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Type II hypersensitivity
  • a)
    is antibody independent   
  • b)
    is complement independent   
  • c)
    is mediated by CD8+T cells
  • d)
    involves antibody mediated destruction of cells
Correct answer is option 'D'. Can you explain this answer?
Verified Answer
Type II hypersensitivitya)is antibody independent b)is complement inde...
Type-II hypersensitivity : In this, IgG class of antibody (Ab) is made against cell surface antigens. This Ab binds to its targets on cell surface. Now, this Ab mediates cell destruction.
The cell destruction is achieved by complement activation or antibody dependent cell mediated cytotoxicity (ADCC). Complement system kills the target cell by inserting its membrane attack complex (MAC) into cell membrane. The pores are formed, cell loses its osmotic balance and dies. MAC is made of proteins.
ADCC involves natural killer cells (NK-cells).
Examples of type-II hypersensitivity reaction are blood transfusion reaction and erythroblastosis foetalis.
So, it involves antibody mediated destruction of cells.
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Type II hypersensitivitya)is antibody independent b)is complement independent c)is mediated by CD8+T cellsd)involves antibody mediated destruction of cellsCorrect answer is option 'D'. Can you explain this answer?
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