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The type of petrification in which the organic matter of the dead body is replaced by double carbonates of calcium and magnesium is called
  • a)
    Silicification
  • b)
    Pyritization
  • c)
    Carbonization
  • d)
    Dolomitization
  • e)
    None of these
Correct answer is option 'D'. Can you explain this answer?

Ayesha Joshi answered
During the process of fossil formation, petrification occurs when dissolved minerals replace the organic remains of deceased organisms. Petrification takes on different forms depending on the specific mineral involved. Silicification, for example, entails the substitution of original organic matter with silica. Pyritization, on the other hand, involves the replacement of organic material with iron pyrites. Carbonization refers to the deposition of carbon compounds, while in dolomitization, magnesium carbonate replaces previously deposited calcium carbonate within the decaying organic matter.

The semi fluid mass of partly digested food is called chyme. Formation of chyme takes place in
  • a)
    Mouth
  • b)
    Small intestine
  • c)
    Large intestine
  • d)
    Liver
  • e)
    Stomach
Correct answer is option 'E'. Can you explain this answer?

Hazel Hill answered
Understanding Chyme Formation
Chyme is a semi-fluid mass of partly digested food that plays a crucial role in the digestive process. Its formation is primarily associated with the stomach. Here’s a detailed explanation:
Where Chyme is Formed
- Stomach: The formation of chyme occurs in the stomach, where food is mixed with gastric juices. This combination breaks down food particles into a semi-liquid state.

The Process of Chyme Formation
- Ingestion: After food is ingested in the mouth, it is chewed and mixed with saliva to form a bolus.
- Esophagus: The bolus travels down the esophagus to the stomach via peristalsis.
- Gastric Juices: In the stomach, gastric glands secrete hydrochloric acid and digestive enzymes (like pepsin) that further break down proteins and kill pathogens.
- Mechanical Mixing: The stomach muscles churn the food, mixing it with these gastric juices to form chyme.
Importance of Chyme
- Nutrient Absorption: Chyme is crucial for nutrient absorption. Once formed, it gradually moves into the small intestine, where further digestion and nutrient absorption occur.
- pH Balance: The acidic nature of chyme helps in activating enzymes in the small intestine, essential for digesting food efficiently.
Conclusion
In conclusion, the correct answer to the question regarding where chyme is formed is indeed the stomach. This organ's unique environment and mechanical action are vital for converting ingested food into chyme, facilitating its passage to the intestines for further digestion and nutrient absorption.

According to the attached passage, what event would need to occur to slow the signal to the respiratory centers?
Hypoxia is a term used to describe a set of symptoms, including fatigue, headaches, and confusion, that arise due to oxygen deprivation. When visiting the Rocky Mountains in the US, where the partial pressure of oxygen is approximately 15% lower than what one is accustomed to on the coast, these symptoms can be induced. The body has a limited tolerance for variations in environmental oxygen levels as it lacks a significant capacity to store oxygen, which is continuously consumed to maintain energy homeostasis.
In response to oxygen deprivation, the body increases the rate of breathing and the volume of each breath. This adjustment is part of a negative feedback loop that helps maintain homeostasis. The carotid body, located inside the carotid artery, serves as the sensor for detecting oxygen concentrations. The information gathered by the carotid body is then processed in the respiratory centers (RCs) of the brainstem's medulla. Ultimately, the output of this feedback loop is directed to the diaphragm, which plays a key role in respiration.
  • a)
    ATP production ceases in the cellular membranes.
  • b)
    Oxygen demand returns to normal.
  • c)
    Carbon dioxide levels increase.
  • d)
    Oxygen demand increases above 15%.
  • e)
    None of these
Correct answer is option 'C'. Can you explain this answer?

Orion Classes answered
The signal to the respiratory centers would slow as oxygen demands were met and the negative feedback loop acted to slow breathing and heart rate.
According to the provided passage, the event that would need to occur to slow the signal to the respiratory centers is when oxygen demand returns to normal. In the context of the passage, the body responds to oxygen deprivation by increasing the breathing rate and volume of each breath. This response is triggered by the detection of low oxygen concentrations by the carotid body sensor, which then sends a signal to the respiratory centers in the medulla. Once oxygen demand returns to normal and the body's oxygen needs are adequately met, the signal to the respiratory centers would slow down, leading to a decrease in the breathing rate and volume of each breath.

Q. What is the purpose of the folds called cristae in the mitochondrial membrane? (You may consult the attached passage.)
Mitochondria (singular = mitochondrion) are often called the “powerhouses” or “energy factories” of both plant and animal cells because they are responsible for making adenosine triphosphate (ATP), the cell’s main energy-carrying molecule. ATP represents the short-term stored energy of the cell. Cellular respiration is the process of making ATP using the chemical energy found in glucose and other nutrients. In mitochondria, this process uses oxygen and produces carbon dioxide as a waste product. In fact, the carbon dioxide that you exhale with every breath comes from the cellular reactions that produce carbon dioxide as a byproduct. Mitochondria are oval-shaped, double membrane organelles that have their own ribosomes and DNA. Each membrane is a phospholipid bilayer embedded with proteins. The inner layer has folds called cristae. The area surrounded by the folds is called the mitochondrial matrix. The cristae and the matrix have different roles in cellular respiration.
Dinitrophenol (DNP) was used in the manufacture of munitions in World War I. In the 1930s, it was used as a weight loss drug. Use in the U.S. cannot be regulated by the FDA because DNP is considered a dietary supplement. Attempts to ban the drug in the U.K. following the death of four users in 2015 failed in Parliament. DNP is a small molecule that is soluble in the mitochondrial inner membrane. The hydroxyl group reversibly dissociates a proton.
  • a)
    The folds increase the surface area of the inner membrane.
  • b)
    The folds provide structural stability to the mitochondria.
  • c)
    The folds transport water molecules and salt into the nucleus of the cell.
  • d)
    The folds store glucose and fructose reserves for photophosphorylation.
  • e)
    None of these
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
The folds that significantly increase the surface area within the mitochondria are known as cristae. These cristae play a crucial role in the production of energy in the form of ATP (adenosine triphosphate).
The mitochondria are often referred to as the powerhouse of the cell because they are responsible for cellular respiration, a process that generates ATP. The inner membrane of the mitochondria contains numerous cristae, which are inwardly folded structures. These folds increase the surface area available for crucial biochemical reactions involved in ATP synthesis.

Q. In prokaryotes, where is the DNA organized?
Prokaryotic DNA is arranged as a circular chromosome that is tightly coiled in the nucleoid region of the cell's cytoplasm. Genes involved in the same biochemical pathway or required for a specific function are grouped together in operons. An example of this is the lactose (or lac) operon, where all the genes needed for lactose metabolism are located in close proximity.
In prokaryotes, operon expression can be influenced by three types of regulatory molecules: repressors, activators, and inducers. Repressors are proteins that inhibit gene transcription in response to external stimuli, while activators are proteins that enhance gene transcription in response to external stimuli. Inducers, on the other hand, are small molecules that can either activate or inhibit gene transcription depending on the cell's needs and the availability of substrates.
In E. coli, the process of lactose digestion begins with the enzyme β-galactosidase breaking down lactose. The gene responsible for producing β-galactosidase, called lacZ, is part of an operon that is regulated in coordination with other genes involved in lactose utilization.
  • a)
    Nucleus
  • b)
    Nucleoid region
  • c)
    Mitochondria
  • d)
    Golgi apparatus
  • e)
    None of these
Correct answer is option 'B'. Can you explain this answer?

Elizabeth Lee answered



Prokaryotic DNA Organization
Prokaryotic DNA is organized as a circular chromosome that is tightly coiled in the nucleoid region of the cell's cytoplasm.

Operons
Genes involved in the same biochemical pathway or required for a specific function are grouped together in operons. An example of this is the lactose (or lac) operon, where all the genes needed for lactose metabolism are located in close proximity.

Regulatory Molecules
In prokaryotes, operon expression can be influenced by three types of regulatory molecules: repressors, activators, and inducers.
- Repressors: Proteins that inhibit gene transcription in response to external stimuli
- Activators: Proteins that enhance gene transcription in response to external stimuli
- Inducers: Small molecules that can either activate or inhibit gene transcription depending on the cell's needs and the availability of substrates.

Example: Lactose Digestion in E. coli
In E. coli, the process of lactose digestion begins with the enzyme β-galactosidase breaking down lactose. The gene responsible for producing β-galactosidase, called lacZ, is part of an operon that is regulated in coordination with other genes involved in lactose utilization.

A plant that lives in calcium- rich soil is called
  • a)
    Calcifuge
  • b)
    Calciplant
  • c)
    Limnophyte
  • d)
    Agarophyte
  • e)
    Calcicole
Correct answer is option 'E'. Can you explain this answer?

Ayesha Joshi answered
Calcicole plants are specialized plants that thrive in soils with high calcium content. They are adapted to tolerate or even benefit from the presence of calcium in the soil. These plants have specific physiological and biochemical adaptations that allow them to efficiently absorb and utilize calcium for their growth and development.

The substance that inactivates an enzyme by denaturing it is called
  • a)
    Feedback inhibitor
  • b)
    Competitive inhibitor
  • c)
    Allosteric inhibitor
  • d)
    Irreversible inhibitor
  • e)
    None of these
Correct answer is option 'D'. Can you explain this answer?

Understanding Enzyme Inactivation
Enzymes are biological catalysts that speed up chemical reactions in living organisms. However, certain substances can inactivate these enzymes, and it is crucial to understand how they work.
Types of Enzyme Inhibition
- Feedback Inhibitor: This type of inhibitor regulates metabolic pathways by binding to an enzyme involved in the pathway, usually at a site other than the active site. It does not necessarily denature the enzyme.
- Competitive Inhibitor: Competitive inhibitors bind to the active site of the enzyme, competing with the substrate. While they inhibit enzyme activity, they do not denature the enzyme.
- Allosteric Inhibitor: Allosteric inhibitors bind to a site other than the active site, causing a conformational change that decreases enzyme activity. They do not directly denature the enzyme.
Irreversible Inhibitor: The Correct Answer
- Definition: Irreversible inhibitors covalently bind to an enzyme, leading to permanent inactivation. This process often involves the denaturation of the enzyme, rendering it unable to perform its catalytic function.
- Mechanism: These inhibitors form strong covalent bonds with amino acid residues at or near the active site, causing structural changes that disrupt the enzyme’s function.
- Examples: Common irreversible inhibitors include certain drugs and toxins that permanently disable enzymes, affecting metabolic pathways.
Conclusion
In summary, the substance that inactivates an enzyme by denaturing it is indeed classified as an irreversible inhibitor. This is because it permanently alters the enzyme's structure, leading to a complete loss of activity, unlike other types of inhibitors that may be reversible or merely competitive. Understanding these distinctions is essential in biochemistry and pharmacology.

The lac operon in bacteria is an example of:
  • a)
    Positive gene regulation
  • b)
    Negative gene regulation
  • c)
    Post-translational regulation
  • d)
    Translational regulation
  • e)
    None of the above
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
The lac operon is negatively regulated by a repressor protein that binds to the operator region in the absence of lactose. This binding prevents RNA polymerase from transcribing the genes involved in lactose metabolism.

Which of the following is involved in post-transcriptional gene regulation?
  • a)
    Promoter
  • b)
    Spliceosome
  • c)
    Operator
  • d)
    Silencer
  • e)
    TATA box
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
The spliceosome is a complex of proteins and RNA molecules that removes introns from pre-mRNA during splicing, a process of post-transcriptional gene regulation. Alternative splicing can generate different mRNA isoforms with distinct functions.

Which of the following is NOT a method by which viruses can be transmitted?
  • a)
    Inhalation of respiratory droplets
  • b)
    Ingestion of contaminated food or water
  • c)
    Sexual contact
  • d)
    Hereditary transmission
  • e)
    None of these
Correct answer is option 'D'. Can you explain this answer?

Ayesha Joshi answered
Viruses are not transmitted through hereditary means (i.e., from parent to offspring). They can be transmitted through inhalation of respiratory droplets, ingestion of contaminated substances, and sexual contact.

Q. What did the researchers measure to compare the movement of oxygen molecules?
Cell membranes are composed of phospholipids and serve as the boundary for cells. Phospholipids consist of a pair of fatty acids, which can have carbon-carbon double bonds or not, connected to a three-carbon glycerol with a phosphate group. The structure of phospholipids forms a bilayer with hydrophilic phosphate ends facing the outer and inner surfaces of the membrane, while the hydrophobic fatty acid chains extend into the space between these surfaces. This selectively permeable membrane facilitates the exchange of substances between the cell's interior and its environment.
Due to the hydrophilic and hydrophobic nature of the plasma cell membrane, only certain molecules can passively diffuse between the cell's interior and the environment. The fluidity of the membrane affects passive transport, and the presence of other molecules, such as cholesterol, can significantly impact its fluidity. Temperature also influences membrane fluidity. Researchers conducted measurements to compare the speed of oxygen molecules (O2) moving through three types of membranes (lens lipid, POPC/CHOL, and POPC) with their movement through water. These measurements were conducted at different temperatures.
  • a)
    Movement through different types of cells
  • b)
    Movement through different types of membranes
  • c)
    Movement through water and air
  • d)
    Movement through different cellular compartments
  • e)
    None of these
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
The researchers compared the speed of oxygen molecules moving through different types of membranes, including lens lipid, POPC/CHOL, and POPC.

Q. What are inducers in prokaryotic gene regulation?
Prokaryotic DNA is arranged as a circular chromosome that is tightly coiled in the nucleoid region of the cell's cytoplasm. Genes involved in the same biochemical pathway or required for a specific function are grouped together in operons. An example of this is the lactose (or lac) operon, where all the genes needed for lactose metabolism are located in close proximity.
In prokaryotes, operon expression can be influenced by three types of regulatory molecules: repressors, activators, and inducers. Repressors are proteins that inhibit gene transcription in response to external stimuli, while activators are proteins that enhance gene transcription in response to external stimuli. Inducers, on the other hand, are small molecules that can either activate or inhibit gene transcription depending on the cell's needs and the availability of substrates.
In E. coli, the process of lactose digestion begins with the enzyme β-galactosidase breaking down lactose. The gene responsible for producing β-galactosidase, called lacZ, is part of an operon that is regulated in coordination with other genes involved in lactose utilization.
  • a)
    Proteins that inhibit transcription
  • b)
    Proteins that activate transcription
  • c)
    Small molecules that activate or repress transcription
  • d)
    Enzymes involved in lactose digestion
  • e)
    None of these
Correct answer is option 'C'. Can you explain this answer?

Ayesha Joshi answered
Inducers are small molecules that can either activate or repress gene transcription in prokaryotes, depending on the needs of the cell and the availability of substrates.

Casuarina flowers exhibit
  • a)
    Porogamy
  • b)
    Chalazogamy
  • c)
    Apogamy
  • d)
    Mesogamy
  • e)
    Acrogamy
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
Casuarina flowers exhibit chalazogamy, which is a type of fertilization that occurs when the pollen tube grows from the base of the ovule to reach the embryo sac. In chalazogamy, there is no direct connection between the pollen grains and the stigma. Instead, the pollen tube grows through the chalaza, which is the base of the ovule, and enters the embryo sac to fertilize the egg cell. This mechanism of fertilization is observed in some plants where the distance between the stigma and ovary is relatively large, and the pollen tube needs to navigate through the ovule to reach the female gametes.

During DNA replication, what would the complementary strand of DNA with the sequence ATGCCATGA look like?
  • a)
    UACGGUACU
  • b)
    GCUTTGCUG
  • c)
    TACGGTACT
  • d)
    GCATTGCAG
  • e)
    None of these
Correct answer is option 'C'. Can you explain this answer?

Ayesha Joshi answered
During DNA replication, the complementary strand of DNA is synthesized based on the pairing of nucleotides. In DNA, adenine (A) pairs with thymine (T), and cytosine (C) pairs with guanine (G).
The complementary strand of DNA with the sequence ATGCCATGA would be:
TACGGTACT
In the complementary strand, each nucleotide is paired with its complementary base. Adenine (A) is paired with thymine (T), thymine (T) is paired with adenine (A), cytosine (C) is paired with guanine (G), guanine (G) is paired with cytosine (C), and so on. Therefore, the complementary strand of DNA to ATGCCATGA is TACGGTACT.

The process by which RNA molecules are degraded and cleared from the cell is called:
  • a)
    RNA splicing
  • b)
    RNA capping
  • c)
    RNA editing
  • d)
    RNA interference
  • e)
    RNA decay
Correct answer is option 'E'. Can you explain this answer?

Ayesha Joshi answered
RNA decay refers to the process by which RNA molecules are degraded and cleared from the cell. It involves various mechanisms, including exonucleolytic degradation and endonucleolytic cleavage, leading to the removal of unwanted or damaged RNA molecules.

Which of the following is an example of a retrovirus?
  • a)
    Influenza virus
  • b)
    Measles virus
  • c)
    Human immunodeficiency virus (HIV)
  • d)
    Hepatitis C virus
  • e)
    Varicella-zoster virus
Correct answer is option 'C'. Can you explain this answer?

Ayesha Joshi answered
Retroviruses, such as HIV, are RNA viruses that use the enzyme reverse transcriptase to convert their RNA genome into DNA, which is then integrated into the host cell's genome. HIV is the causative agent of acquired immunodeficiency syndrome (AIDS).

Q. How are the hydrophilic phosphate ends of phospholipids oriented in the cell membrane?
Cell membranes are composed of phospholipids and serve as the boundary for cells. Phospholipids consist of a pair of fatty acids, which can have carbon-carbon double bonds or not, connected to a three-carbon glycerol with a phosphate group. The structure of phospholipids forms a bilayer with hydrophilic phosphate ends facing the outer and inner surfaces of the membrane, while the hydrophobic fatty acid chains extend into the space between these surfaces. This selectively permeable membrane facilitates the exchange of substances between the cell's interior and its environment.
Due to the hydrophilic and hydrophobic nature of the plasma cell membrane, only certain molecules can passively diffuse between the cell's interior and the environment. The fluidity of the membrane affects passive transport, and the presence of other molecules, such as cholesterol, can significantly impact its fluidity. Temperature also influences membrane fluidity. Researchers conducted measurements to compare the speed of oxygen molecules (O2) moving through three types of membranes (lens lipid, POPC/CHOL, and POPC) with their movement through water. These measurements were conducted at different temperatures.
  • a)
    Facing each other within the bilayer
  • b)
    Facing the external environment
  • c)
    Facing the cell's interior
  • d)
    Randomly distributed throughout the membrane
  • e)
    None of these
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
The hydrophilic phosphate ends of phospholipids face the outer and inner surfaces of the cell membrane.

Which of the following develops from ectoderm?
  • a)
    Liver
  • b)
    Pancreas
  • c)
    Kidney
  • d)
    Stomach
  • e)
    Brain
Correct answer is option 'E'. Can you explain this answer?

Ayesha Joshi answered
The ectoderm is one of the three primary germ layers formed during early embryonic development. It gives rise to various structures and tissues in the body. One of the major structures that develop from the ectoderm is the brain, which is a crucial part of the central nervous system.
The brain is a complex organ responsible for controlling various bodily functions, processing sensory information, and coordinating motor activities. During embryonic development, the neural tube, which is derived from the ectoderm, undergoes extensive differentiation and specialization to form the brain and spinal cord.
The other options listed (liver, pancreas, kidney, and stomach) are derived from different germ layers. The liver and pancreas develop from the endoderm, which forms the lining of the digestive tract. The kidney arises from the intermediate mesoderm, and the stomach develops from both the endoderm and mesoderm.
Therefore, among the options provided, only the brain develops from the ectoderm.

Q. What events occur in the anaphase stage of mitosis? (You may consult the attached passage and graphic.)
The Cell Cycle:
The cell cycle is a carefully regulated sequence of events that involves cell growth and division, resulting in the production of two daughter cells. Cells progress through distinct stages of growth, DNA replication, and division to generate two identical cells. The cell cycle consists of two main phases: interphase and the mitotic phase. Interphase involves cell growth and DNA replication, while the mitotic phase encompasses the separation of replicated DNA and cytoplasmic contents, leading to cell division.
In a research study focusing on cell division, scientists cultivate human cells undergoing synchronous division using thymidine. This causes the cells to pause at the G1G1 boundary. Subsequently, the cells are transferred to a thymidine-free medium, which releases the block and allows the cells to resume dividing. Four different samples (A-D) are taken at various time points after thymidine removal to measure the DNA content of the cells. The results for these samples are presented in the graph.
Li-Fraumeni Syndrome:
Li-Fraumeni syndrome (LFS1) is a rare inherited condition associated with an increased susceptibility to cancer. This syndrome is linked to mutations in the tumor suppressor gene that encodes the transcription factor p53, which plays a crucial role at the G1 checkpoint of the cell cycle. When damaged DNA is detected, p53 halts the progression of the cell cycle. As p53 levels rise, it triggers the production of p21, a protein that enforces the cell cycle arrest. Another form of Li-Fraumeni syndrome, known as LFS2, is believed to be caused by a mutation in the CHK2 gene, which also functions as a tumor suppressor. CHK2 regulates the activity of p53 in the cell cycle
  • a)
    Chromosomes line up at the metaphase plate and the mitotic spindle is developed.
  • b)
    Chromosomes become visible as they condense and the nucleolus breaks down.
  • c)
    Sister chromatids bind together and move toward opposite poles.
  • d)
    Sister chromatids begin to split and form a membrane around themselves.
  • e)
    None of these
Correct answer is option 'C'. Can you explain this answer?

Ayesha Joshi answered
Anaphase is the fourth stage in the cycle where sister chromatids bind together and move toward opposite poles to eventually become two individual cells.

Which of these is not a female sex hormone?
  • a)
    gastrin
  • b)
    estrogen
  • c)
    follicle stimulating hormone
  • d)
    progesterone
  • e)
    Both (a) and (c)
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
Gastrin is not a female sex hormone. It is a hormone that plays a role in the digestive system by stimulating the production of gastric acid in the stomach. Estrogen, follicle stimulating hormone (FSH), and progesterone are all female sex hormones. Estrogen is responsible for the development and maintenance of female reproductive structures and secondary sexual characteristics. FSH plays a crucial role in the menstrual cycle and the development of ovarian follicles. Progesterone is involved in the preparation of the uterus for pregnancy and the maintenance of pregnancy.

Q. People with Li-Fraumeni syndrome (LFS1) would likely experience what type of medical challenges? (You may consult the attached passage and graphic.)
The Cell Cycle:
The cell cycle is a carefully regulated sequence of events that involves cell growth and division, resulting in the production of two daughter cells. Cells progress through distinct stages of growth, DNA replication, and division to generate two identical cells. The cell cycle consists of two main phases: interphase and the mitotic phase. Interphase involves cell growth and DNA replication, while the mitotic phase encompasses the separation of replicated DNA and cytoplasmic contents, leading to cell division.
In a research study focusing on cell division, scientists cultivate human cells undergoing synchronous division using thymidine. This causes the cells to pause at the G1G1 boundary. Subsequently, the cells are transferred to a thymidine-free medium, which releases the block and allows the cells to resume dividing. Four different samples (A-D) are taken at various time points after thymidine removal to measure the DNA content of the cells. The results for these samples are presented in the graph.
Li-Fraumeni Syndrome:
Li-Fraumeni syndrome (LFS1) is a rare inherited condition associated with an increased susceptibility to cancer. This syndrome is linked to mutations in the tumor suppressor gene that encodes the transcription factor p53, which plays a crucial role at the G1 checkpoint of the cell cycle. When damaged DNA is detected, p53 halts the progression of the cell cycle. As p53 levels rise, it triggers the production of p21, a protein that enforces the cell cycle arrest. Another form of Li-Fraumeni syndrome, known as LFS2, is believed to be caused by a mutation in the CHK2 gene, which also functions as a tumor suppressor. CHK2 regulates the activity of p53 in the cell cycle
  • a)
    high blood pressure and blood cholesterol
  • b)
    increased risk of tumor development
  • c)
    immune system impairment
  • d)
    development of aneurysms in the lungs
  • e)
    None of these
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
People that are diagnosed with Li-Fraumeni syndrome (LFS1) have a defect in their tumor-suppression mechanisms and would therefore be prone to the development of tumors.

Q. What occurs during the lytic cycle of a virus? (You may consult the attached reference.)
A simple calculation of the rate of spread of a pox virus (virion) led researchers at Imperial College London to a new insight. Virions communicate with other virions. The researchers observed that the radius of an approximately circular plaque of infected cells grew to 1.45 mm in just 3 days. They measured the distance between adjacent cells to be 0.037 mm to obtain the apparent time for the lytic cycle (from infection to lysis). They compared this time to the actual rate at which new virions are formed: 5 to 6 hours.
To account for this discrepancy between observed and predicted growth rates, the researchers examined the viral entry process and discovered that the actin protein on the host cell’s surface that provided the viral receptor was modified by attachment. They then found a mutant virus that did not modify the cell surface protein. The dependence of the growth of plaque radius on time for the wild type and mutant are shown in the graph.
  • a)
    The virus infects the host cell and causes immediate host cell death.
  • b)
    The virus transforms into a mutated host cell.
  • c)
    The virus is unable to infect a cell until it acquires a mutation.
  • d)
    The virus infects the cell and hides out in the cellular DNA for an extended period of time.
  • e)
    None of the above
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
During the lytic cycle in viral infections, the virus infects the host cell and uses the cellular machinery to create more virus particles.

What is the function of the gall bladder?
  • a)
    to produce bile
  • b)
    To store bile
  • c)
    to produce insulin
  • d)
    to store insulin
  • e)
    none of these
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
The function of the gallbladder is to store bile. Bile is a digestive fluid produced by the liver that helps in the breakdown and absorption of fats. The liver continuously produces bile, and the gallbladder acts as a storage reservoir for bile. When we consume a fatty meal, the gallbladder contracts and releases bile into the small intestine to aid in the digestion and absorption of fats. 

Which of the following blood components carries dissolved nutrients?
  • a)
    Red blood cells
  • b)
    White blood cells
  • c)
    Platelets
  • d)
    Plasma
  • e)
    None of the above
Correct answer is option 'D'. Can you explain this answer?

Ayesha Joshi answered
Plasma is the liquid portion of blood and makes up the largest portion of blood volume. It is responsible for transporting various substances, including dissolved nutrients, hormones, gases, and waste products throughout the body. While red blood cells, white blood cells, and platelets have important roles in blood function, it is the plasma that carries dissolved nutrients.

Respiratory patients are sometimes placed in the ____ position to help with breathing, which means the patient would be placed lying face down on the bed.
  • a)
    lateral
  • b)
    terminal
  • c)
    supine
  • d)
    prone
  • e)
    none of these
Correct answer is option 'D'. Can you explain this answer?

Ayesha Joshi answered
The prone position refers to the position where a person lies face down, with their chest and abdomen resting on the surface. This position is sometimes used for respiratory patients because it can help improve lung function and oxygenation. By lying prone, the weight of the abdominal organs and the diaphragm is shifted, allowing for better expansion of the lungs and improved ventilation. It can be particularly beneficial for patients with acute respiratory distress syndrome (ARDS) or other conditions that cause difficulty in breathing. However, it is important to note that the use of the prone position should be determined by a healthcare professional based on the individual patient's condition and needs.

Q. How would hydrogen cyanide affect the pH of the intermembrane space? (You may consult the attached passage.)
Mitochondria (singular = mitochondrion) are often called the “powerhouses” or “energy factories” of both plant and animal cells because they are responsible for making adenosine triphosphate (ATP), the cell’s main energy-carrying molecule. ATP represents the short-term stored energy of the cell. Cellular respiration is the process of making ATP using the chemical energy found in glucose and other nutrients. In mitochondria, this process uses oxygen and produces carbon dioxide as a waste product. In fact, the carbon dioxide that you exhale with every breath comes from the cellular reactions that produce carbon dioxide as a byproduct. Mitochondria are oval-shaped, double membrane organelles that have their own ribosomes and DNA. Each membrane is a phospholipid bilayer embedded with proteins. The inner layer has folds called cristae. The area surrounded by the folds is called the mitochondrial matrix. The cristae and the matrix have different roles in cellular respiration.
Dinitrophenol (DNP) was used in the manufacture of munitions in World War I. In the 1930s, it was used as a weight loss drug. Use in the U.S. cannot be regulated by the FDA because DNP is considered a dietary supplement. Attempts to ban the drug in the U.K. following the death of four users in 2015 failed in Parliament. DNP is a small molecule that is soluble in the mitochondrial inner membrane. The hydroxyl group reversibly dissociates a proton.
  • a)
    Cyanide neutralizes the pH of the intermembrane space.
  • b)
    Cyanide lowers the pH of the intermembrane space.
  • c)
    Cyanide does not impact the pH of the intermembrane space.
  • d)
    Cyanide raises the pH of the intermembrane space.
  • e)
    None of these
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
Hydrogen Cyanide (HCN) releases protons (H+ ions) into the solution following the equilibrium HCN + H2O ⇌ H+ + CN-. The pH would be lower due to an increase in H+, which makes the solution more acidic.

Q. Tracie is a 29-year-old female with Rett syndrome, a rare X-linked dominant neurological disorder. Tracie is heterozygous for the trait. She marries Jax and they have one daughter. If Jax does not carry any copies of the Rett syndrome gene, what are the chances that their daughter will inherit the gene for Rett syndrome? (You may consult the attached passage.)
Adrenoleukodystrophy (ALD) is a genetic disorder in which lipids with very high molecular weights are not metabolized and accumulate within cells. Accumulation of these fats in the brain damages the myelin that surrounds nerves. This progressive disease has two causes: an autosomal recessive allele, which causes neonatal ALD, and a mutation in the ABCD1 gene located on the X chromosome. A controversial treatment is the use of Lorenzo’s oil, which is expensive; despite this treatment, neurological degradation persists in many patients. Gene therapy as a potential treatment is currently in trials but is also very costly. An infant patient exhibits symptoms of neonatal ALD, which are difficult to distinguish from the X-linked form of the disease. The infant’s physician consults electronic health records to construct a pedigree showing family members who also presented symptoms similar to ALD. The pedigree is shown in this diagram. The infant patient is circled. Symbols are filled when symptoms are present.
  • a)
    75%
  • b)
    50%
  • c)
    0%
  • d)
    100%
  • e)
    5%
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
Females get one X chromosome from their mother and one X chromosome from their father. If the mother is heterozygous for Rett syndrome, she has one copy of the gene. The daughter has a 50% chance of inheriting the gene, though her likelihood of developing the syndrome are minimal.

A region with high level of endemic species that is under threat from humans is called
  • a)
    Botanical garden
  • b)
    Wild life Sanctuaries
  • c)
    Zoos
  • d)
    Biodiversity hotspot
  • e)
    None of these
Correct answer is option 'D'. Can you explain this answer?

Ayesha Joshi answered
Hotspots are indeed regions characterized by a significant reservoir of biodiversity, often hosting a high number of endemic species. These areas are particularly vulnerable to threats posed by human activities, including habitat destruction, pollution, and climate change.
A botanical garden is a place specifically designed for the cultivation and display of plants. It serves educational, scientific, and ornamental purposes, providing a controlled environment for the study, conservation, and enjoyment of various plant species.
Wildlife sanctuaries, on the other hand, are areas set aside to conserve and protect the natural habitat and wildlife within them. These areas are usually designated with the goal of minimizing human intervention, allowing animal populations to thrive undisturbed. Human activities such as hunting or extraction of resources are generally restricted or prohibited within wildlife sanctuaries.
A zoo is an institution where living animals are kept and often exhibited to the public. Zoos aim to educate the public about different animal species, contribute to conservation efforts, and provide opportunities for research and breeding programs. While zoos can play a role in conservation and education, their ethical practices and treatment of animals have been subject to ongoing discussions and debates.
Overall, these terms describe different aspects of biodiversity conservation, plant cultivation, and the exhibition of animals, each serving unique purposes and facing specific challenges in our interaction with the natural world.

Which of the following metals is responsible for Itai-itai disease?
  • a)
    Arsenic
  • b)
    Cadmium
  • c)
    Lead
  • d)
    Mercury
  • e)
    Uranium
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
Itai-itai disease is a condition caused by chronic cadmium poisoning. It was first identified in Japan and primarily affected individuals residing near mining areas contaminated with cadmium. The main symptom of the disease is weak and brittle bones, leading to severe pain and fractures. Itai-itai disease is particularly characterized by spinal and leg bone pain in the initial stages. Prolonged exposure to cadmium can also lead to kidney damage and eventually kidney failure, which is a serious complication associated with the disease.

An animal with two successive sets of teeth is called
  • a)
    Diphyodont
  • b)
    Monophyodont
  • c)
    Heterodont
  • d)
    Polyphodont
  • e)
    None of the above
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
Diphyodonts are organisms that have two sets of teeth, known as deciduous teeth (also called baby teeth or milk teeth) and permanent teeth. The deciduous teeth are gradually replaced by the permanent teeth as the organism grows and develops.
On the other hand, monophyodonts are organisms that have only one set of teeth, which are not replaced at later stages of life. They do not undergo a process of tooth replacement or continuous growth.
Heterodonts are organisms that possess different types of teeth specialized for various functions. They have distinct tooth types such as incisors, canines, premolars, and molars, each serving a specific purpose in the oral cavity.
Polyphodonts are organisms whose teeth are continuously replaced throughout their lives. As their teeth wear out or become damaged, new teeth continuously grow and replace the old ones, ensuring a functional dentition is maintained. This process of tooth replacement is observed in certain species such as sharks and reptiles.

Which pigment absorbs the red and far-red light?
  • a)
    Chlorophyll A
  • b)
    Chlorophyll B
  • c)
    Carotenoid
  • d)
    Xanthophylls
  • e)
    Phytochrome
Correct answer is option 'E'. Can you explain this answer?

Ayesha Joshi answered
Carotenoids are pigments found in plants that play a vital role in photosynthesis. These pigments are responsible for reflecting yellow and red light, contributing to the overall coloration of plants. Carotenoids work in conjunction with chlorophyll, the primary pigment involved in photosynthesis. While chlorophyll primarily absorbs light energy, carotenoids absorb light at different wavelengths and transfer this energy to chlorophyll, enhancing the efficiency of photosynthesis. Due to their characteristic orange color, carotenoids are often referred to as orange photosynthetic pigments.

Q. What are cell membranes primarily composed of?
Cell membranes are composed of phospholipids and serve as the boundary for cells. Phospholipids consist of a pair of fatty acids, which can have carbon-carbon double bonds or not, connected to a three-carbon glycerol with a phosphate group. The structure of phospholipids forms a bilayer with hydrophilic phosphate ends facing the outer and inner surfaces of the membrane, while the hydrophobic fatty acid chains extend into the space between these surfaces. This selectively permeable membrane facilitates the exchange of substances between the cell's interior and its environment.
Due to the hydrophilic and hydrophobic nature of the plasma cell membrane, only certain molecules can passively diffuse between the cell's interior and the environment. The fluidity of the membrane affects passive transport, and the presence of other molecules, such as cholesterol, can significantly impact its fluidity. Temperature also influences membrane fluidity. Researchers conducted measurements to compare the speed of oxygen molecules (O2) moving through three types of membranes (lens lipid, POPC/CHOL, and POPC) with their movement through water. These measurements were conducted at different temperatures.
  • a)
    Proteins
  • b)
    Carbohydrates
  • c)
    Phospholipids
  • d)
    Cholesterols
  • e)
    None of these
Correct answer is option 'C'. Can you explain this answer?

Ayesha Joshi answered
Cell membranes are primarily composed of phospholipids, which form a bilayer structure.

Q. Based on the attached passage and graphic, which of the following cycles is Sample A currently in, based on the relative DNA content of the sample?
The Cell Cycle:
The cell cycle is a carefully regulated sequence of events that involves cell growth and division, resulting in the production of two daughter cells. Cells progress through distinct stages of growth, DNA replication, and division to generate two identical cells. The cell cycle consists of two main phases: interphase and the mitotic phase. Interphase involves cell growth and DNA replication, while the mitotic phase encompasses the separation of replicated DNA and cytoplasmic contents, leading to cell division.
In a research study focusing on cell division, scientists cultivate human cells undergoing synchronous division using thymidine. This causes the cells to pause at the G1G1 boundary. Subsequently, the cells are transferred to a thymidine-free medium, which releases the block and allows the cells to resume dividing. Four different samples (A-D) are taken at various time points after thymidine removal to measure the DNA content of the cells. The results for these samples are presented in the graph.
Li-Fraumeni Syndrome:
Li-Fraumeni syndrome (LFS1) is a rare inherited condition associated with an increased susceptibility to cancer. This syndrome is linked to mutations in the tumor suppressor gene that encodes the transcription factor p53, which plays a crucial role at the G1 checkpoint of the cell cycle. When damaged DNA is detected, p53 halts the progression of the cell cycle. As p53 levels rise, it triggers the production of p21, a protein that enforces the cell cycle arrest. Another form of Li-Fraumeni syndrome, known as LFS2, is believed to be caused by a mutation in the CHK2 gene, which also functions as a tumor suppressor. CHK2 regulates the activity of p53 in the cell cycle
  • a)
    G1
  • b)
    G2
  • c)
    mitosis
  • d)
    cytokinesis
  • e)
    Both (a) and  (b)
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
The observed sample has not yet undergone a doubling of its relative DNA content, indicating that it is currently in the G1 phase of the cell cycle.

The process by which the information in mRNA is used to synthesize a protein is called:
  • a)
    Translation
  • b)
    Transcription
  • c)
    Replication
  • d)
    Reverse transcription
  • e)
    Transduction
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
Translation is the process in which the information in mRNA is used by ribosomes to synthesize proteins. It involves the decoding of the mRNA sequence into a specific sequence of amino acids.

Glucocorticoid is produced by
  • a)
    Adrenal medulla
  • b)
    Adrenal cortex
  • c)
    Pancreas
  • d)
    Pineal gland
  • e)
    Pituitary gland
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
Glucocorticoids are synthesized and secreted by the adrenal cortex, a part of the adrenal glands. They belong to a class of steroid hormones and exert their effects by binding to specific receptors called glucocorticoid receptors. Glucocorticoids have various physiological functions, including the regulation of carbohydrate metabolism. One of their prominent actions is the stimulation of gluconeogenesis, a process that leads to the production of glucose from non-carbohydrate sources such as amino acids and fatty acids. This results in an increase in blood glucose levels, which is important for providing energy to the body during times of stress or fasting.

The structure of a protein with linear sequence of amino acids is called
  • a)
    Primary structure
  • b)
    Secondary structure
  • c)
    Tertiary structure
  • d)
    Quaternary structure
  • e)
    None of the above
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
The primary structure of a protein refers to the linear sequence of amino acids that make up the protein chain. It is the most basic level of protein structure and is determined by the specific arrangement of amino acids in the polypeptide chain. The sequence of amino acids is encoded by the genetic information in DNA.
Secondary structure (B) refers to the local folding patterns that result from hydrogen bonding between nearby amino acids. Examples of secondary structures include alpha helices and beta sheets.
Tertiary structure (C) is the three-dimensional folding of the entire protein molecule, including interactions between amino acid side chains. It determines the overall shape and functional properties of the protein.
Quaternary structure (D) is the arrangement of multiple protein subunits in a multisubunit complex. It describes the interactions between different protein chains or subunits.
Therefore, the structure of a protein with a linear sequence of amino acids is referred to as the primary structure (A).

Chains of sarcomeres in muscles are organized into
  • a)
    Sarcolemma
  • b)
    Sarcoplasm
  • c)
    Myoblasts
  • d)
    Myofibrils
  • e)
    Fascia
Correct answer is option 'D'. Can you explain this answer?

Ayesha Joshi answered
Muscles are composed of specialized contractile units called sarcomeres. Sarcomeres are the functional units of muscle fibers and are responsible for muscle contraction. They are made up of chains of protein filaments, including actin and myosin, which slide past each other to generate muscle contraction.
The chains of sarcomeres are organized within muscle fibers into long cylindrical structures called myofibrils. Myofibrils are thread-like structures that extend the entire length of a muscle fiber and are responsible for the striated appearance of skeletal and cardiac muscles. They are composed of repeating units of sarcomeres, which are aligned end to end.
The sarcolemma is the plasma membrane of a muscle cell, also known as a muscle fiber. It surrounds and encloses the sarcoplasm, which is the cytoplasm of the muscle cell. However, sarcolemma is not involved in the organization of sarcomeres within the muscle.
Sarcoplasm is the cytoplasm of muscle cells and contains various cellular components including myofibrils. While myofibrils are located within the sarcoplasm, they specifically refer to the chains of sarcomeres organized in a sequential manner.
Myoblasts are the embryonic cells that fuse together during development to form mature muscle fibers. They are involved in the initial formation of muscle tissue but do not directly organize the chains of sarcomeres.
Fascia is a connective tissue that surrounds and separates muscles and other organs. It provides support and structure but is not directly involved in the organization of sarcomeres.
Therefore, the correct answer is D. Myofibrils, as they are the structures that organize the chains of sarcomeres within muscle fibers.

Lowest area of water body is called
  • a)
    Littoral zone
  • b)
    Aphotic zone
  • c)
    Photic zone
  • d)
    Benthic zone
  • e)
    None of the above
Correct answer is option 'D'. Can you explain this answer?

Ayesha Joshi answered
Lowest area of water body such as ocean or lake is called as benthic zone. Organisms living in this zone are called as Benthos. Littoral zone is the region of lake, sea or ocean. Aphotic zone is the zone of water body which lacks sunlight. Photic zone is the upper part of water body to which enough sunlight penetrates and permits photosynthesis.

Which of the following glands secrete the FSH hormone?
  • a)
    Islets of Langerhans
  • b)
    Anterior pituitary gland
  • c)
    Posterior pituitary gland
  • d)
    Parathyroid gland
  • e)
    Testis
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
Follicle stimulating hormone (FSH) is secreted by the anterior pituitary gland. In males, FSH plays a crucial role in stimulating spermatogenesis, the production of sperm cells. In females, FSH stimulates the growth and development of ovarian follicles, which contain the eggs. Besides FSH, the anterior pituitary gland also secretes several other hormones including luteinising hormone, prolactin, thyroid stimulating hormone, adrenocorticotrophic hormone, and growth hormone.

The adipose tissue plays role in
  • a)
    Pigment storage
  • b)
    Fat storage
  • c)
    Stretching
  • d)
    Binding organs
  • e)
    None of the above
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
Adipose tissue, also known as body fat or fatty tissue, is a specialized type of connective tissue primarily responsible for storing and releasing energy in the form of fat. It consists of adipocytes, which are specialized cells that contain large lipid droplets.
The main role of adipose tissue is to store excess energy in the form of triglycerides, which are composed of fatty acids and glycerol. When the body needs energy, adipose tissue releases stored fat by breaking down triglycerides into fatty acids and glycerol through a process called lipolysis. These fatty acids are then released into the bloodstream and used as a source of energy by various tissues and organs in the body.
Adipose tissue also serves other functions in the body, including insulation and protection. It helps to insulate the body by providing a layer of fat that acts as a thermal barrier, helping to regulate body temperature. Additionally, adipose tissue cushions and protects organs by providing a layer of padding around them, helping to absorb shock and minimize physical damage.

Implantation is the process where
  • a)
    The blastocyst becomes embedded in the endometrium.
  • b)
    The sperm nuclei fuse with the egg nuclei
  • c)
    Loss of the lining of endometrium takes place
  • d)
    The gastrula becomes embedded in the endometrium
  • e)
    None of the above
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
Implantation is a critical step in the process of human reproduction. It occurs after fertilization, when the developing embryo, in the form of a blastocyst, attaches itself to the lining of the uterus, known as the endometrium.
After fertilization, the zygote undergoes multiple cell divisions and forms a hollow ball of cells called a blastocyst. The blastocyst then travels through the fallopian tube and reaches the uterus. During implantation, the blastocyst attaches itself to the thickened and enriched endometrial lining of the uterus.
Implantation involves several complex processes. The blastocyst first makes contact with the endometrium and then burrows into it, eventually becoming embedded in the endometrial tissue. This establishes a connection between the developing embryo and the maternal blood supply, which is crucial for the exchange of nutrients, oxygen, and waste products.
Implantation typically occurs around 6 to 7 days after fertilization, and it marks the beginning of pregnancy. Following successful implantation, the endometrium undergoes further changes to support the growth and development of the embryo, leading to the formation of the placenta.
The other options listed are not accurate descriptions of implantation. B. The fusion of sperm nuclei with egg nuclei is known as fertilization, which occurs prior to implantation. C. Loss of the lining of the endometrium is associated with menstruation, not implantation. D. The gastrula stage refers to a later developmental stage, after implantation has already taken place.
Therefore, the correct answer is A. The blastocyst becomes embedded in the endometrium. Implantation is the crucial process in which the developing embryo attaches itself to the uterine lining to establish pregnancy.

Which among the following processes results in dark coloured amorphous substance during decomposition in soil?
  • a)
    Mineralization
  • b)
    Fragmentation
  • c)
    Leaching
  • d)
    Humification
  • e)
    None of the above
Correct answer is option 'D'. Can you explain this answer?

Ayesha Joshi answered
The decomposition process in soil encompasses two main processes: humification and mineralization. Humification involves the accumulation of a dark-colored, amorphous substance known as humus. Humus serves as a nutrient reservoir, resisting microbial breakdown and thereby resulting in slow decomposition. Over time, humus can undergo further degradation by microorganisms, leading to mineralization. Mineralization refers to the conversion of organic matter into inorganic forms, releasing nutrients that become available for uptake by plants and other organisms.

Q. According to the information in the attached chart, which of the adipocytokines showed an increase when compared to the control group after four weeks of treatment with B12?
Water and the energy-yielding nutrients are also referred to as macronutrients because the body needs them in large amounts. In contrast, micronutrients are vitamins and minerals. These elements and compounds participate in many essential chemical reactions and processes, such as nerve impulses, and some, such as calcium, also contribute to the body’s structure. Your body can store some of the micronutrients in its tissues, and draw on those reserves if you fail to consume them in your diet for a few days or weeks. Some other micronutrients, such as vitamin C and most of the B vitamins, are water-soluble and cannot be stored, so you need to consume them every day or two.
Vitamin B12  is a co-enzyme involved in a wide variety of cellular processes. Synthesis of vitamin B12 occurs only in bacteria; in animals, these bacteria populate anaerobic environments in the gut. Consequently, vegan diets in developing nations and diets common to developing nations provide no source of B12 . Researchers (Ghosh et al. http://dx.doi.org/10.3389/fnut.2016.00001) found that rats whose diets contained limited (L) and no (N) B12 displayed symptoms that were not observed in the control group (C) whose diet included B12  and was otherwise identical. Chemical analysis of adipocytokines in the plasma after feeding periods of 4 and 12 weeks are shown in the following table. Over the 12 weeks of feeding, the weights of all three groups were equivalent, while the percent of body fat increased relative to the control for the rats fed a diet of limited and no B12: 40% (N) and 20% (L), respectively.
  • a)
    leptin only
  • b)
    adipose and monocytes
  • c)
    leptin, MCP-1, and IL-6
  • d)
    MCP-1 and adipose
  • e)
    None of these
Correct answer is option 'C'. Can you explain this answer?

Ayesha Joshi answered
Leptin, MCP-1, and IL-6 all showed an increase after four weeks of treatment when compared to the control.

Which of the following kinds of signalling occurs when the cells communicate with each other through direct contact?
  • a)
    Endocrine signalling
  • b)
    Paracrine signalling
  • c)
    Juxtacrine signalling
  • d)
    Intracrine signalling
  • e)
    None of the above
Correct answer is option 'C'. Can you explain this answer?

Ayesha Joshi answered
Juxtacrine signaling is a form of cell signaling in which cells directly interact with each other through physical contact. In this type of signaling, molecules present on the surface of one cell bind to receptors on the surface of an adjacent cell, transmitting signals and triggering specific cellular responses.
Endocrine signaling (option A) involves the release of signaling molecules (hormones) into the bloodstream, which then travel to target cells or tissues located at a distance from the signaling cell.
Paracrine signaling (option B) occurs when signaling molecules are released by a cell and act on nearby cells in the immediate vicinity of the signaling cell.
Intracrine signaling (option D) involves the production of signaling molecules that act within the same cell, without being released into the extracellular space.
Therefore, the correct answer is C. Juxtacrine signaling, which describes the direct contact and interaction between cells for communication.

Nematocyst is a characteristic feature of
  • a)
    Echinoderms
  • b)
    Arthropods
  • c)
    Molluscs
  • d)
    Cnidarians
  • e)
    Porifera
Correct answer is option 'D'. Can you explain this answer?

Ayesha Joshi answered
Nematocysts are a characteristic feature of cnidarians. Cnidarians are a group of animals that includes jellyfish, corals, sea anemones, and hydras. Nematocysts are specialized stinging cells found in cnidarians. They are used for prey capture, defense, and movement. Nematocysts contain a coiled thread-like structure called a cnidocyst, which is expelled when triggered by touch or chemical stimuli. The cnidocyst delivers a toxin or venom to immobilize or kill prey, deter predators, or for self-defense. Nematocysts are unique to cnidarians and play a crucial role in their survival and interaction with the environment.

Q. Tammy is a 37-year-old female affected with hemophilia A, an X-linked recessive disorder that affects blood clotting. Tammy marries Jason and they have one son. If Jason does not carry any copies of the hemophilia A gene, what are the chances that their son will have hemophilia A? (You may consult the attached passage.)
Adrenoleukodystrophy (ALD) is a genetic disorder in which lipids with very high molecular weights are not metabolized and accumulate within cells. Accumulation of these fats in the brain damages the myelin that surrounds nerves. This progressive disease has two causes: an autosomal recessive allele, which causes neonatal ALD, and a mutation in the ABCD1 gene located on the X chromosome. A controversial treatment is the use of Lorenzo’s oil, which is expensive; despite this treatment, neurological degradation persists in many patients. Gene therapy as a potential treatment is currently in trials but is also very costly. An infant patient exhibits symptoms of neonatal ALD, which are difficult to distinguish from the X-linked form of the disease. The infant’s physician consults electronic health records to construct a pedigree showing family members who also presented symptoms similar to ALD. The pedigree is shown in this diagram. The infant patient is circled. Symbols are filled when symptoms are present.
  • a)
    100%
  • b)
    75%
  • c)
    50%
  • d)
    0%
  • e)
    10%
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
Males get one X chromosome from their mother and one Y chromosome from their father. If the mother has hemophilia A, she has two copies of the gene because the disease is recessive. The son will inherit a copy of the gene and, because he will only have one X chromosome, he will have the disease.

Q. p53 acts at the G1 checkpoint. If genetic mutations are found, p53 will not allow the cell to proceed to the next step of the cell cycle, which would be ____. (You may consult the attached passage and graphic.)
The Cell Cycle:
The cell cycle is a carefully regulated sequence of events that involves cell growth and division, resulting in the production of two daughter cells. Cells progress through distinct stages of growth, DNA replication, and division to generate two identical cells. The cell cycle consists of two main phases: interphase and the mitotic phase. Interphase involves cell growth and DNA replication, while the mitotic phase encompasses the separation of replicated DNA and cytoplasmic contents, leading to cell division.
In a research study focusing on cell division, scientists cultivate human cells undergoing synchronous division using thymidine. This causes the cells to pause at the G1G1 boundary. Subsequently, the cells are transferred to a thymidine-free medium, which releases the block and allows the cells to resume dividing. Four different samples (A-D) are taken at various time points after thymidine removal to measure the DNA content of the cells. The results for these samples are presented in the graph.
Li-Fraumeni Syndrome:
Li-Fraumeni syndrome (LFS1) is a rare inherited condition associated with an increased susceptibility to cancer. This syndrome is linked to mutations in the tumor suppressor gene that encodes the transcription factor p53, which plays a crucial role at the G1 checkpoint of the cell cycle. When damaged DNA is detected, p53 halts the progression of the cell cycle. As p53 levels rise, it triggers the production of p21, a protein that enforces the cell cycle arrest. Another form of Li-Fraumeni syndrome, known as LFS2, is believed to be caused by a mutation in the CHK2 gene, which also functions as a tumor suppressor. CHK2 regulates the activity of p53 in the cell cycle
  • a)
    G0
  • b)
    G2
  • c)
    cytokinesis
  • d)
    S phase
  • e)
    All of above
Correct answer is option 'C'. Can you explain this answer?

Ayesha Joshi answered
The cell cycle consists of several distinct phases, which include G1 (Gap 1), followed by S (Synthesis), and then G2 (Gap 2). After the completion of G2, cytokinesis takes place, leading to the division of the cell.

Q. Which of the following represents the correct sequence of phases in mitosis? (You may consult the attached passage and graphic.)
The Cell Cycle:
The cell cycle is a carefully regulated sequence of events that involves cell growth and division, resulting in the production of two daughter cells. Cells progress through distinct stages of growth, DNA replication, and division to generate two identical cells. The cell cycle consists of two main phases: interphase and the mitotic phase. Interphase involves cell growth and DNA replication, while the mitotic phase encompasses the separation of replicated DNA and cytoplasmic contents, leading to cell division.
In a research study focusing on cell division, scientists cultivate human cells undergoing synchronous division using thymidine. This causes the cells to pause at the G1G1 boundary. Subsequently, the cells are transferred to a thymidine-free medium, which releases the block and allows the cells to resume dividing. Four different samples (A-D) are taken at various time points after thymidine removal to measure the DNA content of the cells. The results for these samples are presented in the graph.
Li-Fraumeni Syndrome:
Li-Fraumeni syndrome (LFS1) is a rare inherited condition associated with an increased susceptibility to cancer. This syndrome is linked to mutations in the tumor suppressor gene that encodes the transcription factor p53, which plays a crucial role at the G1 checkpoint of the cell cycle. When damaged DNA is detected, p53 halts the progression of the cell cycle. As p53 levels rise, it triggers the production of p21, a protein that enforces the cell cycle arrest. Another form of Li-Fraumeni syndrome, known as LFS2, is believed to be caused by a mutation in the CHK2 gene, which also functions as a tumor suppressor. CHK2 regulates the activity of p53 in the cell cycle
  • a)
    prophase-metaphase-prometaphase-anaphase-telophase
  • b)
    cytokinesis-prometaphase-metaphase-anaphase-telophase
  • c)
    telophase-prometaphase-metaphase-anaphase-prophase
  • d)
    prophase-prometaphase-metaphase-anaphase-telophase
  • e)
    none of these
Correct answer is option 'B'. Can you explain this answer?

Ayesha Joshi answered
The specific order of stages in mitosis is consistently as follows: prophase, prometaphase, metaphase, anaphase, and telophase.

The method used to predict genotypic and phenotypic ratios of progeny from a genetic cross is called
  • a)
    Punnett square
  • b)
    Chi square
  • c)
    Friedman test
  • d)
    Paired t test
  • e)
    None of the above
Correct answer is option 'A'. Can you explain this answer?

Ayesha Joshi answered
The Punnett square is a method used to predict genotypic and phenotypic ratios of progeny resulting from a genetic cross. It is named after Reginald Punnett, an English geneticist who developed the square as a simple graphical tool to visualize the possible combinations of alleles from parental gametes. The Punnett square allows us to determine the probability of different genotypes and phenotypes in the offspring based on the known genotypes of the parents. It is widely used in genetics to study inheritance patterns and understand the potential outcomes of genetic crosses.

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