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Thymine and occasionally cytosine are paired with the base analogue 2-aminopurine base. The kind of mutation that this chemical causes is:
  • a)
    deletion
  • b)
    transition
  • c)
    transversion
  • d)
    point
Correct answer is option 'B'. Can you explain this answer?
Verified Answer
Thymine and occasionally cytosine are paired with the base analogue 2-...
Concept:
  • The base analogue of adenine called 2-aminopurine (2-AP) mispairs with cytosine and results in base-pair substitutions of the transition type.
  • The adenine base analog 2-aminopurine (2AP) is a potent base substitution mutagen in prokaryotes because of increased ability to form a mutagenic base pair with an incoming dCTP.
​Explanation:
  • Research studies confirmed that 2-AP induces both A:T leads to G:C and G:C leads to A:T transitions, with the former occurring more frequently than the latter.
  • These compounds result in DNA lesions when they are integrated into DNA.
  • These lesions will result in mutations if the mismatch correction system does not rectify the mismatches.
  • Normally, these lesions do not activate the SOS functions and act as miscoding lesions.
​​hence the correct answer is option 2
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Thymine and occasionally cytosine are paired with the base analogue 2-aminopurine base. The kind of mutation that this chemical causes is:a)deletionb)transitionc)transversiond)pointCorrect answer is option 'B'. Can you explain this answer?
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