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Base pair stacking is a type of stabilizing interaction in the DNA double helix. The exact nature of this interaction is
- a)Pi – pi interactions
- b)Hydrophobic interactions
- c)Covalent interactions
- d)Vander Walls interactions
Correct answer is option 'A'. Can you explain this answer?
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Base pair stacking is a type of stabilizing interaction in the DNA dou...
The base pair stacking interaction are the interaction between pi bonds of the adjacent base pairs.The stability of the DNA double helix depends on a fine balance of interactions including hydrogen bonds between bases, hydrogen bonds between bases and surrounding water molecules, and base-stacking interactions between adjacent bases. Inter-strand hydrogen bonding is clearly important in driving the formation of DNA double strands, but it is by no means the only contributing factor. The individual bases form strong stacking interactions which are major contributors to double strand stability, as base stacking is much more prevalent in double strands than in single strands. Base-stacking interactions are hydrophobic and electrostatic in nature, and depend on the aromaticity of the bases and their dipole moments. Base-stacking interactions in nucleic acid double strands are partly inter-strand and partly intra-strand in nature. However, it is probably more informative to consider base pairs rather than individual bases as discrete units in order to visualize the stabilising effects of base stacking.The degree of stabilization afforded by base stacking depends on the DNA sequence. Some combinations of base pairs form more stable interactions than others, so nearest neighbour base-stacking interactions are important determinants of DNA double strand stability.
Base-stacking interactions increase with increasing salt concentration, as high salt concentrations mask the destabilizing charge repulsion between the two negatively charged phosphodiester backbones. DNA double strand stability therefore increases with increasing salt concentration. Divalent cations such as Mg2+ are more stabilising than Na+ ions, and some metal ions bind to specific loci on the DNA duplex.
Base-stacking interactions increase with increasing salt concentration, as high salt concentrations mask the destabilizing charge repulsion between the two negatively charged phosphodiester backbones. DNA double strand stability therefore increases with increasing salt concentration. Divalent cations such as Mg2+ are more stabilising than Na+ ions, and some metal ions bind to specific loci on the DNA duplex.
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Base pair stacking is a type of stabilizing interaction in the DNA dou...
Stacking interaction.
Pi stacking is a non-covalent interaction between aromatic rings, where the electron cloud of one ring overlaps with the electron cloud of another ring. In DNA, the aromatic rings of the nucleotide bases (adenine, thymine, cytosine, and guanine) can undergo pi stacking interactions with each other.
In base pair stacking, the nitrogenous bases of adjacent base pairs in the DNA double helix come into close contact and form stabilizing interactions. This stacking interaction helps stabilize the overall structure of the DNA double helix and plays a crucial role in maintaining the integrity of the genetic code.
The exact nature of the base pair stacking interaction is complex and involves a combination of hydrogen bonding, Van der Waals forces, and pi stacking interactions. These interactions contribute to the stability and structural integrity of the DNA double helix.
Pi stacking is a non-covalent interaction between aromatic rings, where the electron cloud of one ring overlaps with the electron cloud of another ring. In DNA, the aromatic rings of the nucleotide bases (adenine, thymine, cytosine, and guanine) can undergo pi stacking interactions with each other.
In base pair stacking, the nitrogenous bases of adjacent base pairs in the DNA double helix come into close contact and form stabilizing interactions. This stacking interaction helps stabilize the overall structure of the DNA double helix and plays a crucial role in maintaining the integrity of the genetic code.
The exact nature of the base pair stacking interaction is complex and involves a combination of hydrogen bonding, Van der Waals forces, and pi stacking interactions. These interactions contribute to the stability and structural integrity of the DNA double helix.
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Base pair stacking is a type of stabilizing interaction in the DNA double helix. The exact nature of this interaction isa)Pi – pi interactionsb)Hydrophobic interactionsc)Covalent interactions d)Vander Walls interactionsCorrect answer is option 'A'. Can you explain this answer?
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