UPSC Exam > UPSC Notes > Chemistry Optional Notes for UPSC > Fischer indole synthesis
Fischer indole synthesis | Chemistry Optional Notes for UPSC PDF Download
Definition: What is Fischer Indole Synthesis?
The Fischer indole synthesis is an organic reaction used to convert a phenylhydrazine and an aldehyde or ketone to an indole using an acid catalyst, like Brønsted or Lewis acids. An application of this reaction is the synthesis of antimigraine drugs belonging to the triptan class.
The history of this reaction goes back to 1883 when the reaction was first discovered by a German chemist Emil Fischer.
Examples of Fischer Indole Synthesis
The Fisher indole synthesis is used to synthesize 2-phenylindole and tetrahydrocarbazole.
Mechanism of Fischer Indole Synthesis
Phenylhydrazone is formed from a condensation reaction of phenylhydrazine and an aldehyde or ketone. The phenylhydrazone converts into an indole in the presence of an acid catalyst.
Question for Fischer indole synthesisTry yourself: What is the purpose of Fischer indole synthesis?View Solution
The document Fischer indole synthesis | Chemistry Optional Notes for UPSC is a part of the UPSC Course Chemistry Optional Notes for UPSC.
All you need of UPSC at this link: UPSC
FAQs on Fischer indole synthesis - Chemistry Optional Notes for UPSC
| 1. What is Fischer Indole Synthesis? |  |
Ans. Fischer Indole Synthesis is a chemical reaction used to synthesize indole compounds. It involves the cyclization of an aryl hydrazine and a carbonyl compound, typically an aldehyde or ketone, in the presence of an acid catalyst. The reaction proceeds through the formation of a reactive imine intermediate, which undergoes intramolecular cyclization to form the indole ring.
| 2. What are some examples of Fischer Indole Synthesis? | |
Ans. Some examples of Fischer Indole Synthesis include the synthesis of indole-3-carboxaldehyde from hydrazine hydrate and isatin, the synthesis of 2-phenylindole from acetophenone and phenylhydrazine, and the synthesis of 5-methylindole from 2-methylbenzaldehyde and methylhydrazine.
| 3. What is the mechanism of Fischer Indole Synthesis? | |
Ans. The mechanism of Fischer Indole Synthesis involves several steps. Firstly, the aryl hydrazine and carbonyl compound react to form an imine intermediate. This reaction is catalyzed by an acid, such as sulfuric acid. The imine then undergoes intramolecular cyclization, forming a five-membered imine intermediate. This intermediate tautomerizes to the final indole product through a series of proton transfers and rearrangements.
| 4. What are the key reagents and conditions required for Fischer Indole Synthesis? | |
Ans. The key reagents required for Fischer Indole Synthesis are an aryl hydrazine, a carbonyl compound (aldehyde or ketone), and an acid catalyst. Commonly used acid catalysts include sulfuric acid, hydrochloric acid, and phosphoric acid. The reaction is typically carried out at elevated temperatures, often under reflux conditions.
| 5. What are the applications of Fischer Indole Synthesis? | |
Ans. Fischer Indole Synthesis is widely used in organic synthesis to access various indole derivatives, which have diverse biological activities and pharmaceutical applications. Indole compounds are found in many natural products and can serve as building blocks for the synthesis of complex molecules. They are often utilized in medicinal chemistry for the development of drugs targeting a variety of diseases, including cancer, neurological disorders, and infectious diseases.
Related Exams
About this Document
|
Dec 31, 2024 Last updated |
Document Description: Fischer indole synthesis for UPSC 2024 is part of Chemistry Optional Notes for UPSC preparation.
The notes and questions for Fischer indole synthesis have been prepared according to the UPSC exam syllabus. Information about Fischer indole synthesis covers topics
like Definition: What is Fischer Indole Synthesis?, Examples of Fischer Indole Synthesis, Mechanism of Fischer Indole Synthesis and Fischer indole synthesis Example, for UPSC 2024 Exam. Find important definitions, questions, notes, meanings, examples, exercises and tests below for Fischer indole synthesis.
Introduction of Fischer indole synthesis in English is available as part of our Chemistry Optional Notes for UPSC
for UPSC & Fischer indole synthesis in Hindi for Chemistry Optional Notes for UPSC course.
Download more important topics related with notes, lectures and mock test series for UPSC
Exam by signing up for free. UPSC: Fischer indole synthesis | Chemistry Optional Notes for UPSC
Description
Full syllabus notes, lecture & questions for Fischer indole synthesis | Chemistry Optional Notes for UPSC - UPSC | Plus excerises question with solution to help you revise complete syllabus for Chemistry Optional Notes for UPSC | Best notes, free PDF download
Information about Fischer indole synthesis
In this doc you can find the meaning of Fischer indole synthesis defined & explained in the simplest way possible. Besides explaining types of
Fischer indole synthesis theory, EduRev gives you an ample number of questions to practice Fischer indole synthesis tests, examples and also practice UPSC
tests
|
Explore Courses for UPSC exam
|
|
Signup for Free!
Signup to see your scores go up within 7 days! Learn & Practice with 1000+ FREE Notes, Videos & Tests.
Related Searches
Exam
,Previous Year Questions with Solutions
,MCQs
,Free
,video lectures
,Viva Questions
,shortcuts and tricks
,Fischer indole synthesis | Chemistry Optional Notes for UPSC
,mock tests for examination
,Sample Paper
,ppt
,Extra Questions
,past year papers
,Objective type Questions
,Important questions
,Fischer indole synthesis | Chemistry Optional Notes for UPSC
,practice quizzes
,Fischer indole synthesis | Chemistry Optional Notes for UPSC
,Semester Notes
,Summary
,study material
;
Additional Information about Fischer indole synthesis for UPSC Preparation
Fischer indole synthesis Free PDF Download
The Fischer indole synthesis is an invaluable resource that delves deep into the core of the UPSC exam.
These study notes are curated by experts and cover all the essential topics and concepts, making your preparation more efficient and effective.
With the help of these notes, you can grasp complex subjects quickly, revise important points easily,
and reinforce your understanding of key concepts. The study notes are presented in a concise and easy-to-understand manner,
allowing you to optimize your learning process. Whether you're looking for best-recommended books, sample papers, study material,
or toppers' notes, this PDF has got you covered. Download the Fischer indole synthesis now and kickstart your journey towards success in the UPSC exam.
Importance of Fischer indole synthesis
The importance of Fischer indole synthesis cannot be overstated, especially for UPSC aspirants.
This document holds the key to success in the UPSC exam.
It offers a detailed understanding of the concept, providing invaluable insights into the topic.
By knowing the concepts well in advance, students can plan their preparation effectively.
Utilize this indispensable guide for a well-rounded preparation and achieve your desired results.
Fischer indole synthesis Notes
Fischer indole synthesis Notes offer in-depth insights into the specific topic to help you master it with ease.
This comprehensive document covers all aspects related to Fischer indole synthesis.
It includes detailed information about the exam syllabus, recommended books, and study materials for a well-rounded preparation.
Practice papers and question papers enable you to assess your progress effectively.
Additionally, the paper analysis provides valuable tips for tackling the exam strategically.
Access to Toppers' notes gives you an edge in understanding complex concepts.
Whether you're a beginner or aiming for advanced proficiency, Fischer indole synthesis Notes on EduRev are your ultimate resource for success.
Fischer indole synthesis UPSC Questions
The "Fischer indole synthesis UPSC Questions" guide is a valuable resource for all aspiring students preparing for the
UPSC exam. It focuses on providing a wide range of practice questions to help students gauge
their understanding of the exam topics. These questions cover the entire syllabus, ensuring comprehensive preparation.
The guide includes previous years' question papers for students to familiarize themselves with the exam's format and difficulty level.
Additionally, it offers subject-specific question banks, allowing students to focus on weak areas and improve their performance.
Study Fischer indole synthesis on the App
Students of UPSC can study Fischer indole synthesis alongwith tests & analysis from the EduRev app,
which will help them while preparing for their exam. Apart from the Fischer indole synthesis,
students can also utilize the EduRev App for other study materials such as previous year question papers, syllabus, important questions, etc.
The EduRev App will make your learning easier as you can access it from anywhere you want.
The content of Fischer indole synthesis is prepared as per the latest UPSC syllabus.
|
© EduRev
|
Education Revolution
|
|
Signup to see your scores
go up within 7 days!
Access 1000+ FREE Docs, Videos and Tests
Takes less than 10 seconds to signup