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The Hofmann rearrangement has an intermediate that is electronically similar to that in the:
(1) Pinnacol rearrangement
(2) Claisen rearrangement
(3) Cope rearrangement
(4) Beckmann rearrangement?
(1) Pinnacol rearrangement
(2) Claisen rearrangement
(3) Cope rearrangement
(4) Beckmann rearrangement?
Most Upvoted Answer
The Hofmann rearrangement has an intermediate that is electronically s...
Hofmann rearrangement intermediate similarity
The intermediate in the Hofmann rearrangement is electronically similar to that in the Pinnacol rearrangement.
Explanation
- The Hofmann rearrangement involves the conversion of primary amides to primary amines through the migration of an alkyl group from the carbonyl carbon to the nitrogen atom. This process generates an isocyanate intermediate which then undergoes hydrolysis to form the primary amine.
- Similarly, in the Pinnacol rearrangement, a pinacol is converted into a ketone through a rearrangement process that involves the migration of an alkyl group between two carbon atoms. This rearrangement also generates an intermediate with a positively charged carbon atom, similar to the isocyanate intermediate in the Hofmann rearrangement.
- Both rearrangements involve the formation of a positively charged intermediate with a migrating alkyl group, making them electronically similar in nature.
Therefore, the intermediate in the Hofmann rearrangement is most similar to that in the Pinnacol rearrangement in terms of electronic properties and rearrangement mechanisms.
The intermediate in the Hofmann rearrangement is electronically similar to that in the Pinnacol rearrangement.
Explanation
- The Hofmann rearrangement involves the conversion of primary amides to primary amines through the migration of an alkyl group from the carbonyl carbon to the nitrogen atom. This process generates an isocyanate intermediate which then undergoes hydrolysis to form the primary amine.
- Similarly, in the Pinnacol rearrangement, a pinacol is converted into a ketone through a rearrangement process that involves the migration of an alkyl group between two carbon atoms. This rearrangement also generates an intermediate with a positively charged carbon atom, similar to the isocyanate intermediate in the Hofmann rearrangement.
- Both rearrangements involve the formation of a positively charged intermediate with a migrating alkyl group, making them electronically similar in nature.
Therefore, the intermediate in the Hofmann rearrangement is most similar to that in the Pinnacol rearrangement in terms of electronic properties and rearrangement mechanisms.
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The Hofmann rearrangement has an intermediate that is electronically similar to that in the:(1) Pinnacol rearrangement(2) Claisen rearrangement(3) Cope rearrangement(4) Beckmann rearrangement?
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The Hofmann rearrangement has an intermediate that is electronically similar to that in the:(1) Pinnacol rearrangement(2) Claisen rearrangement(3) Cope rearrangement(4) Beckmann rearrangement? for UGC NET 2024 is part of UGC NET preparation. The Question and answers have been prepared according to the UGC NET exam syllabus. Information about The Hofmann rearrangement has an intermediate that is electronically similar to that in the:(1) Pinnacol rearrangement(2) Claisen rearrangement(3) Cope rearrangement(4) Beckmann rearrangement? covers all topics & solutions for UGC NET 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for The Hofmann rearrangement has an intermediate that is electronically similar to that in the:(1) Pinnacol rearrangement(2) Claisen rearrangement(3) Cope rearrangement(4) Beckmann rearrangement?.
The Hofmann rearrangement has an intermediate that is electronically similar to that in the:(1) Pinnacol rearrangement(2) Claisen rearrangement(3) Cope rearrangement(4) Beckmann rearrangement? for UGC NET 2024 is part of UGC NET preparation. The Question and answers have been prepared according to the UGC NET exam syllabus. Information about The Hofmann rearrangement has an intermediate that is electronically similar to that in the:(1) Pinnacol rearrangement(2) Claisen rearrangement(3) Cope rearrangement(4) Beckmann rearrangement? covers all topics & solutions for UGC NET 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for The Hofmann rearrangement has an intermediate that is electronically similar to that in the:(1) Pinnacol rearrangement(2) Claisen rearrangement(3) Cope rearrangement(4) Beckmann rearrangement?.
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