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Reduction in pH of blood will [NEET 2016 Phase 1]
- a)Decrease the affinity of haemoglobin with oxygen.
- b)Release bicarbonate ions by the liver
- c)Reduce the rate of heartbeat
- d)Reduce the blood supply to the brain.
Correct answer is option 'A'. Can you explain this answer?
Most Upvoted Answer
Reduction in pH of blood will [NEET 2016 Phase 1]a)Decrease the aff...
- A reduction in blood pH indicates an increase in acidity, known as acidosis.
- Acidosis decreases hemoglobin's affinity for oxygen, meaning it releases oxygen more readily to the tissues.
- This is crucial for maintaining oxygen delivery, especially under stress or high metabolic activity.
- The other options, such as liver bicarbonate release and heart rate reduction, are not directly related to pH changes in blood.
- Thus, the correct answer is that reduced pH decreases hemoglobin's oxygen affinity.
- Acidosis decreases hemoglobin's affinity for oxygen, meaning it releases oxygen more readily to the tissues.
- This is crucial for maintaining oxygen delivery, especially under stress or high metabolic activity.
- The other options, such as liver bicarbonate release and heart rate reduction, are not directly related to pH changes in blood.
- Thus, the correct answer is that reduced pH decreases hemoglobin's oxygen affinity.
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Reduction in pH of blood will [NEET 2016 Phase 1]a)Decrease the aff...
Understanding Blood pH and Hemoglobin Affinity
The pH level of blood plays a crucial role in oxygen transport and delivery by hemoglobin. A reduction in blood pH indicates an increase in acidity, which significantly affects hemoglobin's ability to bind to oxygen.
Mechanism of pH Reduction
- A decrease in blood pH usually occurs in conditions like acidosis, where there is an accumulation of carbon dioxide (CO2) in the blood.
- This increase in CO2 leads to the formation of carbonic acid, which dissociates into bicarbonate and hydrogen ions, lowering the pH.
Effect on Hemoglobin
- The Bohr effect describes how decreased pH reduces hemoglobin's affinity for oxygen.
- With lower pH, hemoglobin undergoes a conformational change, promoting the release of oxygen to tissues.
- This is a physiological adaptation, as active tissues producing CO2 and acids need more oxygen for metabolism.
Consequences of Reduced Affinity
- As hemoglobin releases oxygen more readily, it ensures that oxygen delivery aligns with the metabolic needs of tissues, especially during strenuous activities.
- Therefore, a decrease in pH enhances oxygen unloading rather than binding.
Conclusion
In summary, a reduction in blood pH decreases the affinity of hemoglobin for oxygen, facilitating increased oxygen delivery where it is most needed. This physiological response underscores the importance of maintaining pH balance for optimal respiratory function.
Hence, the correct answer is option 'A'.
The pH level of blood plays a crucial role in oxygen transport and delivery by hemoglobin. A reduction in blood pH indicates an increase in acidity, which significantly affects hemoglobin's ability to bind to oxygen.
Mechanism of pH Reduction
- A decrease in blood pH usually occurs in conditions like acidosis, where there is an accumulation of carbon dioxide (CO2) in the blood.
- This increase in CO2 leads to the formation of carbonic acid, which dissociates into bicarbonate and hydrogen ions, lowering the pH.
Effect on Hemoglobin
- The Bohr effect describes how decreased pH reduces hemoglobin's affinity for oxygen.
- With lower pH, hemoglobin undergoes a conformational change, promoting the release of oxygen to tissues.
- This is a physiological adaptation, as active tissues producing CO2 and acids need more oxygen for metabolism.
Consequences of Reduced Affinity
- As hemoglobin releases oxygen more readily, it ensures that oxygen delivery aligns with the metabolic needs of tissues, especially during strenuous activities.
- Therefore, a decrease in pH enhances oxygen unloading rather than binding.
Conclusion
In summary, a reduction in blood pH decreases the affinity of hemoglobin for oxygen, facilitating increased oxygen delivery where it is most needed. This physiological response underscores the importance of maintaining pH balance for optimal respiratory function.
Hence, the correct answer is option 'A'.
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