IIT JAM Exam > IIT JAM Questions > Which one of the following statements is a co...
Start Learning for Free
Which one of the following statements is a correct description of modes of action of taxol andcolchicine?
- a)Taxol causes DNA damage and colchicine prevents microtubule formation
- b)Taxol stabilizes microtubules and colchicine inhibits protein synthesis
- c)Taxol destabilizes microtubules and colchicine promotes microtubule formation
- d)Taxol stabilizes microtubules and colchicine prevents microtubule formation
Correct answer is option 'D'. Can you explain this answer?
| FREE This question is part of | Download PDF Attempt this Test |
Most Upvoted Answer
Which one of the following statements is a correct description of mode...
**Correct Answer:**
The correct description of the modes of action of taxol and colchicine is:
**d) Taxol stabilizes microtubules and colchicine prevents microtubule formation.**
**Taxol:**
Taxol, also known as paclitaxel, is a natural compound derived from the bark of the Pacific yew tree. It is an anti-cancer drug that is widely used in the treatment of various types of cancer, including ovarian, breast, and lung cancer.
**Mode of Action of Taxol:**
Taxol exerts its mode of action by binding to a specific site on beta-tubulin, a protein subunit of microtubules. This binding stabilizes microtubules, preventing their depolymerization and promoting the assembly of new microtubules. As a result, taxol enhances microtubule polymerization and inhibits their disassembly.
By stabilizing microtubules, taxol interferes with the normal dynamics of the microtubule network, which is crucial for cellular processes such as cell division, intracellular transport, and maintenance of cell shape. Taxol-induced stabilization of microtubules leads to the disruption of these processes, ultimately causing cell cycle arrest and cell death in cancer cells.
**Colchicine:**
Colchicine is a naturally occurring compound found in the autumn crocus plant. It has been used for centuries to relieve the pain and inflammation associated with gout.
**Mode of Action of Colchicine:**
Colchicine acts by binding to a different site on beta-tubulin than taxol. It interferes with the assembly of microtubules by preventing the polymerization of tubulin subunits into microtubules. Colchicine binds to tubulin dimers and prevents their addition to the growing ends of microtubules, leading to the disruption of microtubule formation.
By inhibiting microtubule formation, colchicine disrupts the normal microtubule network required for various cellular processes. This disruption affects processes such as mitosis, cell division, intracellular transport, and maintenance of cell shape.
**Comparison:**
The modes of action of taxol and colchicine can be summarized as follows:
- Taxol stabilizes microtubules by promoting their assembly and preventing disassembly.
- Colchicine prevents microtubule formation by inhibiting the polymerization of tubulin subunits.
These different modes of action ultimately lead to the disruption of the microtubule network within cells, affecting crucial cellular processes and ultimately causing cell death.
Therefore, option d) "Taxol stabilizes microtubules and colchicine prevents microtubule formation" is the correct description of the modes of action of taxol and colchicine.
The correct description of the modes of action of taxol and colchicine is:
**d) Taxol stabilizes microtubules and colchicine prevents microtubule formation.**
**Taxol:**
Taxol, also known as paclitaxel, is a natural compound derived from the bark of the Pacific yew tree. It is an anti-cancer drug that is widely used in the treatment of various types of cancer, including ovarian, breast, and lung cancer.
**Mode of Action of Taxol:**
Taxol exerts its mode of action by binding to a specific site on beta-tubulin, a protein subunit of microtubules. This binding stabilizes microtubules, preventing their depolymerization and promoting the assembly of new microtubules. As a result, taxol enhances microtubule polymerization and inhibits their disassembly.
By stabilizing microtubules, taxol interferes with the normal dynamics of the microtubule network, which is crucial for cellular processes such as cell division, intracellular transport, and maintenance of cell shape. Taxol-induced stabilization of microtubules leads to the disruption of these processes, ultimately causing cell cycle arrest and cell death in cancer cells.
**Colchicine:**
Colchicine is a naturally occurring compound found in the autumn crocus plant. It has been used for centuries to relieve the pain and inflammation associated with gout.
**Mode of Action of Colchicine:**
Colchicine acts by binding to a different site on beta-tubulin than taxol. It interferes with the assembly of microtubules by preventing the polymerization of tubulin subunits into microtubules. Colchicine binds to tubulin dimers and prevents their addition to the growing ends of microtubules, leading to the disruption of microtubule formation.
By inhibiting microtubule formation, colchicine disrupts the normal microtubule network required for various cellular processes. This disruption affects processes such as mitosis, cell division, intracellular transport, and maintenance of cell shape.
**Comparison:**
The modes of action of taxol and colchicine can be summarized as follows:
- Taxol stabilizes microtubules by promoting their assembly and preventing disassembly.
- Colchicine prevents microtubule formation by inhibiting the polymerization of tubulin subunits.
These different modes of action ultimately lead to the disruption of the microtubule network within cells, affecting crucial cellular processes and ultimately causing cell death.
Therefore, option d) "Taxol stabilizes microtubules and colchicine prevents microtubule formation" is the correct description of the modes of action of taxol and colchicine.
|
Explore Courses for IIT JAM exam
|
|
Similar IIT JAM Doubts
Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer?
Question Description
Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer?.
Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer?.
Solutions for Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer? in English & in Hindi are available as part of our courses for IIT JAM.
Download more important topics, notes, lectures and mock test series for IIT JAM Exam by signing up for free.
Here you can find the meaning of Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer? defined & explained in the simplest way possible. Besides giving the explanation of
Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer?, a detailed solution for Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer? has been provided alongside types of Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer? theory, EduRev gives you an
ample number of questions to practice Which one of the following statements is a correct description of modes of action of taxol andcolchicine?a)Taxol causes DNA damage and colchicine prevents microtubule formationb)Taxol stabilizes microtubules and colchicine inhibits protein synthesisc)Taxol destabilizes microtubules and colchicine promotes microtubule formationd)Taxol stabilizes microtubules and colchicine prevents microtubule formationCorrect answer is option 'D'. Can you explain this answer? tests, examples and also practice IIT JAM tests.
|
|
Explore Courses for IIT JAM exam
|
|
Suggested Free Tests
Signup for Free!
Signup to see your scores go up within 7 days! Learn & Practice with 1000+ FREE Notes, Videos & Tests.
|
© EduRev
|
Education Revolution
|
|
Signup to see your scores
go up within 7 days!
Access 1000+ FREE Docs, Videos and Tests
Takes less than 10 seconds to signup