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Page 1 Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi Subject: Bioinformatics Lesson: Applications of Bioinformatics Lesson Developer: Arun Jagannath College/ Department: Sri Venkateswara College, University of Delhi Page 2 Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi Subject: Bioinformatics Lesson: Applications of Bioinformatics Lesson Developer: Arun Jagannath College/ Department: Sri Venkateswara College, University of Delhi Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 1 Table of Contents Chapter: Applications of Bioinformatics ? Introduction ? Bioinformatics and Genomics ? Genome and genome sequencing projects ? The Human Genome Project (HGP) ? Gene prediction methods ? Comparative genomics and functional genomics ? Pharmacogenomics ? Next Generation Sequencing ? Bioinformatics and Protein Structure Prediction ? Levels of protein architecture ? Explosion in the growth of biological sequence and structure data ? Computational approaches to protein structure prediction ? Bioinformatics in Drug Discovery and Development ? Drug Discovery & Development: A difficult and expensive problem ? Where computational techniques are used? ? Target identification and validation ? Target Structure Prediction ? Binding Site Identification and Characterization Page 3 Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi Subject: Bioinformatics Lesson: Applications of Bioinformatics Lesson Developer: Arun Jagannath College/ Department: Sri Venkateswara College, University of Delhi Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 1 Table of Contents Chapter: Applications of Bioinformatics ? Introduction ? Bioinformatics and Genomics ? Genome and genome sequencing projects ? The Human Genome Project (HGP) ? Gene prediction methods ? Comparative genomics and functional genomics ? Pharmacogenomics ? Next Generation Sequencing ? Bioinformatics and Protein Structure Prediction ? Levels of protein architecture ? Explosion in the growth of biological sequence and structure data ? Computational approaches to protein structure prediction ? Bioinformatics in Drug Discovery and Development ? Drug Discovery & Development: A difficult and expensive problem ? Where computational techniques are used? ? Target identification and validation ? Target Structure Prediction ? Binding Site Identification and Characterization Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 2 ? Lead Identification Strategies ? Structure-based approaches- Virtual Screening by Docking ? Ligand-based approaches ? Lead Optimization ? Bioinformatics and Metabolomics ? Systems Biology: Application & Future Prospects ? From OMICS to systems biology ? Complexity of complex disorders ? Systems Pharmacology ? Summary ? Exercise/ Practice ? Glossary ? References/ Bibliography/ Further Reading Page 4 Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi Subject: Bioinformatics Lesson: Applications of Bioinformatics Lesson Developer: Arun Jagannath College/ Department: Sri Venkateswara College, University of Delhi Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 1 Table of Contents Chapter: Applications of Bioinformatics ? Introduction ? Bioinformatics and Genomics ? Genome and genome sequencing projects ? The Human Genome Project (HGP) ? Gene prediction methods ? Comparative genomics and functional genomics ? Pharmacogenomics ? Next Generation Sequencing ? Bioinformatics and Protein Structure Prediction ? Levels of protein architecture ? Explosion in the growth of biological sequence and structure data ? Computational approaches to protein structure prediction ? Bioinformatics in Drug Discovery and Development ? Drug Discovery & Development: A difficult and expensive problem ? Where computational techniques are used? ? Target identification and validation ? Target Structure Prediction ? Binding Site Identification and Characterization Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 2 ? Lead Identification Strategies ? Structure-based approaches- Virtual Screening by Docking ? Ligand-based approaches ? Lead Optimization ? Bioinformatics and Metabolomics ? Systems Biology: Application & Future Prospects ? From OMICS to systems biology ? Complexity of complex disorders ? Systems Pharmacology ? Summary ? Exercise/ Practice ? Glossary ? References/ Bibliography/ Further Reading Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 3 Introduction Bioinformatics is the application of IT to address a biological data. Bioinformatics helps us in understanding biological processes and involves development and application of computational techniques to analyse and interpret a biological problem. Major research efforts in the area of bioinformatics and computational biology include sequence alignment, genome annotation, prediction of protein structure and drug discovery. The challenges facing bioinformatics and areas of potential applications are shown below- Figure : Challenges in bioinformatics Source: Author Page 5 Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi Subject: Bioinformatics Lesson: Applications of Bioinformatics Lesson Developer: Arun Jagannath College/ Department: Sri Venkateswara College, University of Delhi Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 1 Table of Contents Chapter: Applications of Bioinformatics ? Introduction ? Bioinformatics and Genomics ? Genome and genome sequencing projects ? The Human Genome Project (HGP) ? Gene prediction methods ? Comparative genomics and functional genomics ? Pharmacogenomics ? Next Generation Sequencing ? Bioinformatics and Protein Structure Prediction ? Levels of protein architecture ? Explosion in the growth of biological sequence and structure data ? Computational approaches to protein structure prediction ? Bioinformatics in Drug Discovery and Development ? Drug Discovery & Development: A difficult and expensive problem ? Where computational techniques are used? ? Target identification and validation ? Target Structure Prediction ? Binding Site Identification and Characterization Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 2 ? Lead Identification Strategies ? Structure-based approaches- Virtual Screening by Docking ? Ligand-based approaches ? Lead Optimization ? Bioinformatics and Metabolomics ? Systems Biology: Application & Future Prospects ? From OMICS to systems biology ? Complexity of complex disorders ? Systems Pharmacology ? Summary ? Exercise/ Practice ? Glossary ? References/ Bibliography/ Further Reading Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 3 Introduction Bioinformatics is the application of IT to address a biological data. Bioinformatics helps us in understanding biological processes and involves development and application of computational techniques to analyse and interpret a biological problem. Major research efforts in the area of bioinformatics and computational biology include sequence alignment, genome annotation, prediction of protein structure and drug discovery. The challenges facing bioinformatics and areas of potential applications are shown below- Figure : Challenges in bioinformatics Source: Author Applications of Bioinformatics Institute of Lifelong Learning, University of Delhi 4 Figure: Major research areas in bioinformatics Source: Author Bioinformatics and Genomics Genome and Genome Sequencing Projects The word "genome" was coined by Hans Winkler from the German “Genom” in as early as 1926. The total DNA present in a given cell is called genome. In most cells, the genome is packed into two sets of chromosomes, one set from maternal and another one set from paternal inheritance. These chromosomes are composed of 3 billion base pairs of DNA. The four nucleotides (letters) that make up DNA are A, T, G, and C. Just like the alphabets in a sentence in a book make words to tell a story, same do letters of the four bases – A, T, G, C in our genomes. Genomics is the study of the genomes that make up the genetic material of organism. Genome studies include sequencing of the complete DNA sequence in a genome and also include gene annotation for understanding the structural and functional aspects of the genome.Read More
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1. What is bioinformatics and how is it applied in botany? |
2. How does bioinformatics help in studying plant genomics? |
3. What are the applications of bioinformatics in plant transcriptomics? |
4. How can bioinformatics be used to study plant proteomics? |
5. What role does bioinformatics play in plant metabolomics? |
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