Formation of Columns of Bertin:
The Columns of Bertin are anatomical variations in the renal cortex that are responsible for the formation of inward extensions between the renal pyramids. These columns are composed of renal cortex tissue that projects into the renal medulla, dividing the pyramids and creating a unique appearance on the surface of the kidney.

Location and Structure:
The Columns of Bertin are located between adjacent renal pyramids and extend from the renal cortex into the renal medulla. They are composed of normal renal cortex tissue and are often described as bridges or columns that divide the pyramids. The number, size, and shape of the Columns of Bertin can vary among individuals.

Role of Cortex in the Formation of Columns of Bertin:
The cortex of the kidney is responsible for the formation of the Columns of Bertin. During embryonic development, the renal cortex grows and expands, resulting in the formation of inward extensions known as the Columns of Bertin. These extensions project into the renal medulla and separate the renal pyramids.

Function:
The Columns of Bertin play a structural role in the kidney by providing support and stability to the renal pyramids. They also contribute to the overall surface anatomy of the kidney, giving it a characteristic appearance.

Importance in Medical Imaging:
The Columns of Bertin can have clinical significance in medical imaging, particularly in radiology and urology. They can be mistaken for renal masses or tumors on imaging studies such as CT scans or MRI. Understanding the normal anatomical variations of the kidney, including the presence of Columns of Bertin, is important for accurate interpretation of imaging findings and avoiding unnecessary interventions or treatments.

In conclusion, the formation of Columns of Bertin is primarily attributed to the renal cortex. These inward extensions of the cortex into the medulla play a structural role in supporting the renal pyramids and contribute to the surface anatomy of the kidney.