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Which of the following feature(s) should be present in a protein to generate strong immune response (antibody production) in an animal?
- a)At least one B-cell epitope
- b)At least one T-cell epitope
- c)Proteolytic cleavage site(s)
- d)Generation of a strong immune response depends on following factors and each of these are inter-related:
Correct answer is option 'A,B,C'. Can you explain this answer?
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Which of the following feature(s) should be present in a protein to ge...
a. At least one B-cell epitope. It will activate B-cell, induce clonal proliferation and help generate memoryB-cells and antibody secreting plasma cells.
b. At least one T-cell epitope. T-cells will be presented with the antigen on a self-MHC molecule. Only
when presented within antigens on board a self-MHC molecule, T-cells will be activated. These will
either secrete cytokines to support all other cell types respond well or kill the infected cell.
c. For antigen presentation, a protein antigen will be degraded to small peptides in host cells. This degradationinvolves enzymatic cleavage of protein into peptides. It is these peptides that bind to self-MHC and used for activating T-cells into generating an immune response.
Therefore, all 3 properties shall be present in a protein to generate a strong immune response against it
Most Upvoted Answer
Which of the following feature(s) should be present in a protein to ge...
Strong Immune Response in Proteins
To generate a strong immune response (antibody production) in an animal, a protein should possess the following features:
1. B-Cell Epitope
At least one B-cell epitope should be present in the protein. B-cell epitopes are regions of a protein that can bind to the antigen-binding site of an antibody. When a B-cell encounters an antigen with a B-cell epitope, it produces antibodies that can recognize and bind to that specific epitope. Therefore, the presence of B-cell epitopes in a protein is necessary to generate a strong immune response.
2. T-Cell Epitope
At least one T-cell epitope should be present in the protein. T-cell epitopes are small peptides that can be presented to T-cells by antigen-presenting cells. T-cells are important in the immune response because they can activate other immune cells such as B-cells and macrophages. Therefore, the presence of T-cell epitopes in a protein is also necessary to generate a strong immune response.
3. Proteolytic Cleavage Sites
Proteolytic cleavage sites should be present in the protein. Proteolytic cleavage sites are regions of a protein that can be recognized and cleaved by proteases. Proteases are enzymes that can break down proteins into smaller peptides. Proteolytic cleavage of a protein can generate new epitopes that can be recognized by B-cells and T-cells, leading to a stronger immune response.
4. Factors Influencing Immune Response
The generation of a strong immune response depends on several factors that are inter-related, including the antigen dose, route of administration, adjuvants, and host factors such as age, genetics, and immune status. These factors can affect the magnitude and quality of the immune response, and therefore, should be considered when designing vaccines or immunotherapies.
In summary, to generate a strong immune response in an animal, a protein should possess at least one B-cell epitope, at least one T-cell epitope, and proteolytic cleavage sites. Additionally, several factors can influence the immune response and should be considered in the design of vaccines or immunotherapies.
To generate a strong immune response (antibody production) in an animal, a protein should possess the following features:
1. B-Cell Epitope
At least one B-cell epitope should be present in the protein. B-cell epitopes are regions of a protein that can bind to the antigen-binding site of an antibody. When a B-cell encounters an antigen with a B-cell epitope, it produces antibodies that can recognize and bind to that specific epitope. Therefore, the presence of B-cell epitopes in a protein is necessary to generate a strong immune response.
2. T-Cell Epitope
At least one T-cell epitope should be present in the protein. T-cell epitopes are small peptides that can be presented to T-cells by antigen-presenting cells. T-cells are important in the immune response because they can activate other immune cells such as B-cells and macrophages. Therefore, the presence of T-cell epitopes in a protein is also necessary to generate a strong immune response.
3. Proteolytic Cleavage Sites
Proteolytic cleavage sites should be present in the protein. Proteolytic cleavage sites are regions of a protein that can be recognized and cleaved by proteases. Proteases are enzymes that can break down proteins into smaller peptides. Proteolytic cleavage of a protein can generate new epitopes that can be recognized by B-cells and T-cells, leading to a stronger immune response.
4. Factors Influencing Immune Response
The generation of a strong immune response depends on several factors that are inter-related, including the antigen dose, route of administration, adjuvants, and host factors such as age, genetics, and immune status. These factors can affect the magnitude and quality of the immune response, and therefore, should be considered when designing vaccines or immunotherapies.
In summary, to generate a strong immune response in an animal, a protein should possess at least one B-cell epitope, at least one T-cell epitope, and proteolytic cleavage sites. Additionally, several factors can influence the immune response and should be considered in the design of vaccines or immunotherapies.
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Which of the following feature(s) should be present in a protein to generate strong immune response (antibody production) in an animal?a)At least one B-cell epitopeb)At least one T-cell epitopec)Proteolytic cleavage site(s)d)Generation of a strong immune response depends on following factors and each of these are inter-related:Correct answer is option 'A,B,C'. Can you explain this answer?
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Which of the following feature(s) should be present in a protein to generate strong immune response (antibody production) in an animal?a)At least one B-cell epitopeb)At least one T-cell epitopec)Proteolytic cleavage site(s)d)Generation of a strong immune response depends on following factors and each of these are inter-related:Correct answer is option 'A,B,C'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Which of the following feature(s) should be present in a protein to generate strong immune response (antibody production) in an animal?a)At least one B-cell epitopeb)At least one T-cell epitopec)Proteolytic cleavage site(s)d)Generation of a strong immune response depends on following factors and each of these are inter-related:Correct answer is option 'A,B,C'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Which of the following feature(s) should be present in a protein to generate strong immune response (antibody production) in an animal?a)At least one B-cell epitopeb)At least one T-cell epitopec)Proteolytic cleavage site(s)d)Generation of a strong immune response depends on following factors and each of these are inter-related:Correct answer is option 'A,B,C'. Can you explain this answer?.
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