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Based on the behavior of the metalloenzymes, choose the correct statement(s):           
  • a)
    In the enzymes, the zinc-activates O2 to form peroxide species.           
  • b)
    In the enzymes, the zinc activates H2O and provides a zinc bound hydroxide           
  • c)
    In the oxidases, the iron activates O2 to break the bonding between the two oxygens           
  • d)
    Zinc ion acts as a nucleophile and attacks at the peptide carbonyl
Correct answer is option 'B,C'. Can you explain this answer?
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Based on the behavior of the metalloenzymes, choose the correct statem...
Metalloenzymes and their behavior

Metalloenzymes are enzymes that contain metal ions in their active site, which are essential for their catalytic activity. The behavior of metalloenzymes is dependent on the type of metal ion present in their active site and the nature of the reaction that they catalyze.

Zinc activation of H2O

In metalloenzymes such as carbonic anhydrase, the zinc ion activates water molecules and provides a zinc-bound hydroxide ion that can attack the substrate. This mechanism is important for the rapid conversion of CO2 to bicarbonate in the blood, which helps to maintain the pH balance of the body.

Iron activation of O2

In metalloenzymes such as cytochrome c oxidase, the iron ion activates oxygen molecules and breaks the bonding between the two oxygens. This mechanism is important for the final step in the electron transport chain, where oxygen is reduced to water and energy is produced.

Zinc attacks at peptide carbonyl

Zinc ion acts as a nucleophile and attacks at the peptide carbonyl in metalloenzymes such as carboxypeptidase. This mechanism is important for the hydrolysis of peptide bonds and the removal of amino acid residues from the C-terminus of a peptide chain.

Conclusion

In conclusion, metalloenzymes exhibit a variety of behaviors depending on the type of metal ion present in their active site and the nature of the reaction that they catalyze. Zinc activation of water molecules and iron activation of oxygen molecules are important mechanisms for catalysis in metalloenzymes. Zinc ion can also act as a nucleophile and attack peptide carbonyls in certain metalloenzymes.
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Based on the behavior of the metalloenzymes, choose the correct statement(s):a)In the enzymes, the zinc-activates O2 to form peroxide species.b)In the enzymes, the zinc activates H2O and provides a zinc bound hydroxidec)In the oxidases, the iron activates O2 to break the bonding between the two oxygensd)Zinc ion acts as a nucleophile and attacks at the peptide carbonylCorrect answer is option 'B,C'. Can you explain this answer?
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Based on the behavior of the metalloenzymes, choose the correct statement(s):a)In the enzymes, the zinc-activates O2 to form peroxide species.b)In the enzymes, the zinc activates H2O and provides a zinc bound hydroxidec)In the oxidases, the iron activates O2 to break the bonding between the two oxygensd)Zinc ion acts as a nucleophile and attacks at the peptide carbonylCorrect answer is option 'B,C'. Can you explain this answer? for Chemistry 2024 is part of Chemistry preparation. The Question and answers have been prepared according to the Chemistry exam syllabus. Information about Based on the behavior of the metalloenzymes, choose the correct statement(s):a)In the enzymes, the zinc-activates O2 to form peroxide species.b)In the enzymes, the zinc activates H2O and provides a zinc bound hydroxidec)In the oxidases, the iron activates O2 to break the bonding between the two oxygensd)Zinc ion acts as a nucleophile and attacks at the peptide carbonylCorrect answer is option 'B,C'. Can you explain this answer? covers all topics & solutions for Chemistry 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Based on the behavior of the metalloenzymes, choose the correct statement(s):a)In the enzymes, the zinc-activates O2 to form peroxide species.b)In the enzymes, the zinc activates H2O and provides a zinc bound hydroxidec)In the oxidases, the iron activates O2 to break the bonding between the two oxygensd)Zinc ion acts as a nucleophile and attacks at the peptide carbonylCorrect answer is option 'B,C'. Can you explain this answer?.
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