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Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?
- a)Ceramide
- b)Cardiolipin
- c)Platlet activating factor
- d)Dipalmitoylphosphatidylcholine
Correct answer is option 'B'. Can you explain this answer?
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Verified Answer
Autoantibodies to a lipid in the membrane of platelets are seen in the...
Systemic lupus erythematosus (SLE) is an autoimmune disease in which the body’s immune system mistakenly attacks healthy tissue in many parts of the body including platelets.
People with SLE have low platelet and white blood cell counts because autoantibodies against cardiolipin present in membrane are made. Anti cardiolipin antibodies are antibodies often directed against cardiolipin and found in diseases such as systemic lupus erythematosus (SLE).
In mammalian cells, cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism. Cardiolipin is exclusively present in mitochondria
People with SLE have low platelet and white blood cell counts because autoantibodies against cardiolipin present in membrane are made. Anti cardiolipin antibodies are antibodies often directed against cardiolipin and found in diseases such as systemic lupus erythematosus (SLE).
In mammalian cells, cardiolipin (CL) is found almost exclusively in the inner mitochondrial membrane where it is essential for the optimal function of numerous enzymes that are involved in mitochondrial energy metabolism. Cardiolipin is exclusively present in mitochondria
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Autoantibodies to a lipid in the membrane of platelets are seen in the...
Lipids in the Membrane of Platelets in Systemic Lupus Erythematosus (SLE)
In systemic lupus erythematosus (SLE), autoantibodies are produced against various components of the body, including the membrane lipids of platelets. These autoantibodies can lead to the formation of immune complexes and contribute to the pathogenesis of SLE.
Identification of the Most Likely Involved Membrane Lipid
Among the options provided, the most likely membrane lipid to be involved in SLE is cardiolipin (option B). Here's why:
1. Ceramide (option A): Ceramide is a sphingolipid that plays a role in various cellular processes. It is not typically found in high abundance in platelet membranes, and autoantibodies to ceramide are not commonly associated with SLE.
2. Platelet activating factor (option C): Platelet activating factor (PAF) is a phospholipid that is involved in platelet activation and inflammation. While PAF can be targeted by autoantibodies in certain diseases, it is not the primary lipid target in SLE.
3. Dipalmitoylphosphatidylcholine (option D): Dipalmitoylphosphatidylcholine (DPPC) is a major component of lung surfactant and is not typically present in high levels in platelet membranes. Autoantibodies to DPPC are not commonly associated with SLE.
Key Point: The primary lipid target in SLE is cardiolipin (option B).
Role of Cardiolipin in Platelet Membrane and SLE
Cardiolipin is a unique diphosphatidylglycerol lipid that is found primarily in the inner mitochondrial membrane but can also be present in other cell membranes, including platelet membranes. It is involved in various cellular processes, including apoptosis, membrane stability, and cell signaling.
In SLE, autoantibodies against cardiolipin are known as anticardiolipin antibodies (aCL). These antibodies can interact with cardiolipin on platelet membranes, leading to the formation of immune complexes. These immune complexes can activate the complement system and promote inflammation, contributing to the pathogenesis of SLE.
Conclusion: Autoantibodies to cardiolipin are commonly found in SLE and target the cardiolipin present in platelet membranes. These autoantibodies play a significant role in the pathogenesis of SLE by promoting inflammation and immune complex formation.
In systemic lupus erythematosus (SLE), autoantibodies are produced against various components of the body, including the membrane lipids of platelets. These autoantibodies can lead to the formation of immune complexes and contribute to the pathogenesis of SLE.
Identification of the Most Likely Involved Membrane Lipid
Among the options provided, the most likely membrane lipid to be involved in SLE is cardiolipin (option B). Here's why:
1. Ceramide (option A): Ceramide is a sphingolipid that plays a role in various cellular processes. It is not typically found in high abundance in platelet membranes, and autoantibodies to ceramide are not commonly associated with SLE.
2. Platelet activating factor (option C): Platelet activating factor (PAF) is a phospholipid that is involved in platelet activation and inflammation. While PAF can be targeted by autoantibodies in certain diseases, it is not the primary lipid target in SLE.
3. Dipalmitoylphosphatidylcholine (option D): Dipalmitoylphosphatidylcholine (DPPC) is a major component of lung surfactant and is not typically present in high levels in platelet membranes. Autoantibodies to DPPC are not commonly associated with SLE.
Key Point: The primary lipid target in SLE is cardiolipin (option B).
Role of Cardiolipin in Platelet Membrane and SLE
Cardiolipin is a unique diphosphatidylglycerol lipid that is found primarily in the inner mitochondrial membrane but can also be present in other cell membranes, including platelet membranes. It is involved in various cellular processes, including apoptosis, membrane stability, and cell signaling.
In SLE, autoantibodies against cardiolipin are known as anticardiolipin antibodies (aCL). These antibodies can interact with cardiolipin on platelet membranes, leading to the formation of immune complexes. These immune complexes can activate the complement system and promote inflammation, contributing to the pathogenesis of SLE.
Conclusion: Autoantibodies to cardiolipin are commonly found in SLE and target the cardiolipin present in platelet membranes. These autoantibodies play a significant role in the pathogenesis of SLE by promoting inflammation and immune complex formation.
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Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer?
Question Description
Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer?.
Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer?.
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Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer?, a detailed solution for Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer? has been provided alongside types of Autoantibodies to a lipid in the membrane of platelets are seen in the disease, systemic lupus erythrematous. Which of the following membrane lipids is most likely to be involved?a)Ceramideb)Cardiolipinc)Platlet activating factord)DipalmitoylphosphatidylcholineCorrect answer is option 'B'. Can you explain this answer? theory, EduRev gives you an
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