Tissue without Basement Membrane

Basement membrane is a specialized extracellular matrix that separates epithelial and endothelial cells from underlying connective tissues. However, not all tissues possess a basement membrane. Some of the tissues that do not have a basement membrane are:

1. Blood vessels: The inner lining of blood vessels, known as endothelium, lacks a basement membrane. This is because the endothelial cells are in direct contact with the blood flow and require a permeable surface to allow for exchange of nutrients and waste products.


2. Lymphatic vessels: Similar to blood vessels, the lymphatic vessels also lack a basement membrane. The lymphatic endothelium allows for the movement of lymph fluid and immune cells through the vessel walls.


3. Peripheral nerve fibers: The Schwann cells that encase peripheral nerve fibers do not form a basement membrane. Instead, they form a specialized extracellular matrix called the basal lamina, which helps to support and protect the nerve fibers.


4. Skeletal muscle fibers: The individual muscle fibers that make up skeletal muscle do not have a basement membrane. Instead, they are surrounded by a layer of connective tissue called the endomysium.

Why do these tissues lack a basement membrane?

The lack of a basement membrane in these tissues is due to their unique functions and interactions with their surrounding environment. For example, the endothelial cells in blood and lymphatic vessels need to be able to transport molecules and cells in and out of the vessels, which requires a more permeable surface than a basement membrane would provide. Similarly, the Schwann cells that surround peripheral nerve fibers need to be able to support and protect the fibers while allowing for their movement and communication with other cells.

In conclusion, while many tissues in the body have a basement membrane, some do not due to their specialized functions and interactions with their environment. Understanding these differences can help researchers develop better treatments and therapies for a variety of diseases and conditions.

Epithelial tissue no have basement membrane.