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Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.
- a)Only one strand needs to be cut
- b)Both strands have to be cut
- c)No strand needs to be cut
- d)ATP is required for inter-conversion
Correct answer is option 'A,B,D'. Can you explain this answer?
Most Upvoted Answer
Pick the correct statement(s) with respect to the inter-conversion of ...
Because for proper replication of DNA,both strands neet to be separated with the help of various enzymes,topoisomerase ensures to open up the double helical structure for duplication of DNA and again put it back to tge double stranded structure
Community Answer
Pick the correct statement(s) with respect to the inter-conversion of ...
Inter-conversion of topoisomers of circularly closed double stranded DNA
Inter-conversion of topoisomers refers to the alteration of the topology of DNA molecules, specifically circularly closed double stranded DNA. Topoisomerases are enzymes that facilitate these changes by introducing or removing DNA supercoils. There are two types of topoisomerases: topoisomerase I and topoisomerase II. Topoisomerase I introduces transient single-strand breaks, while topoisomerase II introduces transient double-strand breaks.
Statement Analysis
a) Only one strand needs to be cut
This statement is correct. Topoisomerase I can introduce a transient single-strand break in one of the DNA strands to allow the passage of the other DNA strand through the break. This process helps in the relaxation of negative supercoils or the introduction of negative supercoils.
b) Both strands have to be cut
This statement is correct. Topoisomerase II can introduce transient double-strand breaks in both DNA strands. This allows the passage of another DNA duplex through the break, resulting in the relaxation of positive supercoils or the introduction of positive supercoils.
c) No strand needs to be cut
This statement is incorrect. In order to change the topology of circularly closed double stranded DNA, at least one strand needs to be cut. This is done by topoisomerases to facilitate the inter-conversion of topoisomers.
d) ATP is required for inter-conversion
This statement is correct. ATP is required for the inter-conversion of topoisomers. Topoisomerases use ATP hydrolysis to provide the energy necessary for the strand breakage and rejoining reactions.
Conclusion
Based on the analysis, the correct statements with respect to the inter-conversion of topoisomers of circularly closed double stranded DNA are:
- Only one strand needs to be cut
- Both strands have to be cut
- ATP is required for inter-conversion
Inter-conversion of topoisomers refers to the alteration of the topology of DNA molecules, specifically circularly closed double stranded DNA. Topoisomerases are enzymes that facilitate these changes by introducing or removing DNA supercoils. There are two types of topoisomerases: topoisomerase I and topoisomerase II. Topoisomerase I introduces transient single-strand breaks, while topoisomerase II introduces transient double-strand breaks.
Statement Analysis
a) Only one strand needs to be cut
This statement is correct. Topoisomerase I can introduce a transient single-strand break in one of the DNA strands to allow the passage of the other DNA strand through the break. This process helps in the relaxation of negative supercoils or the introduction of negative supercoils.
b) Both strands have to be cut
This statement is correct. Topoisomerase II can introduce transient double-strand breaks in both DNA strands. This allows the passage of another DNA duplex through the break, resulting in the relaxation of positive supercoils or the introduction of positive supercoils.
c) No strand needs to be cut
This statement is incorrect. In order to change the topology of circularly closed double stranded DNA, at least one strand needs to be cut. This is done by topoisomerases to facilitate the inter-conversion of topoisomers.
d) ATP is required for inter-conversion
This statement is correct. ATP is required for the inter-conversion of topoisomers. Topoisomerases use ATP hydrolysis to provide the energy necessary for the strand breakage and rejoining reactions.
Conclusion
Based on the analysis, the correct statements with respect to the inter-conversion of topoisomers of circularly closed double stranded DNA are:
- Only one strand needs to be cut
- Both strands have to be cut
- ATP is required for inter-conversion
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Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer?
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Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer?.
Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer? for IIT JAM 2024 is part of IIT JAM preparation. The Question and answers have been prepared according to the IIT JAM exam syllabus. Information about Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer? covers all topics & solutions for IIT JAM 2024 Exam. Find important definitions, questions, meanings, examples, exercises and tests below for Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer?.
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Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer?, a detailed solution for Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer? has been provided alongside types of Pick the correct statement(s) with respect to the inter-conversion of the topoisomers of a circularlyclosed double stranded DNA.a)Only one strand needs to be cutb)Both strands have to be cutc)No strand needs to be cutd)ATP is required for inter-conversionCorrect answer is option 'A,B,D'. Can you explain this answer? theory, EduRev gives you an
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