Explanation:

Nucleotide biosynthesis is a complex process that involves the synthesis of nucleotides, the building blocks of DNA and RNA. These nucleotides are composed of three components: a nitrogenous base, a sugar molecule, and a phosphate group. The nitrogenous bases can be either purines (adenine and guanine) or pyrimidines (cytosine, thymine, and uracil).

Role of amino acids:

Amino acids play a crucial role in nucleotide biosynthesis as they are involved in the synthesis of various components of nucleotides. Some amino acids are directly involved in the synthesis of the nitrogenous bases, while others are required for the synthesis of the sugar molecule or the phosphate group.

Analysis of options:

a) Histidine: Histidine is an essential amino acid that is not directly involved in the synthesis of nucleotides. It is not required for the synthesis of any component of nucleotides.

b) Glycine: Glycine is a non-essential amino acid that is involved in the synthesis of purines, which are one of the nitrogenous bases found in nucleotides. It is required for nucleotide biosynthesis.

c) Glutamine: Glutamine is a non-essential amino acid that is involved in the synthesis of purines and pyrimidines, which are the nitrogenous bases found in nucleotides. It is required for nucleotide biosynthesis.

d) Aspartate: Aspartate is a non-essential amino acid that is involved in the synthesis of pyrimidines, which are one of the nitrogenous bases found in nucleotides. It is required for nucleotide biosynthesis.

Conclusion:

Based on the analysis, the amino acid histidine is not needed for nucleotide biosynthesis. The other amino acids (glycine, glutamine, and aspartate) are all required for the synthesis of nucleotides or their components.