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EMBL 
Institute of Life Long Learning 0 
 
 
 
 
 
 
 
Subject : Bioinformatic  
Lesson : European Molecular Biology Laboratory (EMBL) 
Lesson Developer: Sandip Das 
Department/ College: Department of Botany, University of Delhi 
Page 2


EMBL 
Institute of Life Long Learning 0 
 
 
 
 
 
 
 
Subject : Bioinformatic  
Lesson : European Molecular Biology Laboratory (EMBL) 
Lesson Developer: Sandip Das 
Department/ College: Department of Botany, University of Delhi 
EMBL 
Institute of Life Long Learning 1 
   
 
Table of Contents Contents 
 Chapter : European Molecular Biology Laboratory  
?  Introduction 
 European Bioinformatics Institute 
? Databases at EBI 
? Nucleotide databases 
? Functional Genomics Databases 
? Protein databases 
? Structure databases 
? Sequence Analysis 
? Pairwise analysis 
? Multiple sequence alignment 
? Homology Searching 
? Summary  
? Exercises 
? Glossary 
? References  
 
 
 
 
 
 
 
 
 
 
 
Page 3


EMBL 
Institute of Life Long Learning 0 
 
 
 
 
 
 
 
Subject : Bioinformatic  
Lesson : European Molecular Biology Laboratory (EMBL) 
Lesson Developer: Sandip Das 
Department/ College: Department of Botany, University of Delhi 
EMBL 
Institute of Life Long Learning 1 
   
 
Table of Contents Contents 
 Chapter : European Molecular Biology Laboratory  
?  Introduction 
 European Bioinformatics Institute 
? Databases at EBI 
? Nucleotide databases 
? Functional Genomics Databases 
? Protein databases 
? Structure databases 
? Sequence Analysis 
? Pairwise analysis 
? Multiple sequence alignment 
? Homology Searching 
? Summary  
? Exercises 
? Glossary 
? References  
 
 
 
 
 
 
 
 
 
 
 
EMBL 
Institute of Life Long Learning 2 
 
 
 
Introduction  
Keeping with the tremendous growth in field of computational biology, a need was felt to 
establish an independent and parallel research institute that would act not just as a mirror 
housing the Genbank nucleotide resources of NCBI, but would also develop matching 
databases and analysis tools. The European Molecular Biology Laboratory (EMBL) was 
thus established in 1974 and is now supported with funding from 20 members states of the 
European Union (EU), Israel and Australia. EMBL currently operates five research institutes 
in different countries with main institute at Heidelberg, Germany. 
The five institutes of EMBL with their core research activities are (http://www.embl.org/): 
a. EMBL Heidelberg (Germany; http://www.embl.de/) 
b. EMBL Grenoble (France; http://www.embl.fr/index.php)- Structural Biology 
c. EMBL-European Bioinformatics Institute (EBI) Hinxton (UK; http://www.ebi.ac.uk/)- 
Bioinformatics 
d. EMBL Hamburg (Germany; http://www.embl-hamburg.de/index.php) Structural 
Biology 
e. EMBL Monterotondo (Italy; http://www.embl.it/index.php)- Mouse Biology 
 
The broad goals of EMBL are: 
a. Basic research in Molecular biology 
b. Training manpower i.e. students, scientist and visitors 
c. Develop new tools, technologies and methods 
d. Offer service to the research community 
e. Transfer technology to industry for commercialization 
 
Page 4


EMBL 
Institute of Life Long Learning 0 
 
 
 
 
 
 
 
Subject : Bioinformatic  
Lesson : European Molecular Biology Laboratory (EMBL) 
Lesson Developer: Sandip Das 
Department/ College: Department of Botany, University of Delhi 
EMBL 
Institute of Life Long Learning 1 
   
 
Table of Contents Contents 
 Chapter : European Molecular Biology Laboratory  
?  Introduction 
 European Bioinformatics Institute 
? Databases at EBI 
? Nucleotide databases 
? Functional Genomics Databases 
? Protein databases 
? Structure databases 
? Sequence Analysis 
? Pairwise analysis 
? Multiple sequence alignment 
? Homology Searching 
? Summary  
? Exercises 
? Glossary 
? References  
 
 
 
 
 
 
 
 
 
 
 
EMBL 
Institute of Life Long Learning 2 
 
 
 
Introduction  
Keeping with the tremendous growth in field of computational biology, a need was felt to 
establish an independent and parallel research institute that would act not just as a mirror 
housing the Genbank nucleotide resources of NCBI, but would also develop matching 
databases and analysis tools. The European Molecular Biology Laboratory (EMBL) was 
thus established in 1974 and is now supported with funding from 20 members states of the 
European Union (EU), Israel and Australia. EMBL currently operates five research institutes 
in different countries with main institute at Heidelberg, Germany. 
The five institutes of EMBL with their core research activities are (http://www.embl.org/): 
a. EMBL Heidelberg (Germany; http://www.embl.de/) 
b. EMBL Grenoble (France; http://www.embl.fr/index.php)- Structural Biology 
c. EMBL-European Bioinformatics Institute (EBI) Hinxton (UK; http://www.ebi.ac.uk/)- 
Bioinformatics 
d. EMBL Hamburg (Germany; http://www.embl-hamburg.de/index.php) Structural 
Biology 
e. EMBL Monterotondo (Italy; http://www.embl.it/index.php)- Mouse Biology 
 
The broad goals of EMBL are: 
a. Basic research in Molecular biology 
b. Training manpower i.e. students, scientist and visitors 
c. Develop new tools, technologies and methods 
d. Offer service to the research community 
e. Transfer technology to industry for commercialization 
 
EMBL 
Institute of Life Long Learning 3 
We would limit ourselves to the bioinformatics research, database and facilities of EMBL 
that is located at EMBL-EBI in the following sections. 
 
European Bioinformatics Institute (EBI) 
The European Bioinformatics Institute (EBI-EMBL) was established in 1980 as the EMBL 
Nucleotide Sequence Data Library at Heidelberg and in-fact was the world’s first public 
nucleotide database preceding NCBI by eight years (NCBI was established in 1988) with an 
objective to create database of published nucleotide sequences. Subsequently in 1992, the 
EMBL decided to establish EBI as a dedicated research cum analysis facility at the Wellcome 
Trust Genome Campus, Hinxton (UK) in close proximity to Sanger Sequencing Center.  
At present, EBI-EMBL houses databases and provides service and analysis tools for all major 
research disciplines requiring computational support. In addition, EBI is also a partner and 
coordinator for International Nucleotide Sequence Database Collaboration (INSDC; 
http://www.insdc.org) for public domain nucleotide sequence information together with 
Genbank at NCBI (www.ncbi.nim.nih.gov) and DNA databank of Japan (DDBJ; 
www.ddbj.nig.ac.jp).  
The following are the broad categories of databases at EBI-EMBL: 
a. Biological Ontologies 
b. Literature 
c. Functional Genomics or microarray 
d. Nucleotides 
e. Pathways and Networks 
f. Protein 
g. Proteomics 
h. Small Molecules 
i. Structure 
 
Page 5


EMBL 
Institute of Life Long Learning 0 
 
 
 
 
 
 
 
Subject : Bioinformatic  
Lesson : European Molecular Biology Laboratory (EMBL) 
Lesson Developer: Sandip Das 
Department/ College: Department of Botany, University of Delhi 
EMBL 
Institute of Life Long Learning 1 
   
 
Table of Contents Contents 
 Chapter : European Molecular Biology Laboratory  
?  Introduction 
 European Bioinformatics Institute 
? Databases at EBI 
? Nucleotide databases 
? Functional Genomics Databases 
? Protein databases 
? Structure databases 
? Sequence Analysis 
? Pairwise analysis 
? Multiple sequence alignment 
? Homology Searching 
? Summary  
? Exercises 
? Glossary 
? References  
 
 
 
 
 
 
 
 
 
 
 
EMBL 
Institute of Life Long Learning 2 
 
 
 
Introduction  
Keeping with the tremendous growth in field of computational biology, a need was felt to 
establish an independent and parallel research institute that would act not just as a mirror 
housing the Genbank nucleotide resources of NCBI, but would also develop matching 
databases and analysis tools. The European Molecular Biology Laboratory (EMBL) was 
thus established in 1974 and is now supported with funding from 20 members states of the 
European Union (EU), Israel and Australia. EMBL currently operates five research institutes 
in different countries with main institute at Heidelberg, Germany. 
The five institutes of EMBL with their core research activities are (http://www.embl.org/): 
a. EMBL Heidelberg (Germany; http://www.embl.de/) 
b. EMBL Grenoble (France; http://www.embl.fr/index.php)- Structural Biology 
c. EMBL-European Bioinformatics Institute (EBI) Hinxton (UK; http://www.ebi.ac.uk/)- 
Bioinformatics 
d. EMBL Hamburg (Germany; http://www.embl-hamburg.de/index.php) Structural 
Biology 
e. EMBL Monterotondo (Italy; http://www.embl.it/index.php)- Mouse Biology 
 
The broad goals of EMBL are: 
a. Basic research in Molecular biology 
b. Training manpower i.e. students, scientist and visitors 
c. Develop new tools, technologies and methods 
d. Offer service to the research community 
e. Transfer technology to industry for commercialization 
 
EMBL 
Institute of Life Long Learning 3 
We would limit ourselves to the bioinformatics research, database and facilities of EMBL 
that is located at EMBL-EBI in the following sections. 
 
European Bioinformatics Institute (EBI) 
The European Bioinformatics Institute (EBI-EMBL) was established in 1980 as the EMBL 
Nucleotide Sequence Data Library at Heidelberg and in-fact was the world’s first public 
nucleotide database preceding NCBI by eight years (NCBI was established in 1988) with an 
objective to create database of published nucleotide sequences. Subsequently in 1992, the 
EMBL decided to establish EBI as a dedicated research cum analysis facility at the Wellcome 
Trust Genome Campus, Hinxton (UK) in close proximity to Sanger Sequencing Center.  
At present, EBI-EMBL houses databases and provides service and analysis tools for all major 
research disciplines requiring computational support. In addition, EBI is also a partner and 
coordinator for International Nucleotide Sequence Database Collaboration (INSDC; 
http://www.insdc.org) for public domain nucleotide sequence information together with 
Genbank at NCBI (www.ncbi.nim.nih.gov) and DNA databank of Japan (DDBJ; 
www.ddbj.nig.ac.jp).  
The following are the broad categories of databases at EBI-EMBL: 
a. Biological Ontologies 
b. Literature 
c. Functional Genomics or microarray 
d. Nucleotides 
e. Pathways and Networks 
f. Protein 
g. Proteomics 
h. Small Molecules 
i. Structure 
 
EMBL 
Institute of Life Long Learning 4 
 
Figure: Webportal of EMBL and EBI 
Source: http://www.embl.org/ , http://www.ebi.ac.uk/ 
 
Databases at EBI 
The following section will deal with selected databases of EBI-EMBL: 
Nucleotide databases 
a. European Nucleotide Archive (ENA): ENA receives nucleotide data from a variety of 
sources, including small scale sequencing studies, sequencing centers and the INSDC (i.e. 
Genbank and DDBJ). In order to better manage the sequencing resources, ENA has been 
divided in several sub-databases such as  
? ENA-Genome - for genome sequencing data 
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16 docs

FAQs on Lecture 9 - European Molecular Biology Laboratory (EMBL) - Bioinformatics - Botany

1. What is the European Molecular Biology Laboratory (EMBL) Botany?
Ans. The European Molecular Biology Laboratory (EMBL) Botany is a research institution dedicated to the study of molecular biology in plants. It focuses on understanding the molecular mechanisms underlying plant development, growth, and response to environmental stimuli.
2. What kind of research is conducted at the EMBL Botany?
Ans. At the EMBL Botany, research is conducted on various aspects of plant biology, including plant development, plant-microbe interactions, plant genetics, and plant evolution. Scientists at EMBL Botany utilize cutting-edge molecular biology techniques to study these processes in order to gain insights into plant biology.
3. How does the EMBL Botany contribute to the field of plant biology?
Ans. The EMBL Botany contributes to the field of plant biology by conducting research that expands our knowledge of the molecular mechanisms underlying plant growth, development, and response to the environment. This research provides valuable insights into plant biology and has the potential to contribute to the development of sustainable agricultural practices and the improvement of crop yields.
4. Are there any collaborations between the EMBL Botany and other research institutions?
Ans. Yes, the EMBL Botany actively collaborates with other research institutions and universities around the world. These collaborations allow for the exchange of ideas, expertise, and resources, fostering a collaborative and interdisciplinary approach to plant biology research. Collaborations also enable scientists at EMBL Botany to tackle complex research questions and address challenges in the field.
5. Can students or researchers apply to work at the EMBL Botany?
Ans. Yes, students and researchers can apply to work at the EMBL Botany. The institution offers various training and career opportunities for scientists at different stages of their careers. This includes PhD programs, postdoctoral fellowships, and research positions. Interested individuals can visit the EMBL Botany's website for more information on how to apply and the available opportunities.
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