Which of the following combinations represent the correct set of charge on different phospholipids [PC: phosphotidylcholine; PS: Phosphotidylserine, PE: Phosphotidylethanolamine, CL: cardiolipin]a)PC : 1 ; PS: 1 ; PE: 0 ; CL: 0b)PC : -1 ; PS: 1 ; PE: 1 ; CL: -2c)PC : 0 ; PS: 1 ; PE: 0 ; CL: -2d)PC : 0 ; PS: -1 ; PE: 0 ; CL: -2Correct answer is option 'D'. Can you explain this answer?

Question

Answer

Explanation:

In order to determine the correct set of charges on different phospholipids, we need to consider the structure of each phospholipid molecule and the charges associated with the different components.

Phosphotidylcholine (PC):
- Phosphotidylcholine consists of a choline molecule attached to a phosphate group, which is in turn attached to a glycerol backbone.
- The choline molecule has a quaternary ammonium group, which carries a positive charge.
- Therefore, the charge on PC is 0.

Phosphotidylserine (PS):
- Phosphotidylserine also consists of a phosphate group attached to a glycerol backbone.
- However, in PS, the phosphate group is esterified to the serine molecule.
- The serine molecule has a carboxyl group, which carries a negative charge at physiological pH.
- Therefore, the charge on PS is -1.

Phosphotidylethanolamine (PE):
- Phosphotidylethanolamine also consists of a phosphate group attached to a glycerol backbone.
- In PE, the phosphate group is esterified to the ethanolamine molecule.
- Ethanolamine does not have any charged groups.
- Therefore, the charge on PE is 0.

Cardiolipin (CL):
- Cardiolipin is a unique phospholipid found in the inner mitochondrial membrane.
- It consists of two phosphatidylglycerol molecules connected by a glycerol bridge.
- Each phosphatidylglycerol molecule has a phosphate group attached to a glycerol backbone.
- The charge on cardiolipin can vary depending on the specific fatty acids attached to the glycerol backbone.
- However, in general, cardiolipin is considered to have a charge of -2.

Correct Set of Charges:
Based on the above information, the correct set of charges on different phospholipids is:

PC: 0
PS: -1
PE: 0
CL: -2

Therefore, option D is the correct answer.

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