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Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.
Q.
Which is used in cancer chemotherapy?
- a)cis-platin
- b)Zeise’s salt
- c)Ferrocene
- d)Fischer sal
Correct answer is option 'A'. Can you explain this answer?
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Verified Answer
Coordination compounds play a vital role in our lives. The importance ...
cis-dia m m inedichlo roplatin um (II), [cis[Pt(NH3)2CI2] is used in cancer chemotherapy.
The mechanism of cis-platin is based on Pt-DNA interaction. Platinum binds with N7 of two intrastrand adjacent guanine bases of DNA.
Their binding changes the active conformation of DNA leading to inhibiting of DNA replication or cell division.
cis -Pt(NH3)2CI2 + H2O .......cis - [Pt(NH3)2(OH)2CI]+ + Cl-
The hydrolysis reaction of cis-platin is an important aspect of the biological activity.
DNA coordinated trans complex begin to decrease after six hour whereas the cis-isomer is then accumulated in the cell nucleus.
The mechanism of cis-platin is based on Pt-DNA interaction. Platinum binds with N7 of two intrastrand adjacent guanine bases of DNA.
Their binding changes the active conformation of DNA leading to inhibiting of DNA replication or cell division.
cis -Pt(NH3)2CI2 + H2O .......cis - [Pt(NH3)2(OH)2CI]+ + Cl-
The hydrolysis reaction of cis-platin is an important aspect of the biological activity.
DNA coordinated trans complex begin to decrease after six hour whereas the cis-isomer is then accumulated in the cell nucleus.
Most Upvoted Answer
Coordination compounds play a vital role in our lives. The importance ...
Importance of Cis-Platin in Cancer Chemotherapy
Cis-platin, also known as cisplatin or cis-diamminedichloroplatinum(II), is a platinum-based coordination compound that has gained significance in cancer treatment.
Mechanism of Action
- Cis-platin works by forming DNA cross-links, which inhibit DNA replication and transcription.
- This mechanism triggers apoptosis (programmed cell death) in cancer cells, making it effective in treating various cancers.
Applications in Cancer Treatment
- Cis-platin is primarily used for treating testicular, ovarian, bladder, and lung cancers.
- It is often used in combination with other chemotherapy agents to enhance therapeutic effectiveness.
Advantages of Cis-Platin
- It has shown a high success rate in shrinking tumors and prolonging patient survival.
- Cis-platin's ability to target rapidly dividing cells makes it particularly effective against cancer.
Side Effects
- Despite its efficacy, cis-platin also has side effects, including nausea, vomiting, and potential damage to kidney function.
- Monitoring and supportive care are necessary to manage these side effects during treatment.
Conclusion
Cis-platin is a cornerstone in cancer chemotherapy due to its unique ability to interact with DNA, leading to effective cancer treatment. Its role in modern medicine highlights the importance of coordination compounds in addressing critical health challenges.
Cis-platin, also known as cisplatin or cis-diamminedichloroplatinum(II), is a platinum-based coordination compound that has gained significance in cancer treatment.
Mechanism of Action
- Cis-platin works by forming DNA cross-links, which inhibit DNA replication and transcription.
- This mechanism triggers apoptosis (programmed cell death) in cancer cells, making it effective in treating various cancers.
Applications in Cancer Treatment
- Cis-platin is primarily used for treating testicular, ovarian, bladder, and lung cancers.
- It is often used in combination with other chemotherapy agents to enhance therapeutic effectiveness.
Advantages of Cis-Platin
- It has shown a high success rate in shrinking tumors and prolonging patient survival.
- Cis-platin's ability to target rapidly dividing cells makes it particularly effective against cancer.
Side Effects
- Despite its efficacy, cis-platin also has side effects, including nausea, vomiting, and potential damage to kidney function.
- Monitoring and supportive care are necessary to manage these side effects during treatment.
Conclusion
Cis-platin is a cornerstone in cancer chemotherapy due to its unique ability to interact with DNA, leading to effective cancer treatment. Its role in modern medicine highlights the importance of coordination compounds in addressing critical health challenges.
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Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer?
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Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer? for Class 12 2024 is part of Class 12 preparation. The Question and answers have been prepared according to the Class 12 exam syllabus. Information about Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer? covers all topics & solutions for Class 12 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer?.
Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer? for Class 12 2024 is part of Class 12 preparation. The Question and answers have been prepared according to the Class 12 exam syllabus. Information about Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer? covers all topics & solutions for Class 12 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer?.
Solutions for Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer? in English & in Hindi are available as part of our courses for Class 12.
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Here you can find the meaning of Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer? defined & explained in the simplest way possible. Besides giving the explanation of
Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer?, a detailed solution for Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer? has been provided alongside types of Coordination compounds play a vital role in our lives. The importance of these compounds can be realised from the fact that life would not have been possible without the existence of chlorophyll in plants and haemoglobin in the blood of the animals. The field of such compounds has expanded very fast in recent years and coordination compounds are playing important roles in analytical chemistry, polymerisation reactions, metallurgy and refining of metals, etc.Q.Which is used in cancer chemotherapy?a)cis-platinb)Zeise’s saltc)Ferrocened)Fischer salCorrect answer is option 'A'. Can you explain this answer? theory, EduRev gives you an
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