Detoxification of harmful drugs is the function of the liver. The liver is a vital organ in the human body that plays a critical role in detoxifying harmful substances, including drugs and alcohol. The liver has several specialized cells and structures that work together to break down and remove toxins from the body.

Structure of the Liver
The liver is a large, complex organ that is located in the upper right side of the abdomen. It is composed of several lobes, each of which contains thousands of tiny functional units called lobules. These lobules are made up of various types of cells, including hepatocytes, Kupffer cells, and sinusoidal endothelial cells.

Function of the Liver in Detoxification
The liver is responsible for detoxifying harmful substances, including drugs and alcohol, through a series of complex metabolic processes. The process of detoxification occurs in two phases:

Phase I: In this phase, the liver uses enzymes to break down the harmful substance into smaller, less toxic molecules.

Phase II: In this phase, the liver uses enzymes to attach molecules, such as glutathione, to the broken-down molecules from phase I. This process makes the molecules more water-soluble and easier to eliminate from the body.

The specific enzymes involved in drug detoxification are primarily located in the endoplasmic reticulum (ER) of the liver cells. The ER is composed of two types: rough ER (RER) and smooth ER (SER). The RER contains ribosomes and is involved in protein synthesis, while the SER lacks ribosomes and is involved in lipid synthesis and detoxification.

The detoxification of drugs occurs in the SER, which contains enzymes called cytochrome P450 (CYP) enzymes. These enzymes are responsible for converting drugs into less harmful metabolites that can be eliminated from the body. Other enzymes, such as glucuronidation enzymes, also play a role in drug detoxification.

Conclusion
In conclusion, the liver plays a critical role in detoxifying harmful substances, including drugs and alcohol. The detoxification process occurs in two phases, primarily in the SER of liver cells, which contains enzymes such as CYP and glucuronidation enzymes. The liver's ability to detoxify drugs is essential for maintaining overall health and well-being.

It's 2) SERThe SER(Smooth Endoplasmic Reticulum) brings about detoxification in the liver, i.e., it converts harmful materials (drugs, insecticides, pollutants and poisons) into harmless substances for excretion by the cell.These ER contain such enzymes which have the ability to inactivate the harmful drugs. hope it's clear to u.....