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UNIT I: CHEMISTRY OF LIFE 
A. Elements 
? All life forms made up of matter 
? All matter made up of elements 
¦ Elements 
? Substances that cannot be broken down into smaller substances by 
chemical means 
B. Essential Elements of Life 
? 96% of the mass of all living things made up of 4 elements: 
? Oxygen (O) 
? Carbon (C)  
? Hydrogen (H) 
? Nitrogen (N) 
? Other elements (collectively 4% of biomass) 
? Calcium (Ca) 
? Phosphorus (P) 
? Potassium (K) 
? Sulfur (S) 
? Sodium (Na) 
? Chlorine (Cl) 
? Magnesium (Mg) 
? Trace elements 
? IRon (Fe) 
? Iodine (I) 
? Copper (Cu) 
C. Subatomic Particles 
? Atom 
? Smallest unit of an element 
? Building blocks of physical world 
? Subatomic PArticles 
? Protons 
¦ Packed with neutrons in nucleus 
¦ Positively charged 
¦ Most atoms have same amount of protons as electrons, making them electrically 
neutral 
? Neutrons 
¦ Packed with protons in nucleus 
¦ No charge 
¦ Isotopes 
? Same element with different amount of neutrons in nucleus 
? Vary in mass 
 
Page 2


   
UNIT I: CHEMISTRY OF LIFE 
A. Elements 
? All life forms made up of matter 
? All matter made up of elements 
¦ Elements 
? Substances that cannot be broken down into smaller substances by 
chemical means 
B. Essential Elements of Life 
? 96% of the mass of all living things made up of 4 elements: 
? Oxygen (O) 
? Carbon (C)  
? Hydrogen (H) 
? Nitrogen (N) 
? Other elements (collectively 4% of biomass) 
? Calcium (Ca) 
? Phosphorus (P) 
? Potassium (K) 
? Sulfur (S) 
? Sodium (Na) 
? Chlorine (Cl) 
? Magnesium (Mg) 
? Trace elements 
? IRon (Fe) 
? Iodine (I) 
? Copper (Cu) 
C. Subatomic Particles 
? Atom 
? Smallest unit of an element 
? Building blocks of physical world 
? Subatomic PArticles 
? Protons 
¦ Packed with neutrons in nucleus 
¦ Positively charged 
¦ Most atoms have same amount of protons as electrons, making them electrically 
neutral 
? Neutrons 
¦ Packed with protons in nucleus 
¦ No charge 
¦ Isotopes 
? Same element with different amount of neutrons in nucleus 
? Vary in mass 
 
? Radioactive isotopes decay spontaneously, giving off particles and 
energy 
? Electrons 
¦ Negatively charged 
¦ Spin around nucleus 
¦ Very small; effectively massless 
¦ Electrons on an atom differ in their amounts of potential energy 
¦ Electron’s state of potential energy is called its energy level, or electron shell 
¦ Valence electrons are those in the outermost shell, or valence shell 
¦ Chemical behavior of an atom is mostly determined by the distribution of 
electrons in electron shells 
? Valence shell most important 
? Elements with full valence shells are chemically inert  
? Atoms with incomplete valence shells can share or transfer valence 
electrons with certain other atoms 
? Atoms of different various elements differ in number of subatomic particles 
? Atomic number=#protons in nucleus 
? Mass Number= protons+neutrons 
¦ Average of all isotopes 
? Atomic mass+atom’s weighted average total mass 
 
D. Compounds 
? Compound occurs as result of 2 or more individual elements combining in a fixed ratio  
? Different properties of individual elements 
? Formed by chemical reaction  
? Bonds that hold compounds together 
? Ionic bonds 
¦ nonmetal+metal 
¦ One or more electrons is transferred from one atom to another 
¦ One atom loses electrons (becomes positively charged) while the other gains 
electrons (becomes negatively charged) 
¦ Results from attraction of two oppositely charged ions 
 
Page 3


   
UNIT I: CHEMISTRY OF LIFE 
A. Elements 
? All life forms made up of matter 
? All matter made up of elements 
¦ Elements 
? Substances that cannot be broken down into smaller substances by 
chemical means 
B. Essential Elements of Life 
? 96% of the mass of all living things made up of 4 elements: 
? Oxygen (O) 
? Carbon (C)  
? Hydrogen (H) 
? Nitrogen (N) 
? Other elements (collectively 4% of biomass) 
? Calcium (Ca) 
? Phosphorus (P) 
? Potassium (K) 
? Sulfur (S) 
? Sodium (Na) 
? Chlorine (Cl) 
? Magnesium (Mg) 
? Trace elements 
? IRon (Fe) 
? Iodine (I) 
? Copper (Cu) 
C. Subatomic Particles 
? Atom 
? Smallest unit of an element 
? Building blocks of physical world 
? Subatomic PArticles 
? Protons 
¦ Packed with neutrons in nucleus 
¦ Positively charged 
¦ Most atoms have same amount of protons as electrons, making them electrically 
neutral 
? Neutrons 
¦ Packed with protons in nucleus 
¦ No charge 
¦ Isotopes 
? Same element with different amount of neutrons in nucleus 
? Vary in mass 
 
? Radioactive isotopes decay spontaneously, giving off particles and 
energy 
? Electrons 
¦ Negatively charged 
¦ Spin around nucleus 
¦ Very small; effectively massless 
¦ Electrons on an atom differ in their amounts of potential energy 
¦ Electron’s state of potential energy is called its energy level, or electron shell 
¦ Valence electrons are those in the outermost shell, or valence shell 
¦ Chemical behavior of an atom is mostly determined by the distribution of 
electrons in electron shells 
? Valence shell most important 
? Elements with full valence shells are chemically inert  
? Atoms with incomplete valence shells can share or transfer valence 
electrons with certain other atoms 
? Atoms of different various elements differ in number of subatomic particles 
? Atomic number=#protons in nucleus 
? Mass Number= protons+neutrons 
¦ Average of all isotopes 
? Atomic mass+atom’s weighted average total mass 
 
D. Compounds 
? Compound occurs as result of 2 or more individual elements combining in a fixed ratio  
? Different properties of individual elements 
? Formed by chemical reaction  
? Bonds that hold compounds together 
? Ionic bonds 
¦ nonmetal+metal 
¦ One or more electrons is transferred from one atom to another 
¦ One atom loses electrons (becomes positively charged) while the other gains 
electrons (becomes negatively charged) 
¦ Results from attraction of two oppositely charged ions 
 
¦ Cation has a positive charge 
¦ Anion has a negative charge 
¦ Cation and anion form to create ionic bond 
? Covalent bonds 
¦ nonmetal+nonmetal 
¦ Molecule consists of 2 or more atoms held together by covalent bonds 
¦ Formed when electrons are shared between atoms 
¦ In nonpolar covalent bond, electrons are shared equally 
¦ In polar covalent bond, electrons are shared unequally 
¦ In a single covalent bond, one pair of electrons is shared 
? Double covalent when 2 pairs are shared, etc.  
¦ Structural formula used to represent atoms and bonding 
? Ex. H-H 
¦ Molecular formula abbreviates structural formula 
? Ex. H
2
 
? Electronegativity is an atom’s attraction for the atoms in a covalent 
bond 
? The more electronegative an atom, the more strongly it pulls 
shared electrons toward itself 
? Hydrogen bonds 
¦ Hydrogen atom covalently bonds to one electronegative ato is also attracted to 
another electronegative atom 
¦ In living cells, hydrogen bonds are usually oxygen or other nitrogen atoms 
? Van der Waals Interactions 
¦ Weakest 
¦ If electrons are distributed asymmetrically in molecules or atoms, they can result 
in “hot spots” of positive or negative charge 
¦ Attractions between molecules that are close together as a result of these charges 
? How geckos climb 
E. Water: The Versatile Molecule 
? In water, electrons are not shared equally in the bonds between hydrogen and oxygen 
? Hydrogen atoms have a partial positive charge while oxygen atoms has a partial negative 
charge 
¦ Water is polar 
 
Page 4


   
UNIT I: CHEMISTRY OF LIFE 
A. Elements 
? All life forms made up of matter 
? All matter made up of elements 
¦ Elements 
? Substances that cannot be broken down into smaller substances by 
chemical means 
B. Essential Elements of Life 
? 96% of the mass of all living things made up of 4 elements: 
? Oxygen (O) 
? Carbon (C)  
? Hydrogen (H) 
? Nitrogen (N) 
? Other elements (collectively 4% of biomass) 
? Calcium (Ca) 
? Phosphorus (P) 
? Potassium (K) 
? Sulfur (S) 
? Sodium (Na) 
? Chlorine (Cl) 
? Magnesium (Mg) 
? Trace elements 
? IRon (Fe) 
? Iodine (I) 
? Copper (Cu) 
C. Subatomic Particles 
? Atom 
? Smallest unit of an element 
? Building blocks of physical world 
? Subatomic PArticles 
? Protons 
¦ Packed with neutrons in nucleus 
¦ Positively charged 
¦ Most atoms have same amount of protons as electrons, making them electrically 
neutral 
? Neutrons 
¦ Packed with protons in nucleus 
¦ No charge 
¦ Isotopes 
? Same element with different amount of neutrons in nucleus 
? Vary in mass 
 
? Radioactive isotopes decay spontaneously, giving off particles and 
energy 
? Electrons 
¦ Negatively charged 
¦ Spin around nucleus 
¦ Very small; effectively massless 
¦ Electrons on an atom differ in their amounts of potential energy 
¦ Electron’s state of potential energy is called its energy level, or electron shell 
¦ Valence electrons are those in the outermost shell, or valence shell 
¦ Chemical behavior of an atom is mostly determined by the distribution of 
electrons in electron shells 
? Valence shell most important 
? Elements with full valence shells are chemically inert  
? Atoms with incomplete valence shells can share or transfer valence 
electrons with certain other atoms 
? Atoms of different various elements differ in number of subatomic particles 
? Atomic number=#protons in nucleus 
? Mass Number= protons+neutrons 
¦ Average of all isotopes 
? Atomic mass+atom’s weighted average total mass 
 
D. Compounds 
? Compound occurs as result of 2 or more individual elements combining in a fixed ratio  
? Different properties of individual elements 
? Formed by chemical reaction  
? Bonds that hold compounds together 
? Ionic bonds 
¦ nonmetal+metal 
¦ One or more electrons is transferred from one atom to another 
¦ One atom loses electrons (becomes positively charged) while the other gains 
electrons (becomes negatively charged) 
¦ Results from attraction of two oppositely charged ions 
 
¦ Cation has a positive charge 
¦ Anion has a negative charge 
¦ Cation and anion form to create ionic bond 
? Covalent bonds 
¦ nonmetal+nonmetal 
¦ Molecule consists of 2 or more atoms held together by covalent bonds 
¦ Formed when electrons are shared between atoms 
¦ In nonpolar covalent bond, electrons are shared equally 
¦ In polar covalent bond, electrons are shared unequally 
¦ In a single covalent bond, one pair of electrons is shared 
? Double covalent when 2 pairs are shared, etc.  
¦ Structural formula used to represent atoms and bonding 
? Ex. H-H 
¦ Molecular formula abbreviates structural formula 
? Ex. H
2
 
? Electronegativity is an atom’s attraction for the atoms in a covalent 
bond 
? The more electronegative an atom, the more strongly it pulls 
shared electrons toward itself 
? Hydrogen bonds 
¦ Hydrogen atom covalently bonds to one electronegative ato is also attracted to 
another electronegative atom 
¦ In living cells, hydrogen bonds are usually oxygen or other nitrogen atoms 
? Van der Waals Interactions 
¦ Weakest 
¦ If electrons are distributed asymmetrically in molecules or atoms, they can result 
in “hot spots” of positive or negative charge 
¦ Attractions between molecules that are close together as a result of these charges 
? How geckos climb 
E. Water: The Versatile Molecule 
? In water, electrons are not shared equally in the bonds between hydrogen and oxygen 
? Hydrogen atoms have a partial positive charge while oxygen atoms has a partial negative 
charge 
¦ Water is polar 
 
 
? Hydrogen bonds 
? Weak attractions that result of water’s polarity 
¦ Positive end of another polar molecule attracted to oxygen negative charge, and 
vice versa with the hydrogen end 
¦ Hydrogen atom covalently bonded to one electronegative atom is also attracted to 
another electronegative atom 
¦ Weak Individually, but strong on a larger scale 
? Lends watermany special properties 
¦ Cohesion 
? Tendency for water to stick to water 
? Important during transpiration 
? Water evaporates, pulls other water molecules with it, pulling all 
the way down from leaves to roots 
¦ Adhesion 
? Tendency of water to stick to other substances 
? Cohesion + Adhesion = capillary action 
? Allows water to flow up roots/trunks/branches of trees in thin 
vessels 
¦ Surface tension 
? Results from cohesion of water molecules 
? Ex. water striders can sit on top of water without sinking 
¦ High heat capacity 
? Heat CApacity=ability of a substance to resist temperature changes 
? Keeps ocean temperatures stable 
? Allows organisms to keep constant body temperature, since most life 
forms are mostly made up of water 
? Heat is absorbed  when hydrogen bonds break, released when hydrogen 
bonds form 
¦ High heat of vaporization 
? Heat a liquid must absorb for 1g to be converted to gas 
 
Page 5


   
UNIT I: CHEMISTRY OF LIFE 
A. Elements 
? All life forms made up of matter 
? All matter made up of elements 
¦ Elements 
? Substances that cannot be broken down into smaller substances by 
chemical means 
B. Essential Elements of Life 
? 96% of the mass of all living things made up of 4 elements: 
? Oxygen (O) 
? Carbon (C)  
? Hydrogen (H) 
? Nitrogen (N) 
? Other elements (collectively 4% of biomass) 
? Calcium (Ca) 
? Phosphorus (P) 
? Potassium (K) 
? Sulfur (S) 
? Sodium (Na) 
? Chlorine (Cl) 
? Magnesium (Mg) 
? Trace elements 
? IRon (Fe) 
? Iodine (I) 
? Copper (Cu) 
C. Subatomic Particles 
? Atom 
? Smallest unit of an element 
? Building blocks of physical world 
? Subatomic PArticles 
? Protons 
¦ Packed with neutrons in nucleus 
¦ Positively charged 
¦ Most atoms have same amount of protons as electrons, making them electrically 
neutral 
? Neutrons 
¦ Packed with protons in nucleus 
¦ No charge 
¦ Isotopes 
? Same element with different amount of neutrons in nucleus 
? Vary in mass 
 
? Radioactive isotopes decay spontaneously, giving off particles and 
energy 
? Electrons 
¦ Negatively charged 
¦ Spin around nucleus 
¦ Very small; effectively massless 
¦ Electrons on an atom differ in their amounts of potential energy 
¦ Electron’s state of potential energy is called its energy level, or electron shell 
¦ Valence electrons are those in the outermost shell, or valence shell 
¦ Chemical behavior of an atom is mostly determined by the distribution of 
electrons in electron shells 
? Valence shell most important 
? Elements with full valence shells are chemically inert  
? Atoms with incomplete valence shells can share or transfer valence 
electrons with certain other atoms 
? Atoms of different various elements differ in number of subatomic particles 
? Atomic number=#protons in nucleus 
? Mass Number= protons+neutrons 
¦ Average of all isotopes 
? Atomic mass+atom’s weighted average total mass 
 
D. Compounds 
? Compound occurs as result of 2 or more individual elements combining in a fixed ratio  
? Different properties of individual elements 
? Formed by chemical reaction  
? Bonds that hold compounds together 
? Ionic bonds 
¦ nonmetal+metal 
¦ One or more electrons is transferred from one atom to another 
¦ One atom loses electrons (becomes positively charged) while the other gains 
electrons (becomes negatively charged) 
¦ Results from attraction of two oppositely charged ions 
 
¦ Cation has a positive charge 
¦ Anion has a negative charge 
¦ Cation and anion form to create ionic bond 
? Covalent bonds 
¦ nonmetal+nonmetal 
¦ Molecule consists of 2 or more atoms held together by covalent bonds 
¦ Formed when electrons are shared between atoms 
¦ In nonpolar covalent bond, electrons are shared equally 
¦ In polar covalent bond, electrons are shared unequally 
¦ In a single covalent bond, one pair of electrons is shared 
? Double covalent when 2 pairs are shared, etc.  
¦ Structural formula used to represent atoms and bonding 
? Ex. H-H 
¦ Molecular formula abbreviates structural formula 
? Ex. H
2
 
? Electronegativity is an atom’s attraction for the atoms in a covalent 
bond 
? The more electronegative an atom, the more strongly it pulls 
shared electrons toward itself 
? Hydrogen bonds 
¦ Hydrogen atom covalently bonds to one electronegative ato is also attracted to 
another electronegative atom 
¦ In living cells, hydrogen bonds are usually oxygen or other nitrogen atoms 
? Van der Waals Interactions 
¦ Weakest 
¦ If electrons are distributed asymmetrically in molecules or atoms, they can result 
in “hot spots” of positive or negative charge 
¦ Attractions between molecules that are close together as a result of these charges 
? How geckos climb 
E. Water: The Versatile Molecule 
? In water, electrons are not shared equally in the bonds between hydrogen and oxygen 
? Hydrogen atoms have a partial positive charge while oxygen atoms has a partial negative 
charge 
¦ Water is polar 
 
 
? Hydrogen bonds 
? Weak attractions that result of water’s polarity 
¦ Positive end of another polar molecule attracted to oxygen negative charge, and 
vice versa with the hydrogen end 
¦ Hydrogen atom covalently bonded to one electronegative atom is also attracted to 
another electronegative atom 
¦ Weak Individually, but strong on a larger scale 
? Lends watermany special properties 
¦ Cohesion 
? Tendency for water to stick to water 
? Important during transpiration 
? Water evaporates, pulls other water molecules with it, pulling all 
the way down from leaves to roots 
¦ Adhesion 
? Tendency of water to stick to other substances 
? Cohesion + Adhesion = capillary action 
? Allows water to flow up roots/trunks/branches of trees in thin 
vessels 
¦ Surface tension 
? Results from cohesion of water molecules 
? Ex. water striders can sit on top of water without sinking 
¦ High heat capacity 
? Heat CApacity=ability of a substance to resist temperature changes 
? Keeps ocean temperatures stable 
? Allows organisms to keep constant body temperature, since most life 
forms are mostly made up of water 
? Heat is absorbed  when hydrogen bonds break, released when hydrogen 
bonds form 
¦ High heat of vaporization 
? Heat a liquid must absorb for 1g to be converted to gas 
 
? Evaporative cooling 
? As a liquid evaporates, its remaining surface cools 
¦ How sweat works to cool body down 
¦ Expansion on freezing 
? Lattice structure of ice causes water to expand on freezing 
? Allows ice to float on top of lakes in winter 
? Animal life can live beneath ice 
¦ Versatility as a solvent 
? Solution is a liquid that is a homogenous mix of substances 
? Solvent is the dissolving agent of a solution 
? Solute is the substance that is dissolved 
? Aqueous solution is one where water is the solvent 
? Polarity of water allows it to be a versatile solvent 
? Can form hydrogen bonds easily 
? Hydrophobic substances do not dissolve in water, but hydrophilic ones 
will 
F. Acids and Bases 
? Solution is acidic if it contains a lot of H
+
  
? Solution is alkaline if it contains a lot of OH
-
 
? Measured on pH scale 
? Logarithmic 
? Numbered 1-14 
¦ Acids 1-7 pH 
¦ Bases 7-14 pH 
? Buffers maintain stable pH 
G. Organic Molecules 
?  Organic compound contains Carbon 
? Inorganic compound does not contain carbon 
? Carbon often surrounded by hydrogen 
? Carbon is a versatile atom 
? Can bind with many elements 
? Many “slots” to bind with elements 
¦ 4 valence electrons  
? Can form 4 covalent bonds 
¦ Makes large, complex molecules possible 
? In molecules with multiple carbons, each carbon bonded to 4 other atoms has a 
tetrahedral shape 
¦ When 2 carbons are formed by a double bond, the atoms joined to the carbons are 
one the same plane as the carbons 
? Electron configuration gives it covalent compatibility with other elements 
? Hydrocarbons consist of only carbon and hydrogen 
¦ Can undergo reactions that release a large amount of energy 
 
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FAQs on Cheatsheet: Chemistry of Life - AP Biology - Grade 9

1. What are the basic building blocks of life?
Ans. The basic building blocks of life are cells. Cells are the smallest unit of life and are classified into two main types: prokaryotic cells, which lack a nucleus (like bacteria), and eukaryotic cells, which have a nucleus and organelles (like plant and animal cells). These cells come together to form tissues, organs, and ultimately, entire organisms.
2. What role do carbohydrates play in the chemistry of life?
Ans. Carbohydrates are essential macromolecules that provide energy for living organisms. They are composed of carbon, hydrogen, and oxygen in a ratio of 1:2:1. Simple carbohydrates, like glucose (C₆H₁₂O₆), are quick sources of energy, while complex carbohydrates, such as starch and cellulose, serve as energy storage and structural components in plants.
3. How do proteins contribute to biological functions?
Ans. Proteins are made of amino acids and play a crucial role in nearly every biological process. They serve as enzymes to speed up chemical reactions, provide structure to cells and tissues, transport molecules, and regulate biological processes. The sequence and arrangement of amino acids in a protein determine its specific function.
4. What is the significance of nucleic acids in living organisms?
Ans. Nucleic acids, such as DNA and RNA, are vital for storing and transmitting genetic information. DNA (deoxyribonucleic acid) contains the instructions for building proteins and is responsible for heredity, while RNA (ribonucleic acid) plays a key role in translating these instructions into proteins. Together, they ensure the continuity of life and the proper functioning of cells.
5. How do enzymes function in biochemical reactions?
Ans. Enzymes are biological catalysts that speed up chemical reactions in living organisms without being consumed in the process. They lower the activation energy required for reactions to occur, allowing them to proceed more quickly and efficiently. Each enzyme is specific to a particular substrate, which binds to the enzyme's active site, facilitating the conversion of reactants to products.
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