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Only immunoglobulins to cross the placenta is
  • a)
    IgG
  • b)
    IgM
  • c)
    IgA
  • d)
    IgE
Correct answer is option 'A'. Can you explain this answer?
Verified Answer
Only immunoglobulins to cross the placenta isa)IgGb)IgMc)IgAd)IgECorre...
 Option ( b) - IgG is the right answer. 
 
( IgG ) is secreted as a monomer that is small in size  allowing it to easily perfuse tissues. It is the only antibody isotype that has receptor to facilitate passage through placenta and provide protection to the fetus in utero. 
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Most Upvoted Answer
Only immunoglobulins to cross the placenta isa)IgGb)IgMc)IgAd)IgECorre...
Immunoglobulins - IgA and IgM are excluded from crossing the placenta. Thus IgM antibodies in the newborn indicate a response to intrauterine infection. IgG is selectively transferred across the placenta.

conjugated bilirubin only crosses the placenta slowly from fetus to mother. This is in contrast to transfer of unconjugated bilirubin which is rapidly transferred from fetus to mother via active transport.

warfarin will pass from the maternal to the fetal circulation. This is in contrast to heparin, that will not cross the placenta.

maternal Grave's disease can cause transient neonatal thyrotoxicosis because thyroid stimulating immunoglobulin is of IgG class
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Only immunoglobulins to cross the placenta isa)IgGb)IgMc)IgAd)IgECorre...
Explanation:

Introduction:
Immunoglobulins (Ig) are a type of protein molecules produced by plasma cells, which are a type of white blood cells. They are also known as antibodies and play a crucial role in the immune system by recognizing and neutralizing foreign substances such as bacteria and viruses. There are five main classes of immunoglobulins: IgG, IgM, IgA, IgD, and IgE.

IgG:
IgG is the most abundant class of immunoglobulins in the blood and is responsible for providing long-term immunity against infections. It can cross the placenta and provide passive immunity to the fetus, protecting it from certain infections that the mother has been exposed to. This transfer of IgG from mother to fetus occurs mainly during the third trimester of pregnancy.

IgM:
IgM is the first antibody produced in response to an infection. It is a large molecule and does not cross the placenta easily. Therefore, its presence in the fetus is mainly due to its own production rather than maternal transfer.

IgA:
IgA is primarily found in mucosal secretions such as saliva, tears, and breast milk. It does not cross the placenta efficiently, and its transfer to the fetus is limited.

IgD:
IgD is found on the surface of B cells and is involved in the activation of the immune response. It does not cross the placenta.

IgE:
IgE is involved in allergic reactions and defense against parasites. It does not cross the placenta.

Conclusion:
In summary, only IgG immunoglobulins cross the placenta and provide passive immunity to the fetus. IgM, IgA, IgD, and IgE do not cross the placenta efficiently and are mainly produced by the fetus itself.
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Only immunoglobulins to cross the placenta isa)IgGb)IgMc)IgAd)IgECorrect answer is option 'A'. Can you explain this answer?
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