Reaction of Amines with aryl sulfonyl chloride Video Lecture - NEET

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reaction of a mean with early heights
now ever me I will react with already
high so let's suppose this is my typical
amine here and we act with aldehyde my
aldehyde is our - co h so what happens
here is this h2 will react this what
rule out and what you get is RN double
bond c with h and r - and this is schiff
base correct so please note this is only
the primary amine because you need to
hydrogen
this has to be primary amine primary
amine will react with aldehyde to form
ship base and you can further reduce
this to a secondary amine Ashley so this
becomes R in h CH 2 or - if you add
hydrogen it becomes our wrench CH Nisus
you see the secondary MV correct so this
reaction of amine with Rd ID is only for
the primary amine because you should
have two hydrogen's correct and then
whatever output you get you can actually
is called shift base you can do a
reduction for this to convert this to a
2 D really let's see the reaction
mechanism for this I have our n h2 the
double bond here and I have R - co h
slightly negative slightly positives
won't be able to add this carbon so with
this I get our n h h c o- h n car - so
here since the nitrogen has given
on this column I cleaned it was a
positive charge somebody has to leave
this hydrogen is goodly we grew Italy as
H+ right this becomes R and H in this S
Plus will come and attack this oxygen
you get Co H R - H correct
now again will be H + that will attack
this oxygen it will become h2o plus s 2
plus is too heavy then so this will
become h2o plus this too heavy
so this h2o will go off carbon will get
a positive charge
now since carbon got a positive charge
somebody has to go if hydrogen goes
carbonated only 2 bonds that is not good
carbon eats four gone so what will
happen is this nitrogen will see ok I
will keep this hydrogen off hydrogen
goes off nitrogen that's a negative
charge negative and positive forms a
bond you get on and that we won't see h
garnished and this is if you see is my
base and on this you can do
hydrogenation so this bond will break
and one hydrogen will adhere one
hydrogen will adhere and you will get
this all right let's see the reaction
with Orion's sulfonyl chloride let's now
see the reaction of amine with a rile
sulfonyl chloride let's take one example
of arise of pellagra is benzene circle
and chloride this is my benzene
sulfonate cry also called his birth
reagent
so this will react with one degree or
two degree Amin to form sulfonamides
please note to react only with one
degree in 2 degree me not with 3 because
it needs some hydrogen trivia I'll take
the reaction of a 2 degree actually 1
degree I mean it's done with this so I
have this when react with 1 degree I
mean c2h5 n is 2 here so what will
happen is this H and this CL will come
out and you will get an edge C to H way
and SC will come on this called this is
n ethyl is the option group benzene
sulfonamides that is the name of this
compound right so this H is actually
strongly acid and this is a soluble
alkie there is a electron withdrawing
group this becomes little acetic so now
if you want to see the reaction
mechanism the reaction mechanism is this
so I have this sulfonyl Araya sulfonyl
chloride sulfur as always electron
hungry and I have this nitrogen with a
lone pair of electrons nitrogen will do
what it is attack this sulfur and the
sulfur right and then it will be
negative charge here and what you get
is this Oh - this the chlorine here and
then I have an N here hydrogen here
hydrogen here n c2 H right here since my
Trojan is giving electrons to sulfur
nitrogen is a positive charge now what
will happen is this oxygen gets negative
charge it will revert back and chlorine
will come out also the nitrogen has a
positive charge somebody has to come out
hydrogen will come out so with this what
you get is this comma C well nitrogen
has positive charge there has to be some
hydrogen to come out right so this
happens only for primary and secondary
mean this is vast finally I mean it has
two hydrogen 1 hydrogen ki-moon and you
got this as the product let's do the
similar reaction for secondary amine I
have my this one Bin's i'll sulfonyl
chloride then react with secondary amine
here correct so this will give me what
this will give me this row and this H
and this CL will go up n c2 H Phi and C
2 H right so reaction mechanism begin to
the simpler one which I have done in the
last slide or if you want I can draw it
for you CL this nitrogen with a lone
pair of electron will be attracted
towards this sulfur go up in this
direction this negative charge
so what would happen is the product you
get is something like this negative
charge double bond is the seal here
there is a nitrogen here with one
hydrogen one myth
and the thigh pro since nitrogen gave
electron to the sulfur nitrogen it's a
politician so this oxygen will go in
this direction this electron will go in
this direction or even come out nitrogen
bond to get rid of this hydrogen Bostaph
charge actually so to get rid of this
position some buddy has to go this
hydrogen will go in this direction so
what you get is this this is what you
correct this is so if you see this
happens only for one degree and Tuli
correct for three degree this reaction
goes in half this property is also used
to distinguish three degree from one
degree in two days so you have three
compounds one day D 2 D 3 D I have to
find which one is 3 degree compound or
which one is tertiary amine so in that
case I can use this reaction
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