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Phosphorylase kinase is activated by hormones that lead to the phosphorylation of the  subunit and by Ca2+ binding of the  subunit. Both types of stimulation are required for maximal enzyme activity as shown in the figure below:
Which of the following mutation at the active site of phosphorylase is likely to inhibit the regulation of above protein ?
  • a)
    S123L
  • b)
    S123T
  • c)
    S123Y
  • d)
    S123H
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
Phosphorylase kinase is activated by hormones that lead to the phospho...
S123L means serine at 123 poition in the protein is replaced by leucine. In this case nature of amino acid changes as leucine does not allow phosphorylation, therefore option (a) is correct. Serine, Threonine and tyrosine are most commonly phosphorylated amino acids. Histidine is phosphorylated in prokaryotes and plants (now, also known to be phosphorylated in human also).
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Phosphorylase kinase is activated by hormones that lead to the phosphorylation of the subunit and by Ca2+binding of the subunit. Both types of stimulation are required for maximal enzyme activity as shown in the figure below:Which of the following mutation at the active site of phosphorylase is likely to inhibit the regulation of above protein ?a)S123Lb)S123Tc)S123Yd)S123HCorrect answer is option 'A'. Can you explain this answer?
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Phosphorylase kinase is activated by hormones that lead to the phosphorylation of the subunit and by Ca2+binding of the subunit. Both types of stimulation are required for maximal enzyme activity as shown in the figure below:Which of the following mutation at the active site of phosphorylase is likely to inhibit the regulation of above protein ?a)S123Lb)S123Tc)S123Yd)S123HCorrect answer is option 'A'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Phosphorylase kinase is activated by hormones that lead to the phosphorylation of the subunit and by Ca2+binding of the subunit. Both types of stimulation are required for maximal enzyme activity as shown in the figure below:Which of the following mutation at the active site of phosphorylase is likely to inhibit the regulation of above protein ?a)S123Lb)S123Tc)S123Yd)S123HCorrect answer is option 'A'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Phosphorylase kinase is activated by hormones that lead to the phosphorylation of the subunit and by Ca2+binding of the subunit. Both types of stimulation are required for maximal enzyme activity as shown in the figure below:Which of the following mutation at the active site of phosphorylase is likely to inhibit the regulation of above protein ?a)S123Lb)S123Tc)S123Yd)S123HCorrect answer is option 'A'. Can you explain this answer?.
Solutions for Phosphorylase kinase is activated by hormones that lead to the phosphorylation of the subunit and by Ca2+binding of the subunit. Both types of stimulation are required for maximal enzyme activity as shown in the figure below:Which of the following mutation at the active site of phosphorylase is likely to inhibit the regulation of above protein ?a)S123Lb)S123Tc)S123Yd)S123HCorrect answer is option 'A'. Can you explain this answer? in English & in Hindi are available as part of our courses for IIT JAM. Download more important topics, notes, lectures and mock test series for IIT JAM Exam by signing up for free.
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