Schotten-Baumann reaction is a reaction ofphenols with [1994]a)Benzoyl...
The function of NaOH is
(i) To convert phenol to more stronger
nucleophile PhO–
(ii) To neutralize the acid formed
View all questions of this test
Schotten-Baumann reaction is a reaction ofphenols with [1994]a)Benzoyl...
Explanation:
Schotten-Baumann reaction:
The Schotten-Baumann reaction is a reaction of phenols with benzoyl chloride and sodium hydroxide. This reaction is commonly used to acylate phenols to form esters.
Reaction:
Phenol + Benzoyl chloride + Sodium hydroxide → Phenyl benzoate + Sodium chloride + Water
Mechanism:
1. The reaction begins with the nucleophilic attack of the hydroxide ion from sodium hydroxide on the benzoyl chloride, forming a reactive acyl-oxygen intermediate.
2. The phenol then attacks the acyl-oxygen intermediate, resulting in the formation of the ester product.
3. The final products are phenyl benzoate, sodium chloride, and water.
Significance:
The Schotten-Baumann reaction is a useful method for synthesizing esters from phenols. Ester formation is important in organic chemistry for the synthesis of various compounds.
Applications:
- The Schotten-Baumann reaction is commonly used in the pharmaceutical industry for the synthesis of drug molecules.
- It is also utilized in the production of fragrances, flavors, and other fine chemicals.
Conclusion:
The Schotten-Baumann reaction involving phenols, benzoyl chloride, and sodium hydroxide is a significant method for the formation of esters. This reaction finds wide applications in organic synthesis, particularly in the pharmaceutical and fragrance industries.