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Identify the autoimmune diseases among the following
  • a)
    Type II Diabetes Mellitus 
  • b)
    Type I Diabetes Mellitus
  • c)
    Gestational Diabetes 
  • d)
    Pernicious Anaemia
Correct answer is option 'B,D'. Can you explain this answer?
Verified Answer
Identify the autoimmune diseases among the followinga)Type II Diabetes...
Autoimmunity is a diseased situation when body’s immune system starts to attack and destroy host’s cells and tissues.
Type I diabetes mellitus happens when cells of immune system destroy beta-cells in pancreatic islets of Langerhans.
This leads to drop in insulin production and development of diabetes.
Pernicious anaemia is an autoimmune anaemia. In this, autoantibodies block intrinsic factor, a membrane bound protein on gastric parietal cells. It facilitates absorption of vit. B12. But auto-antibodies block it, so vit. B12 can not be absorbed. Absence of vit. B12 adversely affects proper haematopoiesis and number of functional mature RBCs drops below normal. It leads to anaemia.
While Type II diabetes mellitus and gestational diabetes are related to metabolic imbalances and not autoimmunity.
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Most Upvoted Answer
Identify the autoimmune diseases among the followinga)Type II Diabetes...
Autoimmune Diseases:
Autoimmune diseases are a group of disorders in which the immune system mistakenly attacks the body's own healthy cells and tissues. There are several autoimmune diseases, and among the given options, Type I Diabetes Mellitus and Pernicious Anemia are autoimmune diseases.

Explanation:

Type I Diabetes Mellitus:
- Type I diabetes mellitus, also known as insulin-dependent diabetes or juvenile diabetes, is an autoimmune disease.
- In this condition, the immune system mistakenly attacks and destroys the insulin-producing cells (beta cells) in the pancreas.
- As a result, the body is unable to produce enough insulin, leading to high blood sugar levels.
- This condition usually occurs in childhood or adolescence.

Pernicious Anemia:
- Pernicious anemia is another autoimmune disease.
- It is characterized by the body's inability to absorb vitamin B12 from the diet, leading to a deficiency of this essential nutrient.
- The immune system produces antibodies that attack the cells in the stomach lining that produce a protein called intrinsic factor.
- Intrinsic factor is necessary for the absorption of vitamin B12.
- Without sufficient vitamin B12, the body is unable to produce enough healthy red blood cells, leading to anemia.

Other Options:

Type II Diabetes Mellitus:
- Type II diabetes mellitus is not an autoimmune disease.
- It is a metabolic disorder characterized by insulin resistance, where the body's cells become less responsive to the effects of insulin.
- While there is a genetic component to Type II diabetes, it is not primarily caused by autoimmune mechanisms.
- Lifestyle factors, such as obesity and physical inactivity, play a significant role in the development of Type II diabetes.

Gestational Diabetes:
- Gestational diabetes is a form of diabetes that occurs during pregnancy.
- It is characterized by high blood sugar levels in pregnant women who did not previously have diabetes.
- Gestational diabetes is not considered an autoimmune disease.
- It is believed to result from hormonal changes and increased insulin resistance during pregnancy.

Conclusion:
In conclusion, among the given options, Type I Diabetes Mellitus and Pernicious Anemia are autoimmune diseases. Type II Diabetes Mellitus and Gestational Diabetes are not autoimmune diseases but have different underlying causes.
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Identify the autoimmune diseases among the followinga)Type II Diabetes Mellitusb)Type I Diabetes Mellitusc)Gestational Diabetesd)Pernicious AnaemiaCorrect answer is option 'B,D'. Can you explain this answer?
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