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what is the RDS in hydrolysis of ester
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what is the RDS in hydrolysis of ester
The rate-determining step (RDS) in the hydrolysis of esters refers to the specific step or elementary reaction that has the highest energy barrier and therefore controls the overall rate of the reaction. In ester hydrolysis, esters are broken down into their respective carboxylic acids and alcohols through the addition of water.

Here is an explanation of the RDS in the hydrolysis of esters:

1. Reaction Mechanism:
Ester hydrolysis typically occurs in the presence of an acid or base catalyst. The acid-catalyzed hydrolysis involves the protonation of the carbonyl oxygen of the ester, followed by nucleophilic attack by water and subsequent elimination of the leaving group. On the other hand, base-catalyzed hydrolysis involves the deprotonation of water by the base, which then attacks the carbonyl carbon of the ester, leading to the formation of an intermediate alkoxide ion.

2. Acid-Catalyzed Hydrolysis:
In the acid-catalyzed hydrolysis, the RDS is often the nucleophilic attack of water on the protonated carbonyl group. This step involves the breaking of the carbonyl carbon-oxygen bond and the formation of a new carbon-oxygen bond with the nucleophilic water molecule. The transition state for this step is usually the highest in energy and determines the overall rate of the reaction. After the RDS, the resulting intermediate is quickly protonated by the acid catalyst to yield the carboxylic acid and alcohol products.

3. Base-Catalyzed Hydrolysis:
In the base-catalyzed hydrolysis, the RDS is typically the nucleophilic attack of the alkoxide ion on the ester carbonyl carbon. This step involves the breaking of the carbonyl carbon-oxygen bond and the formation of a new carbon-oxygen bond with the alkoxide ion. The transition state for this step is the highest in energy and controls the reaction rate. Following the RDS, the intermediate undergoes protonation by water to produce the carboxylic acid and alcohol products.

In summary, the rate-determining step in the hydrolysis of esters can vary depending on the reaction conditions. In acid-catalyzed hydrolysis, the RDS is often the nucleophilic attack of water on the protonated carbonyl group, while in base-catalyzed hydrolysis, the RDS is typically the nucleophilic attack of the alkoxide ion on the ester carbonyl carbon. Identifying the RDS is crucial in understanding the kinetics and designing efficient strategies for ester hydrolysis reactions.
Community Answer
what is the RDS in hydrolysis of ester
At lower concentrations of base, collapse of this intermediate can become the RDS.Esters and amides are two of the least reactive carboxylic acid derivatives. ... Acid-catalysed hydrolysis reactions are reversible. The forward reaction is driven over to product by using an excess of water, usually as the solvent.
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