earth is always changing what what may be good now may not be in 
the future; evolution will always be occurring 
? “Survival of the fittest” 
? Jean-Baptiste Lamarck 
? Widely accepted theory of evolution in Darwin’s 
? Acquired traits inherited and passed onto offspring 
¦ “Law of use and disuse” 
¦ According to Lamarck, giraffes have long necks because they constantly use 
them 
? WRONG 
¦ Changes in somatic cells do not change gametes and thus cannot be passed onto 
offspring 
? Evidence for Evolution 
? Paleontology 
¦ Study of fossils 
¦ Revealed great variety of organisms and the major lines of evolution 
¦ Tend to form in sedimentary rock 
? Biogeography 
¦ Study of the distribution of flora and fauna in the environment 
¦ Related species found in widely separated regions of the world 
¦ Suggests a common ancestor between species 
¦ Ex: pangea 
? Embryology 
 
¦ Study of the development of an organism 
¦ Early stages of vertebrate development all look alike 
? All vertebrates show fishlike “gill slits” 
? Comparative anatomy 
¦ Study of anatomy of various animals 
¦ Vestigial Strucutres 
? Structures with little-no function 
? Remannts of structures that served important functions in the organism’s 
ancestors 
¦ Homologous structures 
? Similar structures that serve different functions 
¦ Analogous structures 
? Same function different structure 
 
? Molecular biology 
¦ Most compelling proof of evolution 
¦ Examining nucleotide/amino acid sequences of different organisms 
¦ Common genes and proteins 
¦ Ex: Hox Genes (body paint controller genes) 
¦ Shared structures help us to understand not only how structures develop but also 
supports shared shared ancestry 
? Artificial Selection 
¦ Humans selecting which organisms reproduce and survive so the future 
generations have traits that humans have selected 
¦ Ex. dog breeds 
B. Common Ancestry 
? Phylogenetic trees 
? Aka cladogram 
? Study the relationships between organisms 
? Begin with common ancestor and then branch out 
? Anytime there is a fork in the road, it is called a common ancestor node 
 
¦ Common ancestors likely do not exist anymore, but they are the point at which 
evolution went in two directions 
? Outgroup 
¦ Related to ingroup but diverged before others 
¦ Serves as reference group 
¦ Always stems from foot of tree 
? Monophyletic=ancestral species+all descendants 
? PAraphyletic=ancestral species+some descendants 
? Polyphyletic=ancestral species+descendants+distantly related organism 
? Taxonomic categories 
¦ DOMAIN 
¦ KINGDOM 
¦ CHORDATA 
¦ PHYLUM 
¦ CLASS 
¦ ORDER 
¦ FAMILY 
¦ GENUS 
¦ SPECIES  
 
C. Genetic Variability 
? Genetic variability: differences in each person/individual 
? Only identical twins have exactly identical sets of alleles 
 
? Survival of a species is dependent on genetic variation, allowing a species to survive in a 
changing environment 
? NAtural selection only occurs if some individuals have more evolutionary fitness and can 
be selected 
? Cause of genetic variability 
? Random mutations 
? DNA polymerase errors 
? Changes to DNA by transposons, etc. 
? Meiosis 
¦ Crossing-over 
¦ Independent assortment 
? Bacteria 
¦ Conjugation 
¦ Transduction 
? Viruses pass around chunks of the bacterial genome during infection 
D. Causes of Evolution 
? Natural selection works internally through random mutations and externally through 
environmental pressures 
? As long as a mutation does not kill an organisms before it reproduces, it may be passed on to the 
next generation 
? Advantages brought about by a mutation will only be apparent until environmental pressure 
occurs 
? Adaptation: variation favored by natural selection 
? Any trati that causes an individual to reproduce better gives that individual evolutionary fitness 
? Sexual selection can also spur evolution 
? Speciation occurs once 2 populations can no longer reproduce together 
? Biological Species Theory 
¦ Species is a group of populations whose members have the potential to interbreed 
in nature and produce fertile, viable offspring 
¦ They do not breed successfully with other populations 
? Catastrophic events speed up natural selection 
? Genetic drift 
? Something that causes a change in a population besides natural selection 
? Caused by random events that drastically reduce the number of individuals in a 
population 
? Bottleneck effect 
¦ Sudden change in environment reduces size of population 
¦ New gene pool is not reflective of original population 
? Founder effect 
¦ Few individuals become so isolated from larger population and establish a new 
popluation that may not be representative of original population 
? Gene Flow 
¦ Tends to make a population more similar 
 
Page 5


    
A. NAtural Selection 
? Charles Darwin 
? British naturalist who sailed the world 
? Developed theory of evolution based on natural selection after studying animals on 
Galapagos Islands 
? Observed that there were similar animals on isolated animals, but they each had slight 
variations (ex. Beak shape, neck length, etc.) 
¦ There must have originally been a variety of beak lengths, but only the longest 
ones could survive. Since those with the longest beaks could reproduce better, 
they were more likely to contribute offspring with the same traits to the next 
generation 
? The Origin of Species 
¦ Variation exists in the population and some of this variation is heritable 
¦ Populations tend to make lots of offspring 
¦ Resources are limited, thus a struggle ensues 
¦ Those with better traits (phenotypes) will do a better job getting those resources 
and reproduce more 
¦ The genes that code for “better” traits in the current environment start increasing 
in the population 
? The earth is always changing what what may be good now may not be in 
the future; evolution will always be occurring 
? “Survival of the fittest” 
? Jean-Baptiste Lamarck 
? Widely accepted theory of evolution in Darwin’s 
? Acquired traits inherited and passed onto offspring 
¦ “Law of use and disuse” 
¦ According to Lamarck, giraffes have long necks because they constantly use 
them 
? WRONG 
¦ Changes in somatic cells do not change gametes and thus cannot be passed onto 
offspring 
? Evidence for Evolution 
? Paleontology 
¦ Study of fossils 
¦ Revealed great variety of organisms and the major lines of evolution 
¦ Tend to form in sedimentary rock 
? Biogeography 
¦ Study of the distribution of flora and fauna in the environment 
¦ Related species found in widely separated regions of the world 
¦ Suggests a common ancestor between species 
¦ Ex: pangea 
? Embryology 
 
¦ Study of the development of an organism 
¦ Early stages of vertebrate development all look alike 
? All vertebrates show fishlike “gill slits” 
? Comparative anatomy 
¦ Study of anatomy of various animals 
¦ Vestigial Strucutres 
? Structures with little-no function 
? Remannts of structures that served important functions in the organism’s 
ancestors 
¦ Homologous structures 
? Similar structures that serve different functions 
¦ Analogous structures 
? Same function different structure 
 
? Molecular biology 
¦ Most compelling proof of evolution 
¦ Examining nucleotide/amino acid sequences of different organisms 
¦ Common genes and proteins 
¦ Ex: Hox Genes (body paint controller genes) 
¦ Shared structures help us to understand not only how structures develop but also 
supports shared shared ancestry 
? Artificial Selection 
¦ Humans selecting which organisms reproduce and survive so the future 
generations have traits that humans have selected 
¦ Ex. dog breeds 
B. Common Ancestry 
? Phylogenetic trees 
? Aka cladogram 
? Study the relationships between organisms 
? Begin with common ancestor and then branch out 
? Anytime there is a fork in the road, it is called a common ancestor node 
 
¦ Common ancestors likely do not exist anymore, but they are the point at which 
evolution went in two directions 
? Outgroup 
¦ Related to ingroup but diverged before others 
¦ Serves as reference group 
¦ Always stems from foot of tree 
? Monophyletic=ancestral species+all descendants 
? PAraphyletic=ancestral species+some descendants 
? Polyphyletic=ancestral species+descendants+distantly related organism 
? Taxonomic categories 
¦ DOMAIN 
¦ KINGDOM 
¦ CHORDATA 
¦ PHYLUM 
¦ CLASS 
¦ ORDER 
¦ FAMILY 
¦ GENUS 
¦ SPECIES  
 
C. Genetic Variability 
? Genetic variability: differences in each person/individual 
? Only identical twins have exactly identical sets of alleles 
 
? Survival of a species is dependent on genetic variation, allowing a species to survive in a 
changing environment 
? NAtural selection only occurs if some individuals have more evolutionary fitness and can 
be selected 
? Cause of genetic variability 
? Random mutations 
? DNA polymerase errors 
? Changes to DNA by transposons, etc. 
? Meiosis 
¦ Crossing-over 
¦ Independent assortment 
? Bacteria 
¦ Conjugation 
¦ Transduction 
? Viruses pass around chunks of the bacterial genome during infection 
D. Causes of Evolution 
? Natural selection works internally through random mutations and externally through 
environmental pressures 
? As long as a mutation does not kill an organisms before it reproduces, it may be passed on to the 
next generation 
? Advantages brought about by a mutation will only be apparent until environmental pressure 
occurs 
? Adaptation: variation favored by natural selection 
? Any trati that causes an individual to reproduce better gives that individual evolutionary fitness 
? Sexual selection can also spur evolution 
? Speciation occurs once 2 populations can no longer reproduce together 
? Biological Species Theory 
¦ Species is a group of populations whose members have the potential to interbreed 
in nature and produce fertile, viable offspring 
¦ They do not breed successfully with other populations 
? Catastrophic events speed up natural selection 
? Genetic drift 
? Something that causes a change in a population besides natural selection 
? Caused by random events that drastically reduce the number of individuals in a 
population 
? Bottleneck effect 
¦ Sudden change in environment reduces size of population 
¦ New gene pool is not reflective of original population 
? Founder effect 
¦ Few individuals become so isolated from larger population and establish a new 
popluation that may not be representative of original population 
? Gene Flow 
¦ Tends to make a population more similar 
 
¦ When a poppulation gains/loses alles by genetic additions/subtractions from 
population 
? Only a few individuals are left to mate and regrow a population, so their traits become 
overemphasized without necessarily having any reproductive advantage 
? Types of SElection 
? Directional selection favors one extreme of the normal distribution 
? Stabilizing selection: extreme traits are selected against 
? Disruptive selection favors both extremes,common traits selected against 
 
E. Species 
? Divergent evolution 
? In order for a population to split into different species, they must be reproductively 
isolated 
? Allows the two groups to undergo natural selection and evolve differently 
? a population evolves into 2 separate species due to different variation/environmental 
pressures until the 2 groups can no longer mate together 
? Prezygotic barriers prevent fertilization 
¦ Habitat isolation 
? 2 species don’t encounter each other 
? Same geographic area, but different habitats 
¦ Temporal Isolation 
? Species breed during different times of da/season/etc. 
¦ Behavioral Isolation 
? Different courting rituals 
? Species do not respond to mating signals 
¦ MEchanical isolation 
? Unsuccessful mating attempt 
? Species are anatomically incompatible 
¦ Gametic isolation 
? Sperm unable to fertilize eggs 
? Gametes are unable to fuse to forma zygote 
? Post-zygotic barriers are related to the inability of the hybrid to survive/reproduce 
¦ Reduced hybrid viability 
 
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FAQs on Cheatsheet: Natural Selection - AP Biology - Grade 9

1. What is natural selection and how does it work?
Ans.Natural selection is a process in evolution where organisms that are better adapted to their environment tend to survive and reproduce more than those that are less well adapted. This process involves variation in traits, competition for resources, and the survival of the fittest, leading to the gradual evolution of species over time.
2. Who proposed the theory of natural selection and when?
Ans.The theory of natural selection was proposed by Charles Darwin in the 19th century. His landmark work, "On the Origin of Species," published in 1859, outlined the principles of natural selection and provided evidence from various fields such as biology and geology to support his ideas.
3. What are the main components of natural selection?
Ans.The main components of natural selection include variation, inheritance, high rate of population growth, and differential survival and reproduction. Variation refers to the differences in traits among individuals in a population, inheritance is the passing of traits from parents to offspring, and differential survival means that individuals with advantageous traits are more likely to survive and reproduce.
4. How does natural selection lead to evolution?
Ans.Natural selection leads to evolution by favoring the propagation of advantageous traits within a population. Over generations, these traits become more common, resulting in changes in the population's genetic makeup. This gradual accumulation of changes can lead to the development of new species, as populations adapt to their environments.
5. Can natural selection occur in modern times, and if so, how?
Ans.Yes, natural selection can occur in modern times. It is still at work as organisms continue to adapt to changing environments, such as climate change, antibiotic resistance in bacteria, and urbanization. These factors create new challenges and opportunities for survival, influencing which traits are favored in contemporary populations.
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