Which of the following statement correctlydefines "Bohr effects&q...
As per Bohr's effect, a rise in pCO2 or a fall in pH increases the unloading of O2 from Hb.
Which of the following statement correctlydefines "Bohr effects&q...
Bohr effect refers to the phenomenon where the oxygen affinity of hemoglobin is decreased by an increase in carbon dioxide levels or a decrease in pH. This effect plays a crucial role in the release of oxygen from hemoglobin in tissues where oxygen demand is high.
Here is a detailed explanation of the correct definition of the Bohr effect:
- Rise in PCO2 with a decrease in pH: When the partial pressure of carbon dioxide (PCO2) increases in the blood, it leads to the formation of carbonic acid, which results in a decrease in pH. This decrease in pH is known as acidosis.
- Decrease in pH with an increase in PCO2: As the pH decreases, the affinity of hemoglobin for oxygen decreases as well. This means that hemoglobin releases oxygen more readily in tissues with higher carbon dioxide levels and lower pH, where oxygen is needed for cellular respiration.
- Bohr effect in action: During exercise, muscles produce more carbon dioxide and lactic acid, leading to a decrease in pH in the surrounding tissues. This triggers the Bohr effect, causing hemoglobin to release more oxygen to the muscle cells for energy production.
In summary, the Bohr effect describes the relationship between carbon dioxide levels, pH, and the oxygen-binding capacity of hemoglobin. A rise in PCO2 with a decrease in pH results in a decreased affinity of hemoglobin for oxygen, facilitating the release of oxygen to tissues where it is needed.
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