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In Phosphoinositol signalling pathway- Extracellular signals promote activation of phospholipase C, which cleaves the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2)into two components, what are these two components?
- a)Protein kinase A
- b)Inositol 1,4,5-trisphosphate (IP3)
- c)Protein kinase C
- d)Diacylglycerol (DAG)
Correct answer is option 'B,D'. Can you explain this answer?
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In Phosphoinositol signalling pathway- Extracellular signals promote a...
Upon activation by phospholipases, phosphoionositol lipids break down into two components a. Diacylglycerol that activates PKC and another IP3 that activates calcium signalling.
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In Phosphoinositol signalling pathway- Extracellular signals promote a...
Components of Phosphoinositol Signalling Pathway:
The phosphoinositol signalling pathway is an intracellular signalling pathway that is activated in response to extracellular signals. This pathway plays a crucial role in many cellular processes, including cell growth, differentiation, and metabolism. One of the key steps in this pathway is the cleavage of the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2) by phospholipase C (PLC). This cleavage generates two components: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG).
Inositol 1,4,5-trisphosphate (IP3):
IP3 is a small, soluble molecule that acts as a second messenger in the phosphoinositol signalling pathway. It is released into the cytoplasm upon cleavage of PIP2 by PLC. IP3 then binds to specific receptors on the endoplasmic reticulum (ER), causing the release of calcium ions (Ca2+) from the ER stores into the cytoplasm. The increase in cytoplasmic calcium levels triggers a variety of downstream signalling events, leading to cellular responses such as gene expression, enzyme activation, and ion channel regulation.
Diacylglycerol (DAG):
DAG is another component generated by the cleavage of PIP2 by PLC. It remains in the plasma membrane and acts as a lipid second messenger. DAG activates protein kinase C (PKC), a family of serine/threonine kinases that play a key role in cellular signalling. Upon activation, PKC phosphorylates target proteins, leading to changes in their activity and cellular responses. DAG also plays a role in regulating membrane trafficking and cytoskeletal reorganization.
Summary:
In summary, the cleavage of phosphatidylinositol 4, 5-bisphosphate (PIP2) by phospholipase C (PLC) in the phosphoinositol signalling pathway generates two components: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 acts as a soluble second messenger that triggers the release of calcium ions from the endoplasmic reticulum, while DAG remains in the plasma membrane and activates protein kinase C. These components play crucial roles in mediating the cellular responses to extracellular signals in various physiological processes.
The phosphoinositol signalling pathway is an intracellular signalling pathway that is activated in response to extracellular signals. This pathway plays a crucial role in many cellular processes, including cell growth, differentiation, and metabolism. One of the key steps in this pathway is the cleavage of the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2) by phospholipase C (PLC). This cleavage generates two components: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG).
Inositol 1,4,5-trisphosphate (IP3):
IP3 is a small, soluble molecule that acts as a second messenger in the phosphoinositol signalling pathway. It is released into the cytoplasm upon cleavage of PIP2 by PLC. IP3 then binds to specific receptors on the endoplasmic reticulum (ER), causing the release of calcium ions (Ca2+) from the ER stores into the cytoplasm. The increase in cytoplasmic calcium levels triggers a variety of downstream signalling events, leading to cellular responses such as gene expression, enzyme activation, and ion channel regulation.
Diacylglycerol (DAG):
DAG is another component generated by the cleavage of PIP2 by PLC. It remains in the plasma membrane and acts as a lipid second messenger. DAG activates protein kinase C (PKC), a family of serine/threonine kinases that play a key role in cellular signalling. Upon activation, PKC phosphorylates target proteins, leading to changes in their activity and cellular responses. DAG also plays a role in regulating membrane trafficking and cytoskeletal reorganization.
Summary:
In summary, the cleavage of phosphatidylinositol 4, 5-bisphosphate (PIP2) by phospholipase C (PLC) in the phosphoinositol signalling pathway generates two components: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 acts as a soluble second messenger that triggers the release of calcium ions from the endoplasmic reticulum, while DAG remains in the plasma membrane and activates protein kinase C. These components play crucial roles in mediating the cellular responses to extracellular signals in various physiological processes.
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In Phosphoinositol signalling pathway- Extracellular signals promote activation of phospholipase C, which cleaves the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2)into two components, what are these two components?a)Protein kinase Ab)Inositol 1,4,5-trisphosphate (IP3)c)Protein kinase Cd)Diacylglycerol (DAG)Correct answer is option 'B,D'. Can you explain this answer?
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In Phosphoinositol signalling pathway- Extracellular signals promote activation of phospholipase C, which cleaves the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2)into two components, what are these two components?a)Protein kinase Ab)Inositol 1,4,5-trisphosphate (IP3)c)Protein kinase Cd)Diacylglycerol (DAG)Correct answer is option 'B,D'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about In Phosphoinositol signalling pathway- Extracellular signals promote activation of phospholipase C, which cleaves the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2)into two components, what are these two components?a)Protein kinase Ab)Inositol 1,4,5-trisphosphate (IP3)c)Protein kinase Cd)Diacylglycerol (DAG)Correct answer is option 'B,D'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for In Phosphoinositol signalling pathway- Extracellular signals promote activation of phospholipase C, which cleaves the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2)into two components, what are these two components?a)Protein kinase Ab)Inositol 1,4,5-trisphosphate (IP3)c)Protein kinase Cd)Diacylglycerol (DAG)Correct answer is option 'B,D'. Can you explain this answer?.
In Phosphoinositol signalling pathway- Extracellular signals promote activation of phospholipase C, which cleaves the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2)into two components, what are these two components?a)Protein kinase Ab)Inositol 1,4,5-trisphosphate (IP3)c)Protein kinase Cd)Diacylglycerol (DAG)Correct answer is option 'B,D'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about In Phosphoinositol signalling pathway- Extracellular signals promote activation of phospholipase C, which cleaves the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2)into two components, what are these two components?a)Protein kinase Ab)Inositol 1,4,5-trisphosphate (IP3)c)Protein kinase Cd)Diacylglycerol (DAG)Correct answer is option 'B,D'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for In Phosphoinositol signalling pathway- Extracellular signals promote activation of phospholipase C, which cleaves the phospholipid phosphatidylinositol 4, 5-bisphosphate (PIP2)into two components, what are these two components?a)Protein kinase Ab)Inositol 1,4,5-trisphosphate (IP3)c)Protein kinase Cd)Diacylglycerol (DAG)Correct answer is option 'B,D'. Can you explain this answer?.
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