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Group QuestionThe passage given below is followed by a set of questions. Choose the most appropriate answer to each question.Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to synthesize DNA bases (most notably thymine, but also purine bases) needed for DNA replication. Thus folate deficiency hinders DNA synthesis and cell division, affecting most notably bone marrow and cancer, both of which participate in rapid cell division. RNA transcriptions, and subsequent protein synthesis, are less affected by folate deficiency as the mRNA can be recycled and used again (as opposed to DNA synthesis where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells (RBCs) is hindered and leads to megaloblastic anaemia which is characterized by large immature RBCs. This pathology results in persistently thwarted attempts at normal DNA replication, DNA repair, and cell division and produces abnormally large cells (megaloblasts) with abundant cytoplasm capable of RNA and protein synthesis but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature, are released early from the marrow in an attempt to compensate for the anaemia caused by lack of RBCs. Both adults and children need folate to make normal RBCs and prevent anaemia. Deficiency of folate in pregnant women has been implicated in neural tube birth defects; therefore, many cereals sold in developed countries are enriched with folate to avoid such complications.There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anaemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (1000 pg or 1 mg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.In fact, to date the evidence that such masking actually occurs is scarce, and there is no evidence that folic acid fortification in Canada or the US has increased the prevalence of vitamin B12 deficiency or its consequences.However one recent study has demonstrated that high folic or folate levels when combined with low B12 levels are associated with significant cognitive impairment among the elderly. If the observed relationship for seniors between folic acid intake, B12 levels, and cognitive impairment is replicated and confirmed, this is likely to re-open the debate on folic acid fortification in food, even though public health policies tend generally to support the developmentalneeds of infants and children over slight risks to other population groups. In any case, it is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.Q.Which of the following is indicated in the passage?A. Folates deficiency, hindering cell division, affects bone marrow and cancer.B. Vitamin B^and folic acid often correct deficiencies caused by the others levels in the human system.C. Health concerns especially relating with cognitive impairment have increased the research about folates.a)Both A and Bb)Either A or Bc)B onlyd)A onlyCorrect answer is option 'D'. Can you explain this answer? for CAT 2024 is part of CAT preparation. The Question and answers have been prepared according to the CAT exam syllabus. Information about Group QuestionThe passage given below is followed by a set of questions. Choose the most appropriate answer to each question.Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to synthesize DNA bases (most notably thymine, but also purine bases) needed for DNA replication. Thus folate deficiency hinders DNA synthesis and cell division, affecting most notably bone marrow and cancer, both of which participate in rapid cell division. RNA transcriptions, and subsequent protein synthesis, are less affected by folate deficiency as the mRNA can be recycled and used again (as opposed to DNA synthesis where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells (RBCs) is hindered and leads to megaloblastic anaemia which is characterized by large immature RBCs. This pathology results in persistently thwarted attempts at normal DNA replication, DNA repair, and cell division and produces abnormally large cells (megaloblasts) with abundant cytoplasm capable of RNA and protein synthesis but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature, are released early from the marrow in an attempt to compensate for the anaemia caused by lack of RBCs. Both adults and children need folate to make normal RBCs and prevent anaemia. Deficiency of folate in pregnant women has been implicated in neural tube birth defects; therefore, many cereals sold in developed countries are enriched with folate to avoid such complications.There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anaemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (1000 pg or 1 mg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.In fact, to date the evidence that such masking actually occurs is scarce, and there is no evidence that folic acid fortification in Canada or the US has increased the prevalence of vitamin B12 deficiency or its consequences.However one recent study has demonstrated that high folic or folate levels when combined with low B12 levels are associated with significant cognitive impairment among the elderly. If the observed relationship for seniors between folic acid intake, B12 levels, and cognitive impairment is replicated and confirmed, this is likely to re-open the debate on folic acid fortification in food, even though public health policies tend generally to support the developmentalneeds of infants and children over slight risks to other population groups. In any case, it is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.Q.Which of the following is indicated in the passage?A. Folates deficiency, hindering cell division, affects bone marrow and cancer.B. Vitamin B^and folic acid often correct deficiencies caused by the others levels in the human system.C. Health concerns especially relating with cognitive impairment have increased the research about folates.a)Both A and Bb)Either A or Bc)B onlyd)A onlyCorrect answer is option 'D'. Can you explain this answer? covers all topics & solutions for CAT 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Group QuestionThe passage given below is followed by a set of questions. Choose the most appropriate answer to each question.Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to synthesize DNA bases (most notably thymine, but also purine bases) needed for DNA replication. Thus folate deficiency hinders DNA synthesis and cell division, affecting most notably bone marrow and cancer, both of which participate in rapid cell division. RNA transcriptions, and subsequent protein synthesis, are less affected by folate deficiency as the mRNA can be recycled and used again (as opposed to DNA synthesis where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells (RBCs) is hindered and leads to megaloblastic anaemia which is characterized by large immature RBCs. This pathology results in persistently thwarted attempts at normal DNA replication, DNA repair, and cell division and produces abnormally large cells (megaloblasts) with abundant cytoplasm capable of RNA and protein synthesis but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature, are released early from the marrow in an attempt to compensate for the anaemia caused by lack of RBCs. Both adults and children need folate to make normal RBCs and prevent anaemia. Deficiency of folate in pregnant women has been implicated in neural tube birth defects; therefore, many cereals sold in developed countries are enriched with folate to avoid such complications.There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anaemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (1000 pg or 1 mg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.In fact, to date the evidence that such masking actually occurs is scarce, and there is no evidence that folic acid fortification in Canada or the US has increased the prevalence of vitamin B12 deficiency or its consequences.However one recent study has demonstrated that high folic or folate levels when combined with low B12 levels are associated with significant cognitive impairment among the elderly. If the observed relationship for seniors between folic acid intake, B12 levels, and cognitive impairment is replicated and confirmed, this is likely to re-open the debate on folic acid fortification in food, even though public health policies tend generally to support the developmentalneeds of infants and children over slight risks to other population groups. In any case, it is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.Q.Which of the following is indicated in the passage?A. Folates deficiency, hindering cell division, affects bone marrow and cancer.B. Vitamin B^and folic acid often correct deficiencies caused by the others levels in the human system.C. Health concerns especially relating with cognitive impairment have increased the research about folates.a)Both A and Bb)Either A or Bc)B onlyd)A onlyCorrect answer is option 'D'. Can you explain this answer?.

Solutions for Group QuestionThe passage given below is followed by a set of questions. Choose the most appropriate answer to each question.Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to synthesize DNA bases (most notably thymine, but also purine bases) needed for DNA replication. Thus folate deficiency hinders DNA synthesis and cell division, affecting most notably bone marrow and cancer, both of which participate in rapid cell division. RNA transcriptions, and subsequent protein synthesis, are less affected by folate deficiency as the mRNA can be recycled and used again (as opposed to DNA synthesis where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells (RBCs) is hindered and leads to megaloblastic anaemia which is characterized by large immature RBCs. This pathology results in persistently thwarted attempts at normal DNA replication, DNA repair, and cell division and produces abnormally large cells (megaloblasts) with abundant cytoplasm capable of RNA and protein synthesis but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature, are released early from the marrow in an attempt to compensate for the anaemia caused by lack of RBCs. Both adults and children need folate to make normal RBCs and prevent anaemia. Deficiency of folate in pregnant women has been implicated in neural tube birth defects; therefore, many cereals sold in developed countries are enriched with folate to avoid such complications.There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anaemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (1000 pg or 1 mg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.In fact, to date the evidence that such masking actually occurs is scarce, and there is no evidence that folic acid fortification in Canada or the US has increased the prevalence of vitamin B12 deficiency or its consequences.However one recent study has demonstrated that high folic or folate levels when combined with low B12 levels are associated with significant cognitive impairment among the elderly. If the observed relationship for seniors between folic acid intake, B12 levels, and cognitive impairment is replicated and confirmed, this is likely to re-open the debate on folic acid fortification in food, even though public health policies tend generally to support the developmentalneeds of infants and children over slight risks to other population groups. In any case, it is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.Q.Which of the following is indicated in the passage?A. Folates deficiency, hindering cell division, affects bone marrow and cancer.B. Vitamin B^and folic acid often correct deficiencies caused by the others levels in the human system.C. Health concerns especially relating with cognitive impairment have increased the research about folates.a)Both A and Bb)Either A or Bc)B onlyd)A onlyCorrect answer is option 'D'. Can you explain this answer? in English & in Hindi are available as part of our courses for CAT. Download more important topics, notes, lectures and mock test series for CAT Exam by signing up for free.

Here you can find the meaning of Group QuestionThe passage given below is followed by a set of questions. Choose the most appropriate answer to each question.Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to synthesize DNA bases (most notably thymine, but also purine bases) needed for DNA replication. Thus folate deficiency hinders DNA synthesis and cell division, affecting most notably bone marrow and cancer, both of which participate in rapid cell division. RNA transcriptions, and subsequent protein synthesis, are less affected by folate deficiency as the mRNA can be recycled and used again (as opposed to DNA synthesis where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells (RBCs) is hindered and leads to megaloblastic anaemia which is characterized by large immature RBCs. This pathology results in persistently thwarted attempts at normal DNA replication, DNA repair, and cell division and produces abnormally large cells (megaloblasts) with abundant cytoplasm capable of RNA and protein synthesis but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature, are released early from the marrow in an attempt to compensate for the anaemia caused by lack of RBCs. Both adults and children need folate to make normal RBCs and prevent anaemia. Deficiency of folate in pregnant women has been implicated in neural tube birth defects; therefore, many cereals sold in developed countries are enriched with folate to avoid such complications.There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anaemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (1000 pg or 1 mg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.In fact, to date the evidence that such masking actually occurs is scarce, and there is no evidence that folic acid fortification in Canada or the US has increased the prevalence of vitamin B12 deficiency or its consequences.However one recent study has demonstrated that high folic or folate levels when combined with low B12 levels are associated with significant cognitive impairment among the elderly. If the observed relationship for seniors between folic acid intake, B12 levels, and cognitive impairment is replicated and confirmed, this is likely to re-open the debate on folic acid fortification in food, even though public health policies tend generally to support the developmentalneeds of infants and children over slight risks to other population groups. In any case, it is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.Q.Which of the following is indicated in the passage?A. Folates deficiency, hindering cell division, affects bone marrow and cancer.B. Vitamin B^and folic acid often correct deficiencies caused by the others levels in the human system.C. Health concerns especially relating with cognitive impairment have increased the research about folates.a)Both A and Bb)Either A or Bc)B onlyd)A onlyCorrect answer is option 'D'. Can you explain this answer? defined & explained in the simplest way possible. Besides giving the explanation of Group QuestionThe passage given below is followed by a set of questions. Choose the most appropriate answer to each question.Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to synthesize DNA bases (most notably thymine, but also purine bases) needed for DNA replication. Thus folate deficiency hinders DNA synthesis and cell division, affecting most notably bone marrow and cancer, both of which participate in rapid cell division. RNA transcriptions, and subsequent protein synthesis, are less affected by folate deficiency as the mRNA can be recycled and used again (as opposed to DNA synthesis where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells (RBCs) is hindered and leads to megaloblastic anaemia which is characterized by large immature RBCs. This pathology results in persistently thwarted attempts at normal DNA replication, DNA repair, and cell division and produces abnormally large cells (megaloblasts) with abundant cytoplasm capable of RNA and protein synthesis but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature, are released early from the marrow in an attempt to compensate for the anaemia caused by lack of RBCs. Both adults and children need folate to make normal RBCs and prevent anaemia. Deficiency of folate in pregnant women has been implicated in neural tube birth defects; therefore, many cereals sold in developed countries are enriched with folate to avoid such complications.There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anaemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (1000 pg or 1 mg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.In fact, to date the evidence that such masking actually occurs is scarce, and there is no evidence that folic acid fortification in Canada or the US has increased the prevalence of vitamin B12 deficiency or its consequences.However one recent study has demonstrated that high folic or folate levels when combined with low B12 levels are associated with significant cognitive impairment among the elderly. If the observed relationship for seniors between folic acid intake, B12 levels, and cognitive impairment is replicated and confirmed, this is likely to re-open the debate on folic acid fortification in food, even though public health policies tend generally to support the developmentalneeds of infants and children over slight risks to other population groups. In any case, it is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.Q.Which of the following is indicated in the passage?A. Folates deficiency, hindering cell division, affects bone marrow and cancer.B. Vitamin B^and folic acid often correct deficiencies caused by the others levels in the human system.C. Health concerns especially relating with cognitive impairment have increased the research about folates.a)Both A and Bb)Either A or Bc)B onlyd)A onlyCorrect answer is option 'D'. Can you explain this answer?, a detailed solution for Group QuestionThe passage given below is followed by a set of questions. Choose the most appropriate answer to each question.Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to synthesize DNA bases (most notably thymine, but also purine bases) needed for DNA replication. Thus folate deficiency hinders DNA synthesis and cell division, affecting most notably bone marrow and cancer, both of which participate in rapid cell division. RNA transcriptions, and subsequent protein synthesis, are less affected by folate deficiency as the mRNA can be recycled and used again (as opposed to DNA synthesis where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells (RBCs) is hindered and leads to megaloblastic anaemia which is characterized by large immature RBCs. This pathology results in persistently thwarted attempts at normal DNA replication, DNA repair, and cell division and produces abnormally large cells (megaloblasts) with abundant cytoplasm capable of RNA and protein synthesis but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature, are released early from the marrow in an attempt to compensate for the anaemia caused by lack of RBCs. Both adults and children need folate to make normal RBCs and prevent anaemia. Deficiency of folate in pregnant women has been implicated in neural tube birth defects; therefore, many cereals sold in developed countries are enriched with folate to avoid such complications.There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anaemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (1000 pg or 1 mg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.In fact, to date the evidence that such masking actually occurs is scarce, and there is no evidence that folic acid fortification in Canada or the US has increased the prevalence of vitamin B12 deficiency or its consequences.However one recent study has demonstrated that high folic or folate levels when combined with low B12 levels are associated with significant cognitive impairment among the elderly. If the observed relationship for seniors between folic acid intake, B12 levels, and cognitive impairment is replicated and confirmed, this is likely to re-open the debate on folic acid fortification in food, even though public health policies tend generally to support the developmentalneeds of infants and children over slight risks to other population groups. In any case, it is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.Q.Which of the following is indicated in the passage?A. Folates deficiency, hindering cell division, affects bone marrow and cancer.B. Vitamin B^and folic acid often correct deficiencies caused by the others levels in the human system.C. Health concerns especially relating with cognitive impairment have increased the research about folates.a)Both A and Bb)Either A or Bc)B onlyd)A onlyCorrect answer is option 'D'. Can you explain this answer? has been provided alongside types of Group QuestionThe passage given below is followed by a set of questions. Choose the most appropriate answer to each question.Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to synthesize DNA bases (most notably thymine, but also purine bases) needed for DNA replication. Thus folate deficiency hinders DNA synthesis and cell division, affecting most notably bone marrow and cancer, both of which participate in rapid cell division. RNA transcriptions, and subsequent protein synthesis, are less affected by folate deficiency as the mRNA can be recycled and used again (as opposed to DNA synthesis where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells (RBCs) is hindered and leads to megaloblastic anaemia which is characterized by large immature RBCs. This pathology results in persistently thwarted attempts at normal DNA replication, DNA repair, and cell division and produces abnormally large cells (megaloblasts) with abundant cytoplasm capable of RNA and protein synthesis but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature, are released early from the marrow in an attempt to compensate for the anaemia caused by lack of RBCs. Both adults and children need folate to make normal RBCs and prevent anaemia. Deficiency of folate in pregnant women has been implicated in neural tube birth defects; therefore, many cereals sold in developed countries are enriched with folate to avoid such complications.There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anaemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (1000 pg or 1 mg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.In fact, to date the evidence that such masking actually occurs is scarce, and there is no evidence that folic acid fortification in Canada or the US has increased the prevalence of vitamin B12 deficiency or its consequences.However one recent study has demonstrated that high folic or folate levels when combined with low B12 levels are associated with significant cognitive impairment among the elderly. If the observed relationship for seniors between folic acid intake, B12 levels, and cognitive impairment is replicated and confirmed, this is likely to re-open the debate on folic acid fortification in food, even though public health policies tend generally to support the developmentalneeds of infants and children over slight risks to other population groups. In any case, it is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.Q.Which of the following is indicated in the passage?A. Folates deficiency, hindering cell division, affects bone marrow and cancer.B. Vitamin B^and folic acid often correct deficiencies caused by the others levels in the human system.C. Health concerns especially relating with cognitive impairment have increased the research about folates.a)Both A and Bb)Either A or Bc)B onlyd)A onlyCorrect answer is option 'D'. Can you explain this answer? theory, EduRev gives you an ample number of questions to practice Group QuestionThe passage given below is followed by a set of questions. Choose the most appropriate answer to each question.Folate is necessary for the production and maintenance of new cells. This is especially important during periods of rapid cell division and growth such as infancy and pregnancy. Folate is needed to synthesize DNA bases (most notably thymine, but also purine bases) needed for DNA replication. Thus folate deficiency hinders DNA synthesis and cell division, affecting most notably bone marrow and cancer, both of which participate in rapid cell division. RNA transcriptions, and subsequent protein synthesis, are less affected by folate deficiency as the mRNA can be recycled and used again (as opposed to DNA synthesis where a new genomic copy must be created). Since folate deficiency limits cell division, erythropoiesis, production of red blood cells (RBCs) is hindered and leads to megaloblastic anaemia which is characterized by large immature RBCs. This pathology results in persistently thwarted attempts at normal DNA replication, DNA repair, and cell division and produces abnormally large cells (megaloblasts) with abundant cytoplasm capable of RNA and protein synthesis but with clumping and fragmentation of nuclear chromatin. Some of these large cells, although immature, are released early from the marrow in an attempt to compensate for the anaemia caused by lack of RBCs. Both adults and children need folate to make normal RBCs and prevent anaemia. Deficiency of folate in pregnant women has been implicated in neural tube birth defects; therefore, many cereals sold in developed countries are enriched with folate to avoid such complications.There has been concern about the interaction between vitamin B12 and folic acid. Folic acid supplements can correct the anaemia associated with vitamin B12 deficiency. Unfortunately, folic acid will not correct changes in the nervous system that result from vitamin B12 deficiency. Permanent nerve damage could theoretically occur if vitamin B12 deficiency is not treated. Therefore, intake of supplemental folic acid should not exceed 1000 micrograms (1000 pg or 1 mg) per day to prevent folic acid from masking symptoms of vitamin B12 deficiency.In fact, to date the evidence that such masking actually occurs is scarce, and there is no evidence that folic acid fortification in Canada or the US has increased the prevalence of vitamin B12 deficiency or its consequences.However one recent study has demonstrated that high folic or folate levels when combined with low B12 levels are associated with significant cognitive impairment among the elderly. If the observed relationship for seniors between folic acid intake, B12 levels, and cognitive impairment is replicated and confirmed, this is likely to re-open the debate on folic acid fortification in food, even though public health policies tend generally to support the developmentalneeds of infants and children over slight risks to other population groups. In any case, it is important for older adults to be aware of the relationship between folic acid and vitamin B12 because they are at greater risk of having a vitamin B12 deficiency. If you are 50 years of age or older, ask your physician to check your B12 status before you take a supplement that contains folic acid.Q.Which of the following is indicated in the passage?A. Folates deficiency, hindering cell division, affects bone marrow and cancer.B. Vitamin B^and folic acid often correct deficiencies caused by the others levels in the human system.C. Health concerns especially relating with cognitive impairment have increased the research about folates.a)Both A and Bb)Either A or Bc)B onlyd)A onlyCorrect answer is option 'D'. Can you explain this answer? tests, examples and also practice CAT tests.