200 individuals in a population carry the mutant alleles. However, onl...
Penetrance is the percent of people showing the phenotypes.
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200 individuals in a population carry the mutant alleles. However, onl...
Penetrance refers to the proportion of individuals carrying a specific genotype who actually display the associated phenotype. In this case, there are 200 individuals in the population who carry the mutant alleles, but only 160 individuals show the mutant phenotype. To calculate the penetrance of the mutant allele, we need to divide the number of individuals with the mutant phenotype by the total number of individuals with the mutant alleles and then multiply by 100 to express it as a percentage.
Given:
- Total number of individuals with the mutant alleles (genotype) = 200
- Number of individuals showing the mutant phenotype = 160
To calculate the penetrance:
1. Determine the proportion of individuals with the mutant phenotype:
- Proportion = Number of individuals with the mutant phenotype / Total number of individuals with the mutant alleles
- Proportion = 160 / 200 = 0.8
2. Convert the proportion to a percentage:
- Percentage = Proportion * 100
- Percentage = 0.8 * 100 = 80
Therefore, the penetrance of the mutant allele in the population is 80%.
This means that out of the 200 individuals carrying the mutant alleles, 80% of them actually display the mutant phenotype, while the remaining 20% do not show any signs of the mutant phenotype despite carrying the mutant alleles.
It is important to note that penetrance can vary depending on various factors such as genetic modifiers, environmental factors, and interactions with other genes. In this case, since the penetrance is given as 80%, it suggests that the mutant allele has a relatively high penetrance in the population, meaning that a large proportion of individuals with the mutant alleles show the associated phenotype.