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Regarding the COVID-19 vaccination, consider the following statements:
1. The vaccine developed by AstraZeneca causes rare blood clots in certain people.
2. Heparin-induced thrombocytopenia (HIT), a condition in which heparin, which is used to dissolve clots, induces blood clots and a drop in platelet count.
Which of the statements given above is/are correct?
  • a)
    1 only
  • b)
    2 only
  • c)
    Both 1 and 2
  • d)
    Neither 1 nor 2
Correct answer is option 'C'. Can you explain this answer?
Verified Answer
Regarding the COVID-19 vaccination, consider the following statements:...
Reports of rare blood clots occurring after COVID-19 vaccination have led some countries to limit the usage of AstraZeneca’s vaccine for certain categories of people, while other countries have paused the administration.
  • An adverse effect following immunisation with the AstraZeneca jab is not merely blood clots in large vessels, but also a low platelet count.
  • The effect is similar to heparin-induced thrombocytopenia (HIT), where heparin, which is used to clear clots, actually causes blood clots and a fall in the platelet count.
  • The heparin combines with platelet factor 4 to form a complex. This immune complex induces an abnormal immune response, in which antibodies are generated against the complex.
  • This antibody-platelet factor 4-heparin immune complex binds to platelets and activates them. The platelets form clots everywhere. The low platelet count is because the platelets are used up.
  • A similar process seems to follow vaccination, except there is no heparin trigger. Scientists are still trying to establish a clinical definition for this adverse effect.
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Regarding the COVID-19 vaccination, consider the following statements:1. The vaccine developed by AstraZeneca causes rare blood clots in certain people.2. Heparin-induced thrombocytopenia (HIT), a condition in which heparin, which is used to dissolve clots, induces blood clots and a drop in platelet count.Which of the statements given above is/are correct?a)1 onlyb)2 onlyc)Both 1 and 2d)Neither 1 nor 2Correct answer is option 'C'. Can you explain this answer?
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