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siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing.
A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer.
B. Drosha is needed for processing miRNAs and precursor siRNAs.
C. Both siRNAs and miRNAs show association with Argonaute protein.
D. Both the processing Pathways involves RISC complex
- a)A and C
- b)C and D
- c)A and B
- d)A and D
Correct answer is option 'C'. Can you explain this answer?
Verified Answer
siRNAs and miRNAs are used for achieving gene silencing. Although the ...
Concept:
- siRNAs and miRNAs share many similarities, both are short duplex RNA molecules that exert gene silencing effects at the post-transcriptional level by targeting messenger RNA (mRNA), yet their mechanisms of action and clinical applications are distinct.
- The major difference between siRNAs and miRNAs is that the former are highly specific with only one mRNA target, whereas the latter have multiple targets.
Explanation:
- A number of proteins help to mediate the influence of miRNAs and siRNAs on translation and mRNA decay, although the mechanisms by which they do so are, for the most part, unknown.
- Some of these proteins are thought to be integral components of the RNA-induced silencing complex (RISC) that delivers those small RNAs to complementary sites within mRNA, whereas others may associate with that complex only transiently if at all.
- The core subunit of RISC is the Argonaute protein Ago, which binds the mi/siRNA .
- In most species, this protein exists as multiple paralogs with distinct functions.
- At least one (e.g., Ago2 in humans, mice, and Drosophila) functions as an endonuclease able to cut mRNA within regions that are fully complementary to the mi/siRNA ,
- In addition, some Ago proteins (Ago1, Ago2, Ago3, and Ago4 in humans; Ago1 in Drosophila) appear capable of mediating both translational repression and accelerated deadenylation, as judged from the diminished regulatory potential of miRNAs and siRNAs when these proteins are depleted and from tethering experiments in which these proteins are bound to a reporter mRNA via a heterologous protein domain to which they are fused Other studies of this kind have demonstrated a role for
- Ago2 in miRNA-mediated translation activation in growth-arrested cell.
- Two other RISC components are Dicer and TRBP.
- Both are important for the production of miRNA and siRNA from precursor molecules, with Dicer functioning as the processing endonuclease and the RNA-binding protein TRBP serving as an ancillary factor
- However, only TRBP contributes to RISC function, as evidenced by the defect in RNA interference caused by depletion of that protein (but not Dicer) when synthetic, fully mature siRNAs are supplied by transfection.
hence the correct answer is option 3
Most Upvoted Answer
siRNAs and miRNAs are used for achieving gene silencing. Although the ...
Explanation:
Association with Argonaute protein:
- Both siRNAs and miRNAs show association with the Argonaute protein, which is a key component of the RNA-induced silencing complex (RISC).
- The Argonaute protein helps guide the siRNA or miRNA to the target mRNA, leading to gene silencing.
Therefore, option 'C' (A and C) is the correct answer.
Association with Argonaute protein:
- Both siRNAs and miRNAs show association with the Argonaute protein, which is a key component of the RNA-induced silencing complex (RISC).
- The Argonaute protein helps guide the siRNA or miRNA to the target mRNA, leading to gene silencing.
Therefore, option 'C' (A and C) is the correct answer.
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siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer?
Question Description
siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer?.
siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer? for Software Development 2025 is part of Software Development preparation. The Question and answers have been prepared according to the Software Development exam syllabus. Information about siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer? covers all topics & solutions for Software Development 2025 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer?.
Solutions for siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer? in English & in Hindi are available as part of our courses for Software Development.
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siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer?, a detailed solution for siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer? has been provided alongside types of siRNAs and miRNAs are used for achieving gene silencing. Although the major steps are similar, the key players in the two processing pathways differ significantly. The following statements are related to some of the characteristic features of gene silencing. A. Both siRNAs and miRNAs are processed by cytoplasmic and nuclease Dicer. B. Drosha is needed for processing miRNAs and precursor siRNAs. C. Both siRNAs and miRNAs show association with Argonaute protein. D. Both the processing Pathways involves RISC complexa)A and Cb)C and Dc)A and Bd)A and DCorrect answer is option 'C'. Can you explain this answer? theory, EduRev gives you an
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