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All questions of Cell-Cell Interactions for MCAT Exam

The interaction between an antigen-presenting cell (APC) and a T cell is an example of:
  • a)
    Autocrine signaling
  • b)
    Paracrine signaling
  • c)
    Juxtacrine signaling
  • d)
    Contact-dependent signaling
Correct answer is option 'D'. Can you explain this answer?

Orion Classes answered
The interaction between an antigen-presenting cell (APC), such as a dendritic cell, and a T cell involves direct physical contact between the two cells. This interaction is necessary for the activation of T cells and the initiation of an immune response.

Gap junctions are specialized cell-cell junctions that allow for direct communication between cells through the exchange of:
  • a)
    Ions and small molecules
  • b)
    Proteins and lipids
  • c)
    Nucleic acids
  • d)
    Hormones and growth factors
Correct answer is option 'A'. Can you explain this answer?

Orion Classes answered
Gap junctions are formed by connexin proteins and allow for the direct transfer of ions and small molecules between adjacent cells. This communication allows cells to synchronize their activities and coordinate physiological processes.

Which of the following cell adhesion molecules plays a critical role in immune cell migration and extravasation?
  • a)
    Cadherins
  • b)
    Selectins
  • c)
    Integrins
  • d)
    Immunoglobulins
Correct answer is option 'C'. Can you explain this answer?

Orion Classes answered
Integrins are cell adhesion molecules that mediate interactions between cells and the extracellular matrix or other cells. In the context of immune cell migration, integrins are crucial for the process of extravasation, which involves immune cells leaving the bloodstream and entering tissues. Integrins on the surface of immune cells interact with adhesion molecules on endothelial cells lining blood vessels, facilitating their migration into tissues.

Which of the following is a mechanism of cell signaling that involves the release of chemical messengers into the bloodstream?
  • a)
    Paracrine signaling
  • b)
    Autocrine signaling
  • c)
    Endocrine signaling
  • d)
    Contact-dependent signaling
Correct answer is option 'C'. Can you explain this answer?

Orion Classes answered
Endocrine signaling involves the release of hormones into the bloodstream, where they travel to target cells located at distant sites in the body. This form of signaling allows for widespread and systemic communication within the body.

Which of the following is an example of direct cell-cell communication?
  • a)
    Paracrine signaling
  • b)
    Autocrine signaling
  • c)
    Endocrine signaling
  • d)
    Gap junctions
Correct answer is option 'D'. Can you explain this answer?

Orion Classes answered
Gap junctions are specialized channels that directly connect the cytoplasm of adjacent cells. These channels allow for the direct exchange of ions, small molecules, and electrical signals between cells. Gap junctions are found in many tissues and play a critical role in coordinating cellular activities and communication.

Cell signaling through G-protein coupled receptors (GPCRs) involves the activation of downstream signaling pathways through the interaction of the GPCR with:
  • a)
    Ligand-gated ion channels
  • b)
    Tyrosine kinase receptors
  • c)
    G-proteins
  • d)
    Integrins
Correct answer is option 'C'. Can you explain this answer?

Orion Classes answered
G-protein coupled receptors (GPCRs) are a large family of cell surface receptors that play a crucial role in cell signaling. When a ligand binds to the GPCR, it induces a conformational change that allows the receptor to interact with a G-protein. The activated G-protein then initiates intracellular signaling cascades, leading to various cellular responses.

In cell-cell interactions, the major histocompatibility complex (MHC) is responsible for:
  • a)
    Cell adhesion
  • b)
    Cell signaling
  • c)
    Antigen presentation
  • d)
    Cell migration
Correct answer is option 'C'. Can you explain this answer?

Orion Classes answered
The major histocompatibility complex (MHC) is a group of cell surface proteins that play a critical role in the immune system. MHC molecules are responsible for presenting antigens to T cells, which are key players in the immune response. Antigen presentation by MHC molecules helps activate T cells and initiate immune responses against pathogens or abnormal cells.

Which of the following is a major component of the extracellular matrix involved in cell adhesion?
  • a)
    Actin filaments
  • b)
    Collagen fibers
  • c)
    Microtubules
  • d)
    Intermediate filaments
Correct answer is option 'B'. Can you explain this answer?

Orion Classes answered
Collagen is a fibrous protein that forms the main structural component of the extracellular matrix. It provides strength and support to tissues and is involved in cell adhesion.

Cell adhesion molecules called cadherins are primarily involved in:
  • a)
    Cell migration
  • b)
    Cell signaling
  • c)
    Cell differentiation
  • d)
    Cell adhesion
Correct answer is option 'D'. Can you explain this answer?

Orion Classes answered
Cadherins are a family of cell adhesion molecules that mediate calcium-dependent cell-cell adhesion. They are responsible for the binding and adhesion of cells to each other, contributing to the formation and maintenance of tissue structure. Cadherins play a crucial role in embryonic development, tissue organization, and cell sorting.

Which of the following is a cell-cell interaction involved in immune responses, where a cell releases signaling molecules that act on nearby cells?
  • a)
    Paracrine signaling
  • b)
    Autocrine signaling
  • c)
    Juxtacrine signaling
  • d)
    Endocrine signaling
Correct answer is option 'A'. Can you explain this answer?

Orion Classes answered
Paracrine signaling involves the release of signaling molecules by a cell, which then act on nearby target cells. This form of cell-cell interaction is important in immune responses, as immune cells release cytokines and other signaling molecules that can stimulate or modulate the activities of neighboring immune cells, coordinating the immune response.

In the nervous system, cell-cell communication occurs through the release of neurotransmitters from the _______ and their binding to receptors on the _______.
  • a)
    Axons; dendrites
  • b)
    Dendrites; axons
  • c)
    Synaptic vesicles; presynaptic neuron
  • d)
    Postsynaptic neuron; presynaptic neuron
Correct answer is option 'C'. Can you explain this answer?

Orion Classes answered
In the nervous system, communication between neurons occurs at specialized junctions called synapses. Neurotransmitters are released from synaptic vesicles in the presynaptic neuron and bind to receptors on the postsynaptic neuron, facilitating the transmission of signals between neurons.

The formation of a synapse between a neuron and its target cell is an example of:
  • a)
    Autocrine signaling
  • b)
    Paracrine signaling
  • c)
    Endocrine signaling
  • d)
    Contact-dependent signaling
Correct answer is option 'D'. Can you explain this answer?

Orion Classes answered
Contact-dependent signaling involves direct physical contact between cells, where the signaling molecule on one cell interacts with its receptor on the adjacent cell. The formation of a synapse between a neuron and its target cell is a classic example of contact-dependent signaling, where the presynaptic neuron releases neurotransmitters that bind to receptors on the postsynaptic target cell.

Which of the following is an example of juxtacrine signaling?
  • a)
    Hormones released into the bloodstream
  • b)
    Neurotransmitters binding to receptors on target cells
  • c)
    Growth factors diffusing through the extracellular matrix
  • d)
    Ligands interacting with receptors on adjacent cells
Correct answer is option 'D'. Can you explain this answer?

Orion Classes answered
Juxtacrine signaling involves the direct interaction between signaling molecules (ligands) on one cell and receptors on an adjacent cell. This form of cell-cell communication requires close physical contact between the cells involved. Ligands are presented on the surface of one cell and bind to specific receptors on the neighboring cell, initiating intracellular signaling and communication.

The interaction between an antibody and an antigen is an example of:
  • a)
    Autocrine signaling
  • b)
    Paracrine signaling
  • c)
    Juxtacrine signaling
  • d)
    Contact-dependent signaling
Correct answer is option 'D'. Can you explain this answer?

Orion Classes answered
The interaction between an antibody and an antigen involves direct contact between the two molecules. Antibodies, produced by B cells, bind to specific antigens on pathogens or foreign substances, leading to their neutralization or targeting for destruction by other components of the immune system.

Tight junctions between epithelial cells primarily function to:
  • a)
    Facilitate cell-cell adhesion
  • b)
    Allow passage of ions and molecules between cells
  • c)
    Regulate the movement of substances across epithelial layers
  • d)
    Coordinate signaling between neighboring cells
Correct answer is option 'C'. Can you explain this answer?

Orion Classes answered
Tight junctions are specialized junctions between epithelial cells that form a barrier preventing the passage of substances between cells. They act as a seal and regulate the movement of molecules across epithelial layers, ensuring the selective transport of ions and molecules and maintaining the integrity and function of epithelial tissues.

The process by which white blood cells migrate from the bloodstream to infected tissues is known as:
  • a)
    Chemotaxis
  • b)
    Phagocytosis
  • c)
    Endocytosis
  • d)
    Exocytosis
Correct answer is option 'A'. Can you explain this answer?

Orion Classes answered
Chemotaxis refers to the directed movement of cells in response to chemical signals. In the context of the immune system, white blood cells exhibit chemotaxis during inflammation or infection. They are attracted by chemical signals, such as cytokines or microbial products, which guide them to the site of infection or tissue damage.

The Wnt signaling pathway is involved in the regulation of:
  • a)
    Cell proliferation and differentiation
  • b)
    Cell adhesion and migration
  • c)
    Apoptosis and cell death
  • d)
    Cellular metabolism and energy production
Correct answer is option 'A'. Can you explain this answer?

Orion Classes answered
The Wnt signaling pathway plays a crucial role in regulating cell proliferation and differentiation during development and tissue homeostasis. It is involved in various cellular processes, including embryonic development, stem cell maintenance, and tissue regeneration.

The Notch signaling pathway is an example of:
  • a)
    Autocrine signaling
  • b)
    Paracrine signaling
  • c)
    Juxtacrine signaling
  • d)
    Endocrine signaling
Correct answer is option 'C'. Can you explain this answer?

Orion Classes answered
Notch signaling involves direct cell-cell contact and interaction between the Notch receptor on one cell and the Delta ligand on the adjacent cell. This form of signaling is known as juxtacrine signaling.

Which of the following is a cell adhesion molecule involved in leukocyte extravasation during inflammation?
  • a)
    Cadherins
  • b)
    Selectins
  • c)
    Integrins
  • d)
    Immunoglobulins
Correct answer is option 'B'. Can you explain this answer?

Orion Classes answered
Selectins are cell adhesion molecules expressed on the surface of endothelial cells and leukocytes. They mediate the initial rolling and attachment of leukocytes to the endothelium during leukocyte extravasation, a process by which leukocytes leave the bloodstream and enter tissues.

Which of the following cell-cell adhesion molecules is involved in the formation of adherens junctions?
  • a)
    Cadherins
  • b)
    Integrins
  • c)
    Selectins
  • d)
    Immunoglobulins
Correct answer is option 'A'. Can you explain this answer?

Orion Classes answered
Cadherins are calcium-dependent cell adhesion molecules that play a key role in the formation of adherens junctions, which are cell-cell junctions involved in cell adhesion and tissue integrity.

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